Publications
131 results found
Tregoning JS, Nixon P, Kuroda H, et al., 2003, Expression of tetanus toxin Fragment C in tobacco chloroplasts, NUCLEIC ACIDS RESEARCH, Vol: 31, Pages: 1174-1179, ISSN: 0305-1048
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- Citations: 172
Mathieu R, Lim J, Simpson P, et al., 2003, Resonance assignment and topology of a clostridial repetitive oligopeptide (CROP) region of toxin A from <i>Clostridium difficile</i>, JOURNAL OF BIOMOLECULAR NMR, Vol: 25, Pages: 83-84, ISSN: 0925-2738
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- Citations: 5
Calabi E, Calabi F, Phillips AD, et al., 2002, Binding of <i>Clostridium difficile</i> surface layer proteins to gastrointestinal tissues, INFECTION AND IMMUNITY, Vol: 70, Pages: 5770-5778, ISSN: 0019-9567
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- Citations: 163
Calabi E, Fairweather N, 2002, Patterns of sequence conservation in the S-layer proteins and related sequences in <i>Clostridium difficile</i>, JOURNAL OF BACTERIOLOGY, Vol: 184, Pages: 3886-3897, ISSN: 0021-9193
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- Citations: 45
Fairweather N, Sinha K, Black I, et al., 2002, Structural and functional studies of the ganglisoide binding activities of tetanus toxin, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol: 365, Pages: R19-R19, ISSN: 0028-1298
Fotinou C, Emsley P, Black I, et al., 2001, The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 32274-32281, ISSN: 0021-9258
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- Citations: 147
Calabi E, Ward S, Wren B, et al., 2001, Molecular characterization of the surface layer proteins from <i>Clostridium difficile</i>, MOLECULAR MICROBIOLOGY, Vol: 40, Pages: 1187-1199, ISSN: 0950-382X
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- Citations: 151
Stratford R, Douce G, Zhang-Barber L, et al., 2000, Influence of codon usage on the immunogenicity of a DNA vaccine against tetanus, VACCINE, Vol: 19, Pages: 810-815, ISSN: 0264-410X
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- Citations: 49
Sinha K, Box M, Lalli G, et al., 2000, Analysis of mutants of tetanus toxin H<sub>C</sub> fragment:: ganglioside binding, cell binding and retrograde axonal transport properties (vol 37, pg 1041, 2000), MOLECULAR MICROBIOLOGY, Vol: 38, Pages: 916-916, ISSN: 0950-382X
Figueiredo DM, Matthews CC, Parks DA, et al., 2000, Interaction of tetanus toxin derived hybrid proteins with neuronal cells, JOURNAL OF NATURAL TOXINS, Vol: 9, Pages: 363-379, ISSN: 1058-8108
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- Citations: 6
Schneider H, Groves M, Mühle C, et al., 2000, Retargeting of adenoviral vectors to neurons using the H<sub>c</sub> fragment of tetanus toxin, GENE THERAPY, Vol: 7, Pages: 1584-1592, ISSN: 0969-7128
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- Citations: 22
Farrar JJ, Yen LM, Cook T, et al., 2000, Tetanus, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 69, Pages: 292-301, ISSN: 0022-3050
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- Citations: 160
Sinha K, Box M, Lalli G, et al., 2000, Analysis of mutants of tetanus toxin H<sub>C</sub> fragment:: ganglioside binding, cell binding and retrograde axonal transport properties, MOLECULAR MICROBIOLOGY, Vol: 37, Pages: 1041-1051, ISSN: 0950-382X
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- Citations: 62
Matthews CC, Figueiredo DM, Wollack JB, et al., 2000, Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation -: <i>Requirement for cytosolic distribution</i>, JOURNAL OF MOLECULAR NEUROSCIENCE, Vol: 14, Pages: 155-166, ISSN: 0895-8696
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- Citations: 10
Emsley P, Fotinou C, Black I, et al., 2000, The structures of the H<sub>C</sub> fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 8889-8894, ISSN: 0021-9258
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- Citations: 124
Rice J, King CA, Spellerberg MB, et al., 1999, Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines, VACCINE, Vol: 17, Pages: 3030-3038, ISSN: 0264-410X
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- Citations: 45
Knight A, Carvajal J, Schneider H, et al., 1999, Non-viral neuronal gene delivery mediated by the H<sub>C</sub> fragment of tetanus toxin, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 259, Pages: 762-769, ISSN: 0014-2956
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- Citations: 50
Watts C, Antoniou A, Manoury B, et al., 1998, Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen, IMMUNOLOGICAL REVIEWS, Vol: 164, Pages: 11-16, ISSN: 0105-2896
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- Citations: 42
Anderson R, Gao XM, Papakonstantinopoulou A, et al., 1997, Immunization of mice with DNA encoding fragment C of tetanus toxin, VACCINE, Vol: 15, Pages: 827-829, ISSN: 0264-410X
