Nicholas Grassly is a Professor in the Department for Infectious Disease Epidemiology. He is interested in the individual immune response to vaccination – particularly for enteric infections such as enteroviruses (including poliovirus) and rotavirus – and how this translates to impact at the population level. His research group conduct both laboratory and population studies, including clinical trials with collaborators in the UK and India. A strength of his group is the development and use of rigorous statistical methods and mathematical models to analyse study data. His group is the WHO collaborating institute on polio data analysis and modelling.
He studied biology at Oxford University, trained in epidemiology at Imperial College London and learnt mathematics with the Open University. He was a Royal Society URF (2004-2011) and then Professor at Imperial College London (2011-present). He has served on various boards and committees, including the MRC Infections and Immunity Board (2012-16) and the WHO SAGE polio group (2008-present). He teaches on the MSc (Epidemiology), MPH and undergraduate biomedical courses at Imperial College London. His work is funded by the MRC, Wellcome Trust, Royal Society and the Bill and Melinda Gates Foundation.
Current research topics: Epidemiology of polio eradication and endgame strategy; Rapid diagnostics and nanopore sequencing for poliovirus surveillance; Epidemiology and evolution of non-polio enteroviruses; Infant intestinal microbiome and immune response; causes of oral vaccine failure (rotavirus and poliovirus); phylodynamic methods; Typhoid epidemiology in India
et al., 2019, Vaccine schedules and the effect on humoral and intestinal immunity against poliovirus: a systematic review and network meta-analysis., Lancet Infectious Diseases, ISSN:1473-3099
et al., 2019, Influence of nonpolio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: A study from south India, Journal of Infectious Diseases, Vol:219, ISSN:0022-1899, Pages:1178-1186
et al., 2019, Interventions to improve oral vaccine performance: a systematic review and meta-analysis, Lancet Infectious Diseases, Vol:19, ISSN:1473-3099, Pages:203-214
et al., 2019, FUT2 secretor status is not associated with oral poliovirus vaccine immunogenicity in south Indian infants, Journal of Infectious Diseases, Vol:219, ISSN:0022-1899, Pages:578-581
et al., 2018, Effect of Inactivated Poliovirus Vaccine Campaigns, Pakistan, 2014-2017, Emerging Infectious Diseases, Vol:24, ISSN:1080-6040, Pages:2113-2115