Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rietjens:2023:10.1016/j.fct.2023.113643,
author = {Rietjens, IMCM and Cohen, SM and Eisenbrand, G and Fukushima, S and Gooderham, NJ and Guengerich, FP and Hecht, SS and Rosol, TJ and Davidsen, JM and Harman, CL and Taylor, SV},
doi = {10.1016/j.fct.2023.113643},
journal = {Food and Chemical Toxicology},
pages = {1--26},
title = {FEMA GRAS assessment of natural flavor complexes: allspice, anise, fennel-derived and related flavoring ingredients},
url = {http://dx.doi.org/10.1016/j.fct.2023.113643},
volume = {174},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The FEMA Expert Panel program to re-evaluate the safety of natural flavor complexes (NFCs) used as flavoring ingredients in food has resulted in the publication of an updated constituent-based procedure as well as publications on the safety evaluation of many botanical-derived NFCs. This publication, ninth in the series and related to the ninth publication, describes the affirmation of the generally recognized as safe (GRAS) status for NFCs with propenylhydroxybenzene and allylalkoxybenzene constituents under their conditions of intended use as flavoring ingredients added to food. The Panel's procedure applies the threshold of toxicological concern (TTC) concept and evaluates relevant data on absorption, metabolism, genotoxic potential and toxicology for the NFCs themselves and their respective constituent congeneric groups. For NFCs containing allylalkoxybenzene constituent(s) with suspected genotoxic potential, the estimated intake of the individual constituent is compared to the TTC for compounds with structural alerts for genotoxicity and if exceeded, a margin of exposure is calculated using BMDL10 values derived from benchmark dose analyses using Bayesian model averaging, as presented in the tenth article of the series. Safety evaluations for NFCs derived from allspice, anise seed, star anise, sweet fennel seed and pimento leaves were conducted and their GRAS status was affirmed for use as flavoring ingredients. The scope of the safety evaluation contained herein does not include added use in dietary supplements or any products other than food.
AU  - Rietjens,IMCM
AU  - Cohen,SM
AU  - Eisenbrand,G
AU  - Fukushima,S
AU  - Gooderham,NJ
AU  - Guengerich,FP
AU  - Hecht,SS
AU  - Rosol,TJ
AU  - Davidsen,JM
AU  - Harman,CL
AU  - Taylor,SV
DO  - 10.1016/j.fct.2023.113643
EP  - 26
PY  - 2023///
SN  - 0278-6915
SP  - 1
TI  - FEMA GRAS assessment of natural flavor complexes: allspice, anise, fennel-derived and related flavoring ingredients
T2  - Food and Chemical Toxicology
UR  - http://dx.doi.org/10.1016/j.fct.2023.113643
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36739890
UR  - https://www.sciencedirect.com/science/article/pii/S0278691523000455?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102871
VL  - 174
ER  -
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