Imperial College London
Alternate

Emeritus ProfessorNigelGooderham

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Toxicology
 
 
 
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Contact

 

n.gooderham Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harling:2017:10.1186/s13019-017-0632-2,
author = {Harling, L and Athanasiou, T and Ashrafian, H and Darzi, A and Gooderham, N and Lambert, J},
doi = {10.1186/s13019-017-0632-2},
journal = {Journal of Cardiothoracic Surgery},
title = {Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting},
url = {http://dx.doi.org/10.1186/s13019-017-0632-2},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveSystemic inflammation is a recognised contributory factor in the pathogenesis of de novo post-operative atrial fibrillation after cardiac surgery. This study aims to determine whether serum soluble vascular endothelial cell adhesion molecule (sVCAM-1) may predict the onset of POAF in patients under going coronary artery bypass grafting.Methods34 patients undergoing non-emergent, on-pump CABG were prospectively recruited. Plasma was obtained at 24 h pre-operatively and at 48 and 96 h post-operatively. POAF was defined by continuous Holter recording. Inter-group comparisons were performed using student t-test or ANOVA as appropriate.ResultsThirteen (13/34) patients developed POAF at a mean of 2.5 days post-operatively. Serum sVCAM-1 was significantly increased in the pre-operative serum of POAF when compared to non-POAF patients (p = 0.022). No significant difference was observed between the groups at 48 h (p = 0.073) or 96 h (p = 0.135) post-operatively. sVCAM-1 had a sensitivity of 60.0% and specificity of 77.27%, with an overall diagnostic accuracy of 75.2% in predicting POAF.ConclusionssVCAM-1 concentration in the pre-operative serum of patients undergoing CABG may accurately predict the onset of de novo POAF. As such, serum sVCAM-1 may be used as a predictive biomarker for this common arrhythmia. Further work must now perform prospective, targeted validation of these results in a larger patient cohort.
AU  - Harling,L
AU  - Athanasiou,T
AU  - Ashrafian,H
AU  - Darzi,A
AU  - Gooderham,N
AU  - Lambert,J
DO  - 10.1186/s13019-017-0632-2
PY  - 2017///
SN  - 1749-8090
TI  - Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting
T2  - Journal of Cardiothoracic Surgery
UR  - http://dx.doi.org/10.1186/s13019-017-0632-2
UR  - http://hdl.handle.net/10044/1/50325
VL  - 12
ER  -
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