Imperial College London
Alternate

Professor Nick Franks, FRS

Faculty of Natural Sciences, Department of Life Sciences

Professor of Biophysics and Anaesthetics
 
 
 
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Contact

 

+44 (0)20 7594 7624n.franks Website

 
 
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Location

 

401ASir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

217 results found

Franks NP, Renavides R, Maze M, 2006, Air bubble growth in water - Reply, ANESTHESIOLOGY, Vol: 105, Pages: 1059-1060, ISSN: 0003-3022

Journal article

Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze Met al., 2006, Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass - Phase I study, ANESTHESIOLOGY, Vol: 104, Pages: 458-465, ISSN: 0003-3022

Journal article

Ma DQ, Hossain M, Pettet GKJ, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze Met al., 2006, Xenon preconditioning reduces brain damage from neonatal asphyxia in rats, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 26, Pages: 199-208, ISSN: 0271-678X

Journal article

Benavides R, Maze M, Franks NP, 2006, Expansion of gas bubbles by nitrous oxide and xenon, ANESTHESIOLOGY, Vol: 104, Pages: 299-302, ISSN: 0003-3022

Journal article

Nelson LE, Franks NP, Maze M, 2006, The mechanistic relationship between NREM sleep and anesthesia, Sleep and Sleep Disorders: A Neuropsychopharmacological Approach, Pages: 43-52, ISBN: 9780387276816

The mechanisms by which both natural sleep and anesthesia generate and maintain a loss of consciousness are currently the focus of much investigation. The neuronal networks of substrates mediating endogenous regulation of consciousness level are complex. Much research has focused on understanding the neural correlates of wakefulness, NREM sleep, REM sleep and transitions between sleep and wake states, but a molecular basis for these behavioral alterations is only beginning to emerge. Mechanisms governing anesthesia, the pharmacological modulation of consciousness level, which shares the key common feature of loss of response to external stimuli with endogenous sleep, are even less clear. Several qualitative similarities between sleep and anesthesia suggest that pharmacological "sleep" may be transduced via activation of existing neurological pathways involved in promoting natural sleep. This chapter reviews how these mechanisms may intersect and outlines the neurochemical, pharmacological, and anatomical evidence that two classes of anesthetic drugs exert their hypnotic effects, at least in part, by duplicating activities of specific brain regions important for initiating and maintaining endogenous NREM sleep. Experiments demonstrate that anesthetic agents that are proven, or postulated, to act on α2-adrenoceptors (e.g., dexmedetomidine, clonidine) and GABAA receptors (e.g., muscimol, propofol, and pentobarbital, isoflurane) induce a loss of consciousness, at least in part, via activation of endogenous nonrapid eye movement (NREM) sleep-promoting pathways at different junctions. One critical difference relates to the fact that the noradrenergic neurons within the locus coeruleus maintain their "awake" activity during hypnosis produced by compounds putatively mediated via the GABAA receptor while this collection of neurons is inactive during hypnosis produced by α2-adrenoceptor agonists. This crucial difference may represent the reason

Book chapter

Franks NP, 2006, Molecular targets underlying general anaesthesia, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 147, Pages: S72-S81, ISSN: 0007-1188

Journal article

Peterson BK, Valenzuela CA, Martin JCS, Franks NPet al., 2005, Adsorption simulations and biology: Grand canonical Monte Carlo calculations of binding locations, occupancy, and free energies of xenon in comp and mutant phage T4 lysozyme L99a

The binding of xenon with the oligomerization domain of rat cartilage oligomeric matrix protein and with an engineered mutant of phage T4 lysozyme has been studied by Grand Canonical Monte Carlo simulations. In both proteins, the xenon sites determined by previous X-ray diffraction studies were found via analysis of the simulation results. A novel clustering algorithm facilitated the rapid identification of binding sites and enabled the calculation of site occupancies, binding equilibrium constants, and binding free energies from the simulation data.

