Nicholas Grassly is a Professor in the Department for Infectious Disease Epidemiology, head of the Vaccine Epidemiology Research Group and associate director of the MRC Centre for Global Infectious Disease Analysis. He works on vaccine trials and disease surveillance. His research brings together epidemiological analysis and laboratory testing to identify optimal methods for disease prevention, focusing on pathogens in low- and middle-income countries such as polio, rotavirus and typhoid. He works with a network of collaborators at institutes worldwide, including in the UK, DRC, France, Ghana, India, Malawi, Pakistan and Zambia.
He studied biology at Oxford University, trained in epidemiology at Imperial College London and learnt mathematics with the Open University. He was a Royal Society URF (2004-2011) and then Professor at Imperial College London (2011-present). He has served on various boards and committees, including the MRC Infections and Immunity Board (2012-16), the WHO SAGE polio group (2008-2020) and WHO SAGE COVID-19 vaccines working group (2020-2021). He teaches on the MSc (Epidemiology), MPH and undergraduate biomedical courses at Imperial College London. His work is funded by the MRC, Wellcome Trust, Royal Society, WHO and the Bill and Melinda Gates Foundation.
Current research topics: Rapid diagnostics for poliovirus surveillance; Epidemiology of polio eradication and endgame strategy; Environmental surveillance; Vaccine clinical trial design; Causes of oral vaccine failure (rotavirus and poliovirus); Human infection challenge for vaccine development; Typhoid epidemiology
et al., 2022, Reassessing reported deaths and estimated infection attack rate during the first 6 months of the COVID-19 epidemic, Delhi, India., Emerging Infectious Diseases, Vol:28, ISSN:1080-6040
et al., 2022, Risk factors for the spread of vaccine-derived type 2 polioviruses after global withdrawal of trivalent oral poliovirus vaccine and the effects of outbreak responses with monovalent vaccine: a retrospective analysis of surveillance data for 51 countries in Africa, Lancet Infectious Diseases, Vol:22, ISSN:1473-3099, Pages:284-294
et al., 2021, Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants, Nature Communications, Vol:12
et al., 2021, Salmonella Typhi Shedding and Household Transmission by Children With Blood Culture-Confirmed Typhoid Fever in Vellore, South India, Journal of Infectious Diseases, Vol:224, ISSN:0022-1899, Pages:S593-S600
et al., 2021, Factors Predicting Blood Culture Positivity Children With Enteric Fever, Journal of Infectious Diseases, Vol:224, ISSN:0022-1899, Pages:S484-S493