Imperial College London
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DrNiklasFeldhahn

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Molecular Haematology
 
 
 
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Contact

 

+44 (0)20 3313 1528n.feldhahn Website

 
 
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Location

 

, 4N3DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Robbiani:2015:10.1016/j.cell.2015.07.019,
author = {Robbiani, DF and Deroubaix, S and Feldhahn, N and Oliveira, TY and Callen, E and Wang, Q and Jankovic, M and Silva, IT and Rommel, PC and Bosque, D and Eisenreich, T and Nussenzweig, A and Nussenzweig, MC},
doi = {10.1016/j.cell.2015.07.019},
journal = {Cell},
pages = {727--737},
title = {Plasmodium infection promotes genomic instability and AID-dependent B cell lymphoma},
url = {http://dx.doi.org/10.1016/j.cell.2015.07.019},
volume = {162},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic infection with Plasmodium falciparum was epidemiologically associated with endemic Burkitt’s lymphoma, a mature B cell cancer characterized by chromosome translocation between the c-myc oncogene and Igh, over 50 years ago. Whether infection promotes B cell lymphoma, and if so by which mechanism, remains unknown. To investigate the relationship between parasitic disease and lymphomagenesis, we used Plasmodium chabaudi (Pc) to produce chronic malaria infection in mice. Pc induces prolonged expansion of germinal centers (GCs), unique compartments in which B cells undergo rapid clonal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator. GC B cells elicited during Pc infection suffer widespread DNA damage, leading to chromosome translocations. Although infection does not change the overall rate, it modifies lymphomagenesis to favor mature B cell lymphomas that are AID dependent and show chromosome translocations. Thus, malaria infection favors mature B cell cancers by eliciting protracted AID expression in GC B cells.
AU  - Robbiani,DF
AU  - Deroubaix,S
AU  - Feldhahn,N
AU  - Oliveira,TY
AU  - Callen,E
AU  - Wang,Q
AU  - Jankovic,M
AU  - Silva,IT
AU  - Rommel,PC
AU  - Bosque,D
AU  - Eisenreich,T
AU  - Nussenzweig,A
AU  - Nussenzweig,MC
DO  - 10.1016/j.cell.2015.07.019
EP  - 737
PY  - 2015///
SN  - 0092-8674
SP  - 727
TI  - Plasmodium infection promotes genomic instability and AID-dependent B cell lymphoma
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2015.07.019
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359741400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S009286741500896X?via%3Dihub
VL  - 162
ER  -
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