Conference paper

Lockwood G, Downie N, Taylor K, Franks NP, Maze Met al., 2005, Utility of xenon in patients undergoing coronary revascularization (CABG), Annual Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 573P-574P, ISSN: 0007-0912

Conference paper

Ma DQ, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze Met al., 2005, Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia, ANNALS OF NEUROLOGY, Vol: 58, Pages: 182-193, ISSN: 0364-5134

Journal article

White IL, Franks NP, Dickinson R, 2005, Effects of isoflurane and xenon on Ba<SUP>2+</SUP>-currents mediated by N-type calcium channels, BRITISH JOURNAL OF ANAESTHESIA, Vol: 94, Pages: 784-790, ISSN: 0007-0912

Journal article

Caley AJ, Gruss M, Franks NP, 2005, The effects of hypoxia on the modulation of human TREK-1 potassium channels, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 562, Pages: 205-212, ISSN: 0022-3751

Journal article

Franks NP, Honoré E, 2004, The TREK K<sub>2P</sub> channels and their role in general anaesthesia and neuroprotection, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 25, Pages: 601-608, ISSN: 0165-6147

Journal article

Ma DQ, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze Met al., 2004, Dexmedetomidine produces its neuroprotective effect via the α<sub>2A</sub>-adrenoceptor subtype, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 502, Pages: 87-97, ISSN: 0014-2999

Journal article

Gruss M, Mathie A, Lieb WR, Franks NPet al., 2004, The two-pore-domain K<SUP>+</SUP> channels TREK-1 and TASK-3 are differentially modulated by copper and zinc, MOLECULAR PHARMACOLOGY, Vol: 66, Pages: 530-537, ISSN: 0026-895X

Journal article

Franks NP, 2004, David Mervyn Blow (1931-2004): Pioneer of protein crystallography, STRUCTURE, Vol: 12, Pages: 1353-1354, ISSN: 0969-2126

Journal article

Franks NP, Lieb WR, 2004, Seeing the light - Protein theories of general anesthesia, ANESTHESIOLOGY, Vol: 101, Pages: 235-237, ISSN: 0003-3022

Journal article

Abraini JH, David HN, Nicole O, MacKenzie ET, Buisson Aet al., 2004, Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration, ANESTHESIOLOGY, Vol: 101, Pages: 260-261, ISSN: 0003-3022

Journal article

Homi HM, Yokoo N, Ma DQ, Warner DS, Franks NP, Maze M, Grocott HPet al., 2004, Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration - In reply, ANESTHESIOLOGY, Vol: 101, Pages: 261-261, ISSN: 0003-3022

Journal article

Nelson LE, Franks NP, Maze M, 2004, Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia, ANESTHESIOLOGY, Vol: 100, Pages: 1341-1342, ISSN: 0003-3022

Journal article

Ma DQ, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze Met al., 2004, Xenon exerts age-independent antinociception in Fischer rats, ANESTHESIOLOGY, Vol: 100, Pages: 1313-1318, ISSN: 0003-3022

Journal article

Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NPet al., 2004, Two-pore-domain K<SUP>+</SUP> channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane, MOLECULAR PHARMACOLOGY, Vol: 65, Pages: 443-452, ISSN: 0026-895X

Journal article

Plested AJR, Wildman SS, Lieb WR, Franks NPet al., 2004, Determinants of the sensitivity of AMPA receptors to xenon, ANESTHESIOLOGY, Vol: 100, Pages: 347-358, ISSN: 0003-3022

Journal article

Sanders RD, Franks NP, Maze M, 2003, Xenon: no stranger to anaesthesia, BRITISH JOURNAL OF ANAESTHESIA, Vol: 91, Pages: 709-717, ISSN: 0007-0912

Journal article

Homi HM, Yokoo N, Ma DQ, Warner DS, Franks NP, Maze M, Grocott HPet al., 2003, The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice, ANESTHESIOLOGY, Vol: 99, Pages: 876-881, ISSN: 0003-3022

Journal article

Ma DQ, Hossain M, Rajakumaraswamy N, Franks NP, Maze Met al., 2003, Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model, ANESTHESIOLOGY, Vol: 99, Pages: 748-751, ISSN: 0003-3022

Journal article

Dickinson R, Awaiz S, Whittington MA, Lieb WR, Franks NPet al., 2003, The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro, NEUROPHARMACOLOGY, Vol: 44, Pages: 864-872, ISSN: 0028-3908

Journal article

Ma DQ, Yang H, Lynch J, Franks NP, Maze M, Grocott HPet al., 2003, Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat, ANESTHESIOLOGY, Vol: 98, Pages: 690-698, ISSN: 0003-3022

Journal article

Nelson LE, Lu J, Guo TZ, Saper CB, Franks NP, Maze Met al., 2003, The α<sub>2</sub>-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects, ANESTHESIOLOGY, Vol: 98, Pages: 428-436, ISSN: 0003-3022

Journal article

Franks NP, Maze M, 2002, Molecular and cellular actions of xenon - Evidence from in vitro studies, ISSN: 0941-4223

Conference paper

Maze M, Franks N, 2002, Neuroprotective and neurotoxic effects of xenon in vivo, ISSN: 0941-4223

Conference paper

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