Imperial College London
Portrait Picture

Professor Neil Fairweather

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 5247n.fairweather

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fairweather:2015:10.1074/jbc.M115.665091,
author = {Fairweather, NF and Peltier, J and Shaw, HA and Couchman, E and Dawson, LF and Choudhary, JS and LU, Y and Kaever, V and Wren, BW},
doi = {10.1074/jbc.M115.665091},
journal = {Journal of Biological Chemistry},
pages = {24453--24469},
title = {Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage},
url = {http://dx.doi.org/10.1074/jbc.M115.665091},
volume = {290},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Bacteria use variousmechanisms to anchor their surface proteins,including a sortase enzyme.Results: Covalent anchoring of proteins to thepeptidoglycan in Clostridium difficile and itsregulation by cyclic-di-GMP and proteaseactivity are demonstrated.Conclusion: A novel regulatory mechanism ofcell wall protein anchoring is found.Significance: Elucidating how proteins areanchored may shed light on control of bacterialcolonization in vivo.
AU  - Fairweather,NF
AU  - Peltier,J
AU  - Shaw,HA
AU  - Couchman,E
AU  - Dawson,LF
AU  - Choudhary,JS
AU  - LU,Y
AU  - Kaever,V
AU  - Wren,BW
DO  - 10.1074/jbc.M115.665091
EP  - 24469
PY  - 2015///
SN  - 1083-351X
SP  - 24453
TI  - Cyclic diGMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage
T2  - Journal of Biological Chemistry
UR  - http://dx.doi.org/10.1074/jbc.M115.665091
UR  - http://hdl.handle.net/10044/1/27191
VL  - 290
ER  -
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