Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Butler:2020:10.3389/fendo.2020.00206,
author = {Butler, AE and Ramachandran, V and Sathypalan, T and David, R and Gooderham, NJ and Benurwar, M and Dargham, SR and Hayat, S and Hani, Najafi-Shoushtari S and Atkin, SL},
doi = {10.3389/fendo.2020.00206},
journal = {Frontiers in Endocrinology},
pages = {1--8},
title = {microRNA expression in women with and without polycystic ovarian syndrome matched for body mass index},
url = {http://dx.doi.org/10.3389/fendo.2020.00206},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Despite several authors who have hypothesized that alterations of smallnoncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovariansyndrome (PCOS), contrasting findings have been reported so far. Discrepancies in bodymass index (BMI) levels may account for these differences; therefore, the aim of thepresent study was to determine whether miR differed in serum samples collected fromage- and BMI-matched control and PCOS women.Methods: In a cross-sectional study, miR were measured using quantitative polymerasechain reaction in 29 women with anovulatory PCOS women and 29 control women whowere in the follicular phase of their menstrual cycle, from the local biobank.Results: One hundred seventy-six miR were detected, of which 15 miR passed the falsediscovery rate (FDR; p < 0.05) that differed between PCOS and control women. Therewas no association of the top 9 miR (p < 0.02) (miR-486-5p, miR-24-3p, miR-19b-3p,miR-22-3p, miR-19a-3p, miR-339-5p, miR-185-5p, miR-101-3p, miR-let-7i-5p) withBMI, androgen levels, insulin resistance, or antimullerian hormone (AMH) in eitherPCOS or normal women. Ingenuity pathway assessment showed the pathways wereinterrelated for abnormalities of the reproductive system.Conclusion: When the confounding influence of weight was accounted for, miR levelsdiffered between anovulatory PCOS women and control women in the follicular phase ofthe menstrual cycle. Interestingly, the differing miR were associated with the pathways ofreproductive abnormalities but did not associate with AMH or metabolic parameters.
AU  - Butler,AE
AU  - Ramachandran,V
AU  - Sathypalan,T
AU  - David,R
AU  - Gooderham,NJ
AU  - Benurwar,M
AU  - Dargham,SR
AU  - Hayat,S
AU  - Hani,Najafi-Shoushtari S
AU  - Atkin,SL
DO  - 10.3389/fendo.2020.00206
EP  - 8
PY  - 2020///
SN  - 1664-2392
SP  - 1
TI  - microRNA expression in women with and without polycystic ovarian syndrome matched for body mass index
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2020.00206
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2020.00206/full
UR  - http://hdl.handle.net/10044/1/78623
VL  - 11
ER  -
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