Imperial College London
Alternate

DrNikolaosGorgoraptis

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Lecturer
 
 
 
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Contact

 

n.gorgoraptis

 
 
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Location

 

C3NLBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Freund:2012:10.1136/jnnp-2011-301875,
author = {Freund, P and Wheeler-Kingshott, CA and Nagy, Z and Gorgoraptis, N and Weiskopf, N and Friston, K and Thompson, AJ and Hutton, C},
doi = {10.1136/jnnp-2011-301875},
journal = {Journal of Neurology Neurosurgery and Psychiatry},
pages = {629--637},
title = {Axonal integrity predicts cortical reorganisation following cervical injury.},
url = {http://dx.doi.org/10.1136/jnnp-2011-301875},
volume = {83},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment. OBJECTIVE: The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish how microstructural white matter changes in the CST are related to cross-sectional spinal cord area and cortical reorganisation of the sensorimotor system in subjects with traumatic SCI. METHODS: Nine volunteers with cervical injuries resulting in bilateral motor impairment and 14 control subjects were studied. The authors used diffusion tensor imaging to assess white matter integrity in the CST, T1-weighted imaging to measure cross-sectional spinal cord area and functional MRI to compare motor task-related brain activations. The relationships among microstructural, macrostructural and functional measures were assessed using regression analyses. Results Diffusion tensor imaging revealed significant differences in the CST of SCI subjects-compared with controls-in the pyramids, the internal capsule, the cerebral peduncle and the hand area. The microstructural white matter changes observed in the left pyramid predicted increased task-related responses in the left M1 leg area, while changes in the cerebral peduncle were predicted by reduced cord area. CONCLUSION: The observed microstructural changes suggest trauma-related axonal degeneration and demyelination, which are related to cortical motor reorganisation and macrostructure. The extent of these changes may reflect the plasticity of motor pathways associated with cortical reorganisation. This clinically viable multimodal imaging approach is therefore appropriate for monitoring degeneration of central pathways and the evaluation of treatments targeting axonal repair in SCI.
AU  - Freund,P
AU  - Wheeler-Kingshott,CA
AU  - Nagy,Z
AU  - Gorgoraptis,N
AU  - Weiskopf,N
AU  - Friston,K
AU  - Thompson,AJ
AU  - Hutton,C
DO  - 10.1136/jnnp-2011-301875
EP  - 637
PY  - 2012///
SN  - 1468-330X
SP  - 629
TI  - Axonal integrity predicts cortical reorganisation following cervical injury.
T2  - Journal of Neurology Neurosurgery and Psychiatry
UR  - http://dx.doi.org/10.1136/jnnp-2011-301875
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22492214
UR  - http://hdl.handle.net/10044/1/42729
VL  - 83
ER  -
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