Publications
216 results found
FRANKS NP, LIEB WR, 1991, SELECTIVE EFFECTS OF VOLATILE GENERAL-ANESTHETICS ON IDENTIFIED NEURONS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol: 625, Pages: 54-70, ISSN: 0077-8923
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- Citations: 28
MOSS GWJ, FRANKS NP, LIEB WR, 1991, MODULATION OF THE GENERAL ANESTHETIC SENSITIVITY OF A PROTEIN - A TRANSITION BETWEEN 2 FORMS OF FIREFLY LUCIFERASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 88, Pages: 134-138, ISSN: 0027-8424
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- Citations: 63
CURRY S, MOSS GWJ, DICKINSON R, et al., 1991, PROBING THE MOLECULAR DIMENSIONS OF GENERAL ANESTHETIC TARGET SITES IN TADPOLES (XENOPUS-LAEVIS) AND MODEL SYSTEMS USING CYCLOALCOHOLS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 102, Pages: 167-173, ISSN: 0007-1188
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- Citations: 28
FRANKS NP, LIEB WR, 1991, AN ANESTHETIC-ACTIVATED POTASSIUM CHANNEL, 5TH CONGRESS OF THE INTERNATIONAL SOC FOR BIOMEDICAL RESEARCH ON ALCOHOLISM / 1990 ANNUAL MEETING OF THE RESEARCH ON ALCOHOLISM, Publisher: OXFORD UNIV PRESS UNITED KINGDOM, Pages: 197-202, ISSN: 0735-0414
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- Citations: 5
FRANKS NP, LIEB WR, 1991, SELECTIVE EFFECTS OF VOLATILE GENERAL-ANESTHETICS ON IDENTIFIED NEURONS, CONF ON MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS, Publisher: NEW YORK ACAD SCIENCES, Pages: 54-70
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- Citations: 28
Franks NP, Lieb WR, 1991, An anaesthetic-activated potassium channel., Alcohol Alcohol Suppl, Vol: 1, Pages: 197-202, ISSN: 1358-6173
We have discovered a novel potassium current in an identified molluscan neuron which is activated at surgical levels of volatile general anaesthetics. The current is not significantly voltage-gated and persists for as long as the anaesthetic is present. The anaesthetic response is completely reversibly and saturates at low anaesthetic partial pressures. The current is absent in surrounding neurons.
FRANKS NP, LIEB WR, 1990, MECHANISMS OF GENERAL-ANESTHESIA, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 87, Pages: 199-205, ISSN: 0091-6765
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- Citations: 113
CURRY S, LIEB WR, FRANKS NP, 1990, EFFECTS OF GENERAL-ANESTHETICS ON THE BACTERIAL LUCIFERASE ENZYME FROM VIBRIO-HARVEYI - AN ANESTHETIC TARGET SITE WITH DIFFERENTIAL SENSITIVITY, BIOCHEMISTRY, Vol: 29, Pages: 4641-4652, ISSN: 0006-2960
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- Citations: 48
FRANKS NP, LIEB WR, 1988, VOLATILE GENERAL-ANESTHETICS ACTIVATE A NOVEL NEURONAL K+ CURRENT, NATURE, Vol: 333, Pages: 662-664, ISSN: 0028-0836
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- Citations: 182
FRANKS NP, LIEB WR, 1987, ANESTHETICS ON THE MIND, NATURE, Vol: 328, Pages: 113-114, ISSN: 0028-0836
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- Citations: 37
Franks NP, Lieb WR, 1987, Neuron membranes: anaesthetics on the mind., Nature, Vol: 328, Pages: 113-114, ISSN: 0028-0836
FRANKS NP, LIEB WR, 1987, WHAT IS THE MOLECULAR NATURE OF GENERAL ANESTHETIC TARGET SITES, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 8, Pages: 169-174, ISSN: 0165-6147
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- Citations: 167
Franks NP, Lieb WR, 1987, Are the biological effects of ethanol due to primary interactions with lipids or with proteins?, Alcohol Alcohol Suppl, Vol: 1, Pages: 139-145, ISSN: 1358-6173
The biological effects of ethanol and other simple organic molecules have traditionally been ascribed to their actions on the lipid portions of biological membranes. However, at the concentrations at which these molecules exert their pharmacological effects in man and other animals, changes in the structure and fluidity of lipid bilayers are extremely small and can be mimicked by a change in temperature of only about 1 degree C. On the other hand, we have found that the activity of a soluble protein can be markedly affected at these concentrations. Indeed, the concentrations of general anaesthetics which half-inhibit the activity of this enzyme are essentially identical to those which cause general anaesthesia in animals. The evidence thus suggests that ethanol and other simple molecules act directly on proteins rather than lipids.
