Imperial College London
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Professor Nuno R. Faria

Faculty of Medicine, School of Public Health

Professor in Virus Genomic Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3560n.faria

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Gutierrez:2021:10.1101/2021.03.31.21254685,
author = {Gutierrez, B and Márquez, S and Prado-Vivar, B and Becerra-Wong, M and Guadalupe, JJ and da, Silva Candido D and Fernandez-Cadena, JC and Morey-Leon, G and Armas-Gonzalez, R and Andrade-Molina, DM and Bruno, A and de, Mora D and Olmedo, M and Portugal, D and Gonzalez, M and Orlando, A and Drexler, JF and Moreira-Soto, A and Sander, A-L and Brünink, S and Kühne, A and Patiño, L and Carrazco-Montalvo, A and Mestanza, O and Zurita, J and Sevillano, G and du, Plessis L and McCrone, JT and Coloma, J and Trueba, G and Barragán, V and Rojas-Silva, P and Grunauer, M and Kraemer, MUG and Faria, NR and Escalera-Zamudio, M and Pybus, OG and Cárdenas, P},
doi = {10.1101/2021.03.31.21254685},
title = {Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador.},
url = {http://dx.doi.org/10.1101/2021.03.31.21254685},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Characterisation of SARS-CoV-2 genetic diversity through space and time can reveal trends in virus importation and domestic circulation, and permit the exploration of questions regarding the early transmission dynamics. Here we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the COVID-19 pandemic. We generate and analyse 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylgeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions (NPIs), with differential degrees of persistence and national dissemination.
AU  - Gutierrez,B
AU  - Márquez,S
AU  - Prado-Vivar,B
AU  - Becerra-Wong,M
AU  - Guadalupe,JJ
AU  - da,Silva Candido D
AU  - Fernandez-Cadena,JC
AU  - Morey-Leon,G
AU  - Armas-Gonzalez,R
AU  - Andrade-Molina,DM
AU  - Bruno,A
AU  - de,Mora D
AU  - Olmedo,M
AU  - Portugal,D
AU  - Gonzalez,M
AU  - Orlando,A
AU  - Drexler,JF
AU  - Moreira-Soto,A
AU  - Sander,A-L
AU  - Brünink,S
AU  - Kühne,A
AU  - Patiño,L
AU  - Carrazco-Montalvo,A
AU  - Mestanza,O
AU  - Zurita,J
AU  - Sevillano,G
AU  - du,Plessis L
AU  - McCrone,JT
AU  - Coloma,J
AU  - Trueba,G
AU  - Barragán,V
AU  - Rojas-Silva,P
AU  - Grunauer,M
AU  - Kraemer,MUG
AU  - Faria,NR
AU  - Escalera-Zamudio,M
AU  - Pybus,OG
AU  - Cárdenas,P
DO  - 10.1101/2021.03.31.21254685
PY  - 2021///
TI  - Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador.
UR  - http://dx.doi.org/10.1101/2021.03.31.21254685
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33851177
ER  -
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