Imperial College London
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DrNiklasFeldhahn

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Molecular Haematology
 
 
 
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Contact

 

+44 (0)20 3313 1528n.feldhahn Website

 
 
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Location

 

, 4N3DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Klemm:2009:10.1016/j.ccr.2009.07.030,
author = {Klemm, L and Duy, C and Iacobucci, I and Kuchen, S and von, Levetzow G and Feldhahn, N and Henke, N and Li, Z and Hoffmann, TK and Kim, YM and Hofmann, WK and Jumaa, H and Groffen, J and Heisterkamp, N and Martinelli, G and Lieber, MR and Casellas, R and Muschen, M},
doi = {10.1016/j.ccr.2009.07.030},
journal = {Cancer Cell},
pages = {232--245},
title = {The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia},
url = {http://dx.doi.org/10.1016/j.ccr.2009.07.030},
volume = {16},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 mutations and progress into fatal B lymphoid blast crisis (LBC). Despite its clinical significance, the mechanism of progression into LBC is unknown. Here, we show that LBC but not CML cells express the B cell-specific mutator enzyme AID. We demonstrate that AID expression in CML cells promotes overall genetic instability by hypermutation of tumor suppressor and DNA repair genes. Importantly, our data uncover a causative role of AID activity in the acquisition of BCR-ABL1 mutations leading to Imatinib resistance, thus providing a rationale for the rapid development of drug resistance and blast crisis progression.
AU  - Klemm,L
AU  - Duy,C
AU  - Iacobucci,I
AU  - Kuchen,S
AU  - von,Levetzow G
AU  - Feldhahn,N
AU  - Henke,N
AU  - Li,Z
AU  - Hoffmann,TK
AU  - Kim,YM
AU  - Hofmann,WK
AU  - Jumaa,H
AU  - Groffen,J
AU  - Heisterkamp,N
AU  - Martinelli,G
AU  - Lieber,MR
AU  - Casellas,R
AU  - Muschen,M
DO  - 10.1016/j.ccr.2009.07.030
EP  - 245
PY  - 2009///
SN  - 1878-3686
SP  - 232
TI  - The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia
T2  - Cancer Cell
UR  - http://dx.doi.org/10.1016/j.ccr.2009.07.030
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19732723
VL  - 16
ER  -
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