Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

263 results found

Coughtrie MWH, Dajani R, Kauffman FC, Rubin GL, Sharp Set al., 1998, Sulfotransferases and the biology of sulfation, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 89-100, ISSN: 0929-6743

Conference paper

Cowan DA, Laidler P, 1998, Mass spectrometry in drug metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 159-174, ISSN: 0929-6743

Conference paper

Gooderham NJ, Lynch AM, Yadollahi-Farsani M, Murray S, Boobis A, Davies DSet al., 1998, Metabolism and genotoxicity of food-derived heterocyclic amines, Drug Metabolism: Towards the next Millennium, Editors: Gooderham, Amsterdam, Publisher: IOS Press, Pages: 127-136

Book chapter

Sandler M, 1998, The role of amine oxidases in xenobiotic metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 53-58, ISSN: 0929-6743

Conference paper

Beedham C, 1998, Oxidation of carbon via molybdenum hydroxylases, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 39-52, ISSN: 0929-6743

Conference paper

Campbell B, 1998, The use of kinetic and metabolic predictions in drug development, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 144-158, ISSN: 0929-6743

Conference paper

Tucker GT, 1998, Clinical aspects of polymorphic drug metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 109-118, ISSN: 0929-6743

Conference paper

Patterson LH, Raleigh SM, 1998, Reductive metabolism: its application in prodrug activation, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 72-79, ISSN: 0929-6743

Conference paper

Gibson GG, 1998, Recombinant DNA methods in drug metabolism and toxicology, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 13-23, ISSN: 0929-6743

Conference paper

Cupid BC, Garner RC, 1998, Accelerator mass spectrometry - A new tool for drug metabolism studies, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 175-187, ISSN: 0929-6743

Conference paper

Javan CM, Gooderham NJ, Edwards RJ, Davies DS, Shaunak Set al., 1997, Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 13, Pages: 875-880, ISSN: 0889-2229

Journal article

Gooderham NJ, Murray S, Lynch AM, YadollahiFarsani M, Zhao K, Rich K, Boobis AR, Davies DSet al., 1997, Assessing human risk to heterocyclic amines, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 376, Pages: 53-60, ISSN: 0027-5107

Journal article

Crosbie SJ, Boobis AR, Gooderham NJ, 1997, Analysis of the N-(deoxyguanosin-8-yl) adduct of the food derived carcinogen PhIP using capillary electrophoresis., Biochem Soc Trans, Vol: 25, ISSN: 0300-5127

Journal article

Gooderham NJ, 1997, The metabolism of heterocyclic amines., ECP News, Vol: 31, Pages: 24-27

Journal article

Lynch AM, Gooderham NJ, Boobis AR, 1996, Organ distinctive mutagenicity in muta(TM)mouse after short-term exposure to PhIP, MUTAGENESIS, Vol: 11, Pages: 505-509, ISSN: 0267-8357

Journal article

Gooderham NJ, Murray S, Lynch AM, Edwards RJ, YadollahiFarsani M, Bratt C, Rich KJ, Zhao K, Murray BP, Bhadresa S, Crosbie SJ, Boobis AR, Davies DSet al., 1996, Heterocyclic amines: Evaluation of their role in diet associated human cancer, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 42, Pages: 91-98, ISSN: 0306-5251

Journal article

YadollahiFarsani M, Gooderham NJ, Davies DS, Boobis ARet al., 1996, Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus, CARCINOGENESIS, Vol: 17, Pages: 617-624, ISSN: 0143-3334

Journal article

Rich KJ, Zhao K, Davies DS, Boobis AR, Gooderham NJet al., 1996, Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline in rabbit, CARCINOGENESIS, Vol: 17, Pages: 555-558, ISSN: 0143-3334

Journal article

Boobis AR, Gooderham NJ, Edwards RJ, Murray S, Lynch AM, YadollahiFarsani M, Davies DSet al., 1996, Enzymic and interindividual differences in the human metabolism of heterocyclic amines, TOXICOLOGY - FROM CELLS TO MAN, Vol: 18, Pages: 286-302

Journal article

Davies DS, Gooderham NJ, Murray S, Lynch A, delaTorre R, Segura J, Boobis ARet al., 1996, Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man, TOXICOLOGY - FROM CELLS TO MAN, Vol: 18, Pages: 251-258

Journal article

Lynch AM, Murray S, Gooderham NJ, Boobis ARet al., 1995, Exposure to and activation of dietary heterocyclic amines in humans, CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, Vol: 21, Pages: 19-31, ISSN: 1040-8428

Journal article

WATSON K, EDWARDS RJ, SHAUNAK S, PARMELEE DC, SARRAF C, GOODERHAM NJ, DAVIES DSet al., 1995, EXTRA-NUCLEAR LOCATION OF HISTONES IN ACTIVATED HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AND CULTURED T-CELLS, BIOCHEMICAL PHARMACOLOGY, Vol: 50, Pages: 299-309, ISSN: 0006-2952