Franks NP, Lieb WR, 1986, Mapping of general anaesthetic target sites (reply), Nature, Vol: 319, ISSN: 0028-0836
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- Citations: 3
FRANKS NP, LIEB WR, 1986, PARTITIONING OF LONG-CHAIN ALCOHOLS INTO LIPID BILAYERS - IMPLICATIONS FOR MECHANISMS OF GENERAL-ANESTHESIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 83, Pages: 5116-5120, ISSN: 0027-8424
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- Citations: 161
ELLIOTT JR, HAYDON DA, 1986, MAPPING OF GENERAL ANESTHETIC TARGET SITES, NATURE, Vol: 319, Pages: 77-78, ISSN: 0028-0836
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- Citations: 14
FRANKS NP, LIEB WR, 1986, THE PHARMACOLOGY OF SIMPLE MOLECULES, ARCHIVES OF TOXICOLOGY, Pages: 27-37, ISSN: 0340-5761
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- Citations: 13
Franks NP, Lieb WR, 1986, The pharmacology of simple molecules., Arch Toxicol Suppl, Vol: 9, Pages: 27-37, ISSN: 0171-9750
The biological effects of simple molecules have traditionally been ascribed to their actions on the lipid portions of biological membranes. However, at the low concentrations of these molecules which induce general anaesthesia or have acute toxic effects in animals, changes in lipid bilayer properties are so small that they are unlikely to be relevant biologically. On the other hand, these molecules do inhibit the activity of a pure lipid-free protein, with ED50 concentrations which are essentially identical to the biological ED50 and LD50 concentrations. Moreover, the well-known but puzzling cutoffs in potencies in homologous series of compounds are also found with this enzyme. The accumulating evidence now suggests that the pharmacological effects of low concentrations of relatively inert agents are best explained in terms of their direct binding to amphiphilic pockets of circumscribed dimensions on proteins.
FRANKS NP, LIEB WR, 1985, MAPPING OF GENERAL ANESTHETIC TARGET SITES PROVIDES A MOLECULAR-BASIS FOR CUTOFF EFFECTS, NATURE, Vol: 316, Pages: 349-351, ISSN: 0028-0836
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- Citations: 233
MACNAUGHTAN W, SNOOK KA, CASPI E, et al., 1985, AN X-RAY-DIFFRACTION ANALYSIS OF ORIENTED LIPID MULTILAYERS CONTAINING BASIC-PROTEINS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 818, Pages: 132-148, ISSN: 0006-3002
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- Citations: 61
FRANKS NP, LIEB WR, 1985, THE FIREFLY THROWS LIGHT ON ANESTHESIA, CHEMISTRY IN BRITAIN, Vol: 21, Pages: 919-921, ISSN: 0009-3106
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- Citations: 10
FRANKS NP, 1984, X-RAY AND NEUTRON-DIFFRACTION FROM LIPID BILAYERS AND RECONSTITUTED MEMBRANES, HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, Vol: 365, Pages: 233-233, ISSN: 0018-4888
FRANKS NP, LIEB WR, 1984, DO GENERAL-ANESTHETICS ACT BY COMPETITIVE-BINDING TO SPECIFIC RECEPTORS, NATURE, Vol: 310, Pages: 599-601, ISSN: 0028-0836
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- Citations: 517
FRANKS NP, SNOOK KA, 1983, THE STRUCTURE AND PERMEABILITY OF RECONSTITUTED MEMBRANES, THIN SOLID FILMS, Vol: 99, Pages: 139-139, ISSN: 0040-6090
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- Citations: 2
FRANKS NP, MELCHIOR V, KIRSCHNER DA, et al., 1982, STRUCTURE OF MYELIN LIPID BILAYERS - CHANGES DURING MATURATION, JOURNAL OF MOLECULAR BIOLOGY, Vol: 155, Pages: 133-153, ISSN: 0022-2836
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- Citations: 35
FRANKS NP, LIEB WR, 1982, MOLECULAR MECHANISMS OF GENERAL-ANESTHESIA, NATURE, Vol: 300, Pages: 487-493, ISSN: 0028-0836
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- Citations: 447
Franks NP, Levine YK, 1981, Low-angle x-ray diffraction., Mol Biol Biochem Biophys, Vol: 31, Pages: 437-487, ISSN: 0077-0221
FRANKS NP, LIEB WR, 1981, IS MEMBRANE EXPANSION RELEVANT TO ANESTHESIA, NATURE, Vol: 292, Pages: 248-251, ISSN: 0028-0836
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- Citations: 99
FRANKS NP, 1980, CORRECTION, JOURNAL OF MOLECULAR BIOLOGY, Vol: 136, Pages: 101-102, ISSN: 0022-2836
FRANKS NP, LIEB WR, 1980, RAPID MOVEMENT OF MOLECULES ACROSS MEMBRANES - MEASUREMENT OF THE PERMEABILITY COEFFICIENT OF WATER USING NEUTRON-DIFFRACTION, JOURNAL OF MOLECULAR BIOLOGY, Vol: 141, Pages: 43-61, ISSN: 0022-2836
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- Citations: 8
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