My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep.
My laboratory is merged with that of Bill Wisden and our joint website can be found here: franks-wisden-lab.
Current Group members
PREVIOUS GROUP MEMBERS
et al., 2023, Somatostatin neurons in prefrontal cortex initiate sleep preparatory behavior and sleep via the preoptic and lateral hypothalamus, Nature Neuroscience, Vol:26, ISSN:1097-6256, Pages:1805-1819
Wisden W, Franks NP, 2023, Biochemical pathways of sleep, Cell Research, Vol:33, ISSN:1001-0602, Pages:417-418
Nollet M, Franks NP, Wisden W, 2023, Understanding sleep regulation in normal and pathological conditions, and why it matters, Journal of Huntington's Disease, Vol:12, ISSN:1879-6400, Pages:105-119
et al., 2022, A specific circuit in the midbrain detects stress and induces restorative sleep, Science, Vol:377, ISSN:1095-9203, Pages:1-10
et al., 2022, NEURONS IN PREFRONTAL CORTEX RESPOND TO SLEEP DEPRIVATION BY INITIATING SLEEP PREPARATORY BEHAVIOUR AND NREM SLEEP, ELSEVIER, Pages:S20-S20, ISSN:1389-9457