Imperial College London
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DrNiklasFeldhahn

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Molecular Haematology
 
 
 
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Contact

 

+44 (0)20 3313 1528n.feldhahn Website

 
 
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Location

 

, 4N3DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jankovic:2013:10.1016/j.molcel.2012.11.029,
author = {Jankovic, M and Feldhahn, N and Oliveira, TY and Silva, IT and Kieffer-Kwon, KR and Yamane, A and Resch, W and Klein, I and Robbiani, DF and Casellas, R and Nussenzweig, MC},
doi = {10.1016/j.molcel.2012.11.029},
journal = {Mol Cell},
pages = {623--631},
title = {53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma},
url = {http://dx.doi.org/10.1016/j.molcel.2012.11.029},
volume = {49},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Deficiencies in factors that regulate the DNA damage response enhance the incidence of malignancy by destabilizing the genome. However, the precise influence of the DNA damage response on regulation of cancer-associated rearrangements is not well defined. Here we examine the genome-wide impact of tumor protein P53-binding protein 1 (53BP1) deficiency in lymphoma and translocation. While both activation-induced cytidine deaminase (AID) and 53BP1 have been associated with cancer in humans, neither AID overexpression nor loss of 53BP1 is sufficient to produce malignancy. However, the combination of 53BP1 deficiency and AID deregulation results in B cell lymphoma. Deep sequencing of the genome of 53BP1(-/-) cancer cells and translocation capture sequencing (TC-Seq) of primary 53BP1(-/-) B cells revealed that their chromosomal rearrangements differ from those found in wild-type cells in that they show increased DNA end resection. Moreover, loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.
AU  - Jankovic,M
AU  - Feldhahn,N
AU  - Oliveira,TY
AU  - Silva,IT
AU  - Kieffer-Kwon,KR
AU  - Yamane,A
AU  - Resch,W
AU  - Klein,I
AU  - Robbiani,DF
AU  - Casellas,R
AU  - Nussenzweig,MC
DO  - 10.1016/j.molcel.2012.11.029
EP  - 631
PY  - 2013///
SN  - 1097-4164
SP  - 623
TI  - 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma
T2  - Mol Cell
UR  - http://dx.doi.org/10.1016/j.molcel.2012.11.029
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23290917
VL  - 49
ER  -
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