Imperial College London
Alternate

DrNikolaosGorgoraptis

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Lecturer
 
 
 
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Contact

 

n.gorgoraptis

 
 
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Location

 

C3NLBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Mallas:2021:10.1101/2021.12.24.21268337,
author = {Mallas, E-J and Gorgoraptis, N and Dautricourt, S and Pertzov, Y and Scott, G and Sharp, D},
doi = {10.1101/2021.12.24.21268337},
publisher = {medRxiv},
title = {Pathological slow-wave activity and impaired working memory binding in post-traumatic amnesia},
url = {http://dx.doi.org/10.1101/2021.12.24.21268337},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - The mechanism by which information is bound together in working memory is a central question for cognitive neuroscience. This binding is transiently disrupted during periods of post-traumatic amnesia following significant head injuries. The reason for this impairment is unclear but may be due to electrophysiological changes produced by head impacts. These are common and include pathological low frequency activity, which is associated with poorer neurological outcomes and may disrupt cortical communication. Here, we investigate associative memory binding during post-traumatic amnesia and test the hypothesis that misbinding is caused by a disruption in cortical communication produced by the pathological slowing of brain activity. Thirty acute moderate-severe traumatic brain injury patients (mean time since injury = 10 days) and 26 healthy controls were tested with a precision working memory paradigm that required the association of object and location information. A novel entropy ratio measure was calculated from behavioural performance. This provided a continuous measure of the degree of misbinding and the influence of distracting information. Resting state EEG was used to assess the electrophysiological effects of traumatic brain injury. Patients in post-traumatic amnesia showed abnormalities in working memory function and made significantly more misbinding errors than patients who were not in post-traumatic amnesia and controls. Patients showed a higher entropy ratio in the distribution of spatial responses, indicating that working memory recall was abnormally biased by the locations of non-target items suggesting a specific impairment of object and location binding. Slow wave activity was increased following traumatic brain injury. Increases in the delta-alpha ratio indicative of an increase in low frequency power specifically correlated with binding impairment in working memory. In contrast, although connectivity was increased in the theta band and decreased in t
AU  - Mallas,E-J
AU  - Gorgoraptis,N
AU  - Dautricourt,S
AU  - Pertzov,Y
AU  - Scott,G
AU  - Sharp,D
DO  - 10.1101/2021.12.24.21268337
PB  - medRxiv
PY  - 2021///
TI  - Pathological slow-wave activity and impaired working memory binding in post-traumatic amnesia
UR  - http://dx.doi.org/10.1101/2021.12.24.21268337
UR  - https://www.medrxiv.org/content/10.1101/2021.12.24.21268337v1.full.pdf+html
UR  - http://hdl.handle.net/10044/1/100896
ER  -
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