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- Citations: 19
Figueiredo DM, Hallewell RA, Chen LL, et al., 1997, Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport, EXPERIMENTAL NEUROLOGY, Vol: 145, Pages: 546-554, ISSN: 0014-4886
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- Citations: 64
Emsley P, Charles IG, Fairweather NF, et al., 1996, Structure of Bordetella pertussis virulence factor P.69 pertactin, NATURE, Vol: 381, Pages: 90-92, ISSN: 0028-0836
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- Citations: 260
Harwood G, Lockyer M, Giles H, et al., 1995, Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors, FEBS LETTERS, Vol: 377, Pages: 73-76, ISSN: 0014-5793
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- Citations: 28
FIGUEIREDO D, TURCOTTE C, FRANKEL G, et al., 1995, CHARACTERIZATION OF RECOMBINANT TETANUS TOXIN DERIVATIVES SUITABLE FOR VACCINE DEVELOPMENT, INFECTION AND IMMUNITY, Vol: 63, Pages: 3218-3221, ISSN: 0019-9567
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- Citations: 35
SIMITSEK PD, CAMPBELL DG, LANZAVECCHIA A, et al., 1995, MODULATION OF ANTIGEN-PROCESSING BY BOUND ANTIBODIES CAN BOOST OR SUPPRESS CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX PRESENTATION OF DIFFERENT T-CELL DETERMINANTS, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 181, Pages: 1957-1963, ISSN: 0022-1007
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- Citations: 241
CHARLES I, FAIRWEATHER N, PICKARD D, et al., 1994, EXPRESSION OF THE BORDETELLA-PERTUSSIS P.69 PERTACTIN ADHESIN IN ESCHERICHIA-COLI - FATE OF THE CARBOXY-TERMINAL DOMAIN, MICROBIOLOGY-SGM, Vol: 140, Pages: 3301-3308, ISSN: 1350-0872
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- Citations: 37
Charles I, Fairweather N, Pickard D, et al., 1994, Expression of the Bordetella pertussis P.69 pertactin adhesin in Escherichia coli: fate of the carboxy-terminal domain., Microbiology (Reading), Vol: 140 ( Pt 12), Pages: 3301-3308, ISSN: 1350-0872
The mature pertactin protein (P.69) of Bordetella pertussis can be isolated from the bacterial cell surface as a polypeptide with an apparent molecular mass of 69,000 Da as determined by sodium dodecyl sulphate gel electrophoresis. However the open reading frame of prn, the pertactin gene, encodes a polypeptide with a predicted molecular mass of 93,478 Da, referred to as P.93. Expression of the prn gene in Escherichia coli leads to the synthesis of the full-length P.93 polypeptide, which is rapidly processed to the mature P.69 protein located at the cell surface. The P.93 precursor polypeptide is processed at both termini. A 34 amino acid long signal sequence is removed from the amino-terminus and a polypeptide sequence of about 30,000 Da (P.30) is cleaved from the carboxy-terminus. Deletion of the 3' region of prn, encoding P.30, results in the expression of an intracellular form of P.69. Antiserum which recognizes P.30 was raised using synthetic peptides based on the primary amino acid sequence of the region. This anti-P.30 serum was used in a Western blot analysis of fractionated cells of B. pertussis and E. coli harbouring the intact prn gene. The P.30 polypeptide was readily detected in outer membrane fractions prepared from both of these bacterial species, although it could not be shown to be exposed at the cell surface.
KHAN CMA, VILLARREALRAMOS B, PIERCE RJ, et al., 1994, CONSTRUCTION, EXPRESSION, AND IMMUNOGENICITY OF THE SCHISTOSOMA-MANSONI P-28 GLUTATHIONE-S-TRANSFERASE AS A GENETIC FUSION TO TETANUS TOXIN FRAGMENT-C IN A LIVE ARO ATTENUATED VACCINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 91, Pages: 11261-11265, ISSN: 0027-8424
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- Citations: 68
LI Y, FORAN P, FAIRWEATHER NF, et al., 1994, A SINGLE MUTATION IN THE RECOMBINANT LIGHT-CHAIN OF TETANUS TOXIN ABOLISHES ITS PROTEOLYTIC ACTIVITY AND REMOVES THE TOXICITY SEEN AFTER RECONSTITUTION WITH NATIVE HEAVY-CHAIN, BIOCHEMISTRY, Vol: 33, Pages: 7014-7020, ISSN: 0006-2960
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- Citations: 56
BARBEY C, TIERCY JM, FAIRWEATHER N, et al., 1994, PROCESSING AND PRESENTATION OF TETANUS TOXIN BY ANTIGEN-PRESENTING CELLS FROM PATIENTS WITH CHRONIC GRANULOMATOUS-DISEASE (CGD) TO HUMAN SPECIFIC T-CELL CLONES ARE NOT IMPAIRED, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 95, Pages: 227-231, ISSN: 0009-9104
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- Citations: 6
EMSLEY P, MCDERMOTT G, CHARLES IG, et al., 1994, CRYSTALLOGRAPHIC CHARACTERIZATION OF PERTACTIN, A MEMBRANE-ASSOCIATED PROTEIN FROM BORDETELLA-PERTUSSIS, JOURNAL OF MOLECULAR BIOLOGY, Vol: 235, Pages: 772-773, ISSN: 0022-2836
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- Citations: 14
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