Summary
Dr Niklas Feldhahn received his PhD in 2006 at the University of Düsseldorf in Germany under the supervision of Professor Markus Müschen. His research during his PhD focused on oncogenic signaling in B-lymphoid leukaemia. After his PhD, Dr Feldhahn joined the laboratory of Professor Nora Heisterkamp at the Children's Hospital Los Angeles, to study mechanisms of drug-resistance to small-molecule inhibitors. In 2008, he joined the laboratory of Professor Michel Nussenzweig at the Rockefeller University New York as a senior postdoctoral research fellow, where he generated in vivo models for DNA damage response genes and analyzed DNA damage and genomic instability in normal and malignant B-cells using next-generation sequencing-based methods.
Niklas Feldhahn joined the Centre for Haematology of the Department of Medicine at Imperial College London in 2013 as an early career researcher and Bennett Fellow of Blood Cancer UK (www.bloodcancer.org.uk) and became a Lecturer in the Department of Immunology & Inflammation in 2019.
The laboratory of the Feldhahn group investigates oncogene function in B-lymphoid and myeloid leukemia such as BCR::ABL1 in Ph B-lineage acute lymphoblastic leukaemia (B-ALL) and chronic myeloid leukaemia (CML), and EVI1 in CML and acute myeloid leukaemia (AML). Another main focus is the analysis of transcriptional deregulation promoting leukaemia,
The research of the Feldhahn lab is supported by Blood Cancer UK (www.bloodcancer.org.uk), the Kay Kendall Leukaemia Fund (KKLF, www.kklf.org.uk), The Blood Fund/Imperial Health Charit (www.imperialcharity.org.uk/), Leuka/Leukemia UK (www.leukaemiauk.org.uk), the European commission (EC) and Action against cancer (AAC, https://www.aacancer.org).
Current lab: Dr Han Leng Ng (PDRA), Jintao Zhu (PhD student), Trudy Glaser (PhD student)
Previous people: Bryant Boulianne (PDRA, 2013-2017), Kevin Blighe (Bioinformatician, 2015), Mark C. Robinson (Bioinformatician, 2016-2018), Matthias Pfeifer (PDRA, 2016-2018), Reto Brem (PDRA, 2017-2019), Anju Kanda (Research Technician, 2016-2017), Timothy P. Lippert (PhD student, 2017-2020), Philippa May (PhD student and PDRA, 2016-2012)
Publications
Journals
Ng HL, Robinson ME, May PC, et al., 2024, Promoter-centred chromatin interactions associated with EVI1 expression in EVI1+3q- myeloid leukaemia cells., Br J Haematol, Vol:204, Pages:945-958
Lippert T, Marzec P, Idilli A, et al., 2021, Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres, Nature Communications, Vol:12, ISSN:2041-1723
Pfeifer M, Brem R, Lippert T, et al., 2019, SSB1/SSB2 proteins safeguard B-cell development by protecting the genomes of B-cell precursors, Journal of Immunology, Vol:202, ISSN:1550-6606, Pages:3423-3433
Parzych K, Saavedra Garcia P, Valbuena G, et al., 2019, The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation, Oncogene, Vol:38, ISSN:0950-9232, Pages:3216-3231
Conference
Katsarou A, Trasanidis N, Alvarez-Benayas J, et al., 2019, Oncogenic MAF in Co-Operation with IRF4 Confers Extensive Chromatin Re-Arrangement in Plasma Cells and Generates 'Neo-Enhancers' That Regulate Genes Critical for Myeloma Biology, 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), AMER SOC HEMATOLOGY, ISSN:0006-4971