Imperial College London
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DrNiklasFeldhahn

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Molecular Haematology
 
 
 
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Contact

 

+44 (0)20 3313 1528n.feldhahn Website

 
 
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Location

 

, 4N3DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Robbiani:2009:10.1016/j.molcel.2009.11.007,
author = {Robbiani, DF and Bunting, S and Feldhahn, N and Bothmer, A and Camps, J and Deroubaix, S and McBride, KM and Klein, IA and Stone, G and Eisenreich, TR and Ried, T and Nussenzweig, A and Nussenzweig, MC},
doi = {10.1016/j.molcel.2009.11.007},
journal = {Mol Cell},
pages = {631--641},
title = {AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations},
url = {http://dx.doi.org/10.1016/j.molcel.2009.11.007},
volume = {36},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however, the extent of "off-target" DSB formation and its role in translocation-associated malignancy is unknown. Here, we show that deregulated expression of AID causes widespread genome instability, which alone is insufficient to induce B cell lymphoma; transformation requires concomitant loss of the tumor suppressor p53. Mature B cell lymphomas arising as a result of deregulated AID expression are phenotypically diverse and harbor clonal reciprocal translocations involving a group of Immunoglobulin (Ig) and non-Ig genes that are direct targets of AID. This group includes miR-142, a previously unknown micro-RNA target that is translocated in human B cell malignancy. We conclude that AID produces DSBs throughout the genome, which can lead to lymphoma-associated chromosome translocations in mature B cells.
AU  - Robbiani,DF
AU  - Bunting,S
AU  - Feldhahn,N
AU  - Bothmer,A
AU  - Camps,J
AU  - Deroubaix,S
AU  - McBride,KM
AU  - Klein,IA
AU  - Stone,G
AU  - Eisenreich,TR
AU  - Ried,T
AU  - Nussenzweig,A
AU  - Nussenzweig,MC
DO  - 10.1016/j.molcel.2009.11.007
EP  - 641
PY  - 2009///
SN  - 1097-4164
SP  - 631
TI  - AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations
T2  - Mol Cell
UR  - http://dx.doi.org/10.1016/j.molcel.2009.11.007
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19941823
VL  - 36
ER  -
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