Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davidsen:2023:10.1016/j.fct.2023.113646,
author = {Davidsen, JM and Cohen, SM and Eisenbrand, G and Fukushima, S and Gooderham, NJ and Guengerich, FP and Hecht, SS and Rietjens, IMCM and Rosol, TJ and Harman, CL and Taylor, SV},
doi = {10.1016/j.fct.2023.113646},
journal = {Food and Chemical Toxicology},
pages = {113646--113646},
title = {FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes},
url = {http://dx.doi.org/10.1016/j.fct.2023.113646},
volume = {175},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavoring ingredients in food. In this publication, ninth in the series, NFCs containing a high percentage of least one naturally occurring allylalkoxybenzene constituent with a suspected concern for genotoxicity and/or carcinogenicity are evaluated. In a related paper, tenth in the series, NFCs containing anethole and/or eugenol and relatively low percentages of these allylalkoxybenzenes are evaluated. The Panel applies the threshold of toxicological concern (TTC) concept and evaluates relevant toxicology data on the NFCs and their respective constituent congeneric groups. For NFCs containing allylalkoxybenzene constituent(s), the estimated intake of the constituent is compared to the TTC for compounds with structural alerts for genotoxicity and when exceeded, a margin of exposure (MOE) is calculated. BMDL10 values are derived from benchmark dose analyses using Bayesian model averaging for safrole, estragole and methyl eugenol using EPA's BMDS software version 3.2. BMDL10 values for myristicin, elemicin and parsley apiole were estimated by read-across using relative potency factors. Margins of safety for each constituent congeneric group and MOEs for each allylalkoxybenzene constituent for each NFC were determined that indicate no safety concern. The scope of the safety evaluation contained herein does not include added use in dietary supplements or any products other than food. Ten NFCs, derived from basil, estragon (tarragon), mace, nutmeg, parsley and Canadian snakeroot were determined or affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients based on an evaluation of each NFC and the constituents and congeneric groups therein.
AU  - Davidsen,JM
AU  - Cohen,SM
AU  - Eisenbrand,G
AU  - Fukushima,S
AU  - Gooderham,NJ
AU  - Guengerich,FP
AU  - Hecht,SS
AU  - Rietjens,IMCM
AU  - Rosol,TJ
AU  - Harman,CL
AU  - Taylor,SV
DO  - 10.1016/j.fct.2023.113646
EP  - 113646
PY  - 2023///
SN  - 0278-6915
SP  - 113646
TI  - FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes
T2  - Food and Chemical Toxicology
UR  - http://dx.doi.org/10.1016/j.fct.2023.113646
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36804339
UR  - https://www.sciencedirect.com/science/article/pii/S0278691523000480
UR  - http://hdl.handle.net/10044/1/102916
VL  - 175
ER  -
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