Journal article

Boobis AR, Gooderham NJ, Rich KJ, Zhao K, Edwards RJ, Murray BP, Lynch AM, Murray S, Davies DSet al., 1995, Enzymatic studies of the activation of heterocyclic food mutagens in man., Princess Takamatsu Symp, Vol: 23, Pages: 134-144

2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are amongst the most abundant of the heterocyclic aromatic amines formed during the cooking of beef. Both compounds are genotoxic and carcinogenic in rodents. These effects are manifested only after activation of the amines by P450. Human liver is very active at converting these amines to mutagenic products. Studies in vitro have established that, for both amines, mutagenicity with human liver microsomes is entirely via the N-hydroxylamine, essentially the only oxidation product of either amine. Both N-hydroxylation and mutagenicity of the amines can be almost completely inhibited by furafylline, a potent and highly selective inhibitor of CYP1A2 in man. These data, together with the work of others, show that the N-hydroxylation and hence the mutagenicity of both MeIQx and PhIP in man is catalyzed almost exclusively by CYP1A2. Liver from cynomolgus monkeys, unlike that from humans and marmosets, is very poor at activating MeIQx or PhIP to mutagenic products. Studies with anti-peptide antibodies of defined specificity revealed that this is due to the absence of CYP1A2, suggesting that this species should not be used to assess the possible risk posed to man by these amines. The marmoset would be a better species for this purpose.

Journal article

Davies DS, Gooderham NJ, Murray S, Lynch A, de la Torre R, Segura J, Boobis ARet al., 1995, Systemic exposure to dietary heterocyclic amines in man., Princess Takamatsu Symp, Vol: 23, Pages: 190-196

2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-I-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are formed during the cooking of meat and account for a significant proportion of the mutagenic material present in cooked beef. The amines are not directly mutagenic but are converted to active intermediates by P450. Studies in vitro with human liver have shown that N-hydroxylation catalyzed by CYP1A2 is the major pathway of oxidation of MeQx and PhIP and is solely responsible for the generation of mutagenic species. In the studies reported in this paper it is demonstrated that both MelIQx and PhIP are well absorbed and extensively metabolized following ingestion of amine-containing beef by humans. Experiments with furafylline, a potent and selective inhibitor of human CYP1A2, reveal that more than 90% of MeIQx and 70% of PhIP are N-hydroxylated in vivo, probably presystemically in the liver.

Journal article

SHAUNAK S, GOODERHAM NJ, EDWARDS RJ, PAYVANDI N, JAVAN CM, BAGGETT N, MACDERMOT J, WEBER JN, DAVIES DSet al., 1994, INFECTION BY HIV-1 BLOCKED BY BINDING OF DEXTRIN 2-SULFATE TO THE CELL-SURFACE OF ACTIVATED HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND CULTURED T-CELLS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 113, Pages: 151-158, ISSN: 0007-1188

Journal article

ZHAO K, MURRAY S, DAVIES DS, BOOBIS AR, GOODERHAM NJet al., 1994, METABOLISM OF THE FOOD-DERIVED MUTAGEN AND CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (PHIP) BY HUMAN LIVER-MICROSOMES, CARCINOGENESIS, Vol: 15, Pages: 1285-1288, ISSN: 0143-3334

Journal article

WATSON K, EDWARDS RJ, PARMELEE DC, SHAUNAK S, GOODERHAM NJ, DAVIES DSet al., 1994, HISTONES LOCATED ON THE PLASMA-MEMBRANE OF T-CELLS, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 22, Pages: S199-S199, ISSN: 0300-5127

Journal article

ZHAO KC, BOOBIS AR, DAVIES DS, GOODERHAM NJet al., 1994, THE ROLE OF CYP1A ENZYMES IN MURINE ACTIVATION OF THE COOKED FOOD CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 22, Pages: S128-S128, ISSN: 0300-5127

Journal article

BROOKS RA, GOODERHAM NJ, ZHAO KC, EDWARDS RJ, HOWARD LA, BOOBIS AR, WINTON DJet al., 1994, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE IS A POTENT MUTAGEN IN THE MOUSE SMALL-INTESTINE, CANCER RESEARCH, Vol: 54, Pages: 1665-1671, ISSN: 0008-5472

Journal article

BOOBIS AR, LYNCH AM, MURRAY S, DELATORRE R, SOLANS A, FARRE M, SEGURA J, GOODERHAM NJ, DAVIES DSet al., 1994, CYP1A2-CATALYZED CONVERSION OF DIETARY HETEROCYCLIC AMINES TO THEIR PROXIMATE CARCINOGENS IS THEIR MAJOR ROUTE OF METABOLISM IN HUMANS, CANCER RESEARCH, Vol: 54, Pages: 89-94, ISSN: 0008-5472

Journal article

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