Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cohen:2016:10.1016/j.fct.2016.10.023,
author = {Cohen, SM and Fukushima, S and Gooderham, NJ and Guengerich, FP and Hecht, SS and Rietjens, IM and Smith, RL and Bastaki, M and Harman, CL and McGowen, MM and Valerio, LG and Taylor, SV},
doi = {10.1016/j.fct.2016.10.023},
journal = {Food and Chemical Toxicology},
pages = {40--59},
title = {Safety evaluation of substituted thiophenes used as flavoring ingredients.},
url = {http://dx.doi.org/10.1016/j.fct.2016.10.023},
volume = {99},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This publication is the second in a series by the Expert Panel of the Flavor and Extract Manufacturers Association summarizing the conclusions of its third systematic re-evaluation of the safety of flavorings previously considered to be generally recognized as safe (GRAS) under conditions of intended use. Re-evaluation of GRAS status for flavorings is based on updated considerations of exposure, structural analogy, metabolism, pharmacokinetics and toxicology and includes a comprehensive review of the scientific information on the flavorings and structurally related substances. Of the 12 substituted thiophenes reviewed here, 11 were reaffirmed as GRAS based on their rapid absorption, metabolism and excretion in humans and animals; the low estimated dietary exposure from flavor use; the wide margins of safety between the conservative estimates of intake and the no-observed-adverse effect levels; and the lack of significant genotoxic and mutagenic potential. For one of the substituted thiophenes, 3-acetyl-2,5-dimethylthiophene, it was concluded that more detailed exposure information, comparative metabolism studies and comprehensive toxicity data, including an in-depth evaluation of the mechanism of action for any adverse effects observed, are required for continuation of its FEMA GRAS™ status. In the absence of these data, the compound was removed from the FEMA GRAS list.
AU  - Cohen,SM
AU  - Fukushima,S
AU  - Gooderham,NJ
AU  - Guengerich,FP
AU  - Hecht,SS
AU  - Rietjens,IM
AU  - Smith,RL
AU  - Bastaki,M
AU  - Harman,CL
AU  - McGowen,MM
AU  - Valerio,LG
AU  - Taylor,SV
DO  - 10.1016/j.fct.2016.10.023
EP  - 59
PY  - 2016///
SN  - 1873-6351
SP  - 40
TI  - Safety evaluation of substituted thiophenes used as flavoring ingredients.
T2  - Food and Chemical Toxicology
UR  - http://dx.doi.org/10.1016/j.fct.2016.10.023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27836750
UR  - http://hdl.handle.net/10044/1/42811
VL  - 99
ER  -
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