Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rietjens:2020:10.1016/j.fct.2019.110949,
author = {Rietjens, IMCM and Cohen, SM and Eisenbrand, G and Fukushima, S and Gooderham, NJ and Guengerich, FP and Hecht, SS and Rosol, TJ and Davidsen, JM and Harman, CL and Murray, IJ and Taylor, SV},
doi = {10.1016/j.fct.2019.110949},
journal = {Food and Chemical Toxicology},
title = {FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients},
url = {http://dx.doi.org/10.1016/j.fct.2019.110949},
volume = {135},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, third in the series, considers NFCs composed primarily of constituents with the 3-phenyl-2-propenyl or a cinnamyl functional group, using the procedure outlined in 2005 and updated in 2018 to evaluate the safety of naturally-occurring mixtures for their intended use as flavor ingredients. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of each NFC's chemical constituents into well-defined congeneric groups. The safety of the NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism, and toxicology of members of the congeneric groups and the NFC under evaluation. Six NFCs from the Myroxylon and Cinnamomum genera, Balsam Oil, Peru (FEMA 2117), Tolu Balsam Extract (FEMA 3069), Cassia Bark Extract (FEMA 2257), Cassia Bark Oil (FEMA 2258), Cinnamon Bark Extract (FEMA 2290) and Cinnamon Bark Oil (FEMA 2291) were evaluated and affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients.
AU  - Rietjens,IMCM
AU  - Cohen,SM
AU  - Eisenbrand,G
AU  - Fukushima,S
AU  - Gooderham,NJ
AU  - Guengerich,FP
AU  - Hecht,SS
AU  - Rosol,TJ
AU  - Davidsen,JM
AU  - Harman,CL
AU  - Murray,IJ
AU  - Taylor,SV
DO  - 10.1016/j.fct.2019.110949
PY  - 2020///
SN  - 0278-6915
TI  - FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients
T2  - Food and Chemical Toxicology
UR  - http://dx.doi.org/10.1016/j.fct.2019.110949
UR  - https://www.sciencedirect.com/science/article/pii/S0278691519307392?via%3Dihub
UR  - http://hdl.handle.net/10044/1/75370
VL  - 135
ER  -
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