Imperial College London

Dr Nadia Guerra

Faculty of Natural SciencesDepartment of Life Sciences




+44 (0)20 7594 5663n.guerra




604Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Guerra is an Assistant Professor and head of the "Inflammation and Cancer Immunity" lab in the Department of Life Sciences.  Her research aims to elucidate the physiologic relevance of Natural Killer cell Receptors (NK-R)  in the development of Immunopathologies and Cancer using preclinical models of disease.   The lab has recently uncovered a novel and unexpected role for NKG2D in its capacity to promote rather than delay tumorigenesis in models of inflammation-driven Cancer. An additional focus in the lab relies on combining state-of-the-art multi-photon imaging with novel mouse models to investigate the behaviour of NK cells during chronic inflammation with the view of understanding the role they play in cancer progression. 

Nadia received her Ph.D. from the University Paris VI, Pierre et Marie Curie, Paris  in 2002 where she studied the role of inhibitory NK cell receptors in kidney cancer under the supervision of Dr. Anne Caignard at the Institut Gustave Roussy in Villejuif, France.  Her studies evidenced the presence and regulatory function of inhibitory NK receptors KIR on CD8 T lymphocytes infiltrating Renal Cell Carcinoma. She then joined the group of Prof. David Raulet at the University of Berkeley, California to complete her postdoctoral training focusing on the role of NK group 2, member D (NKG2D) in vivo. She made a significant contribution to the NK cell field through the generation of NKG2D-deficient mice, instrumental to the understanding of NK cell function in disease models. In 2009, Nadia was awarded a prestigious Career Development Fellowship from the Wellcome Trust to establish her research group at Imperial College London.



* In collaboration with the Dunlop lab (Department of Materials), the Guerra lab is offering a 1 3 PhD fellowship from the Institute of Chemical Biology to investigate the use of nanoparticules to improve the anti-tumour function of Natural Killer cells. Apply here.

* The Guerra Lab  will partner with AstraZeneca to explore the feasibility of manipulating the NKG2D axis in particular model of liver cancer.

* On June 26th 2017, Nadia gave a talk at the EACR-AACR-SIC special conference on The Challenges of Optimising Immuno and Targeted Therapies : From cancer Biology to the Clinic"  that gathered over 850 scientists in Firenze, Italy.

Imperial Festival
* May 7th 2017 - Imperial Festival celebration at South Kensington campus. Nadia Guerra joins forces with the CRUK team to discuss novel therapeutic strategies against Cancer.

Joana's thesis

* On April 11th 2017, Joana Guedes successfully defended her Ph.D viva entitled "Role of NKG2D in models of liver inflammation and tumorigenesis" in front of examiners Dr. Keith Gould (ICL) and Prof. Mala Maini (UCL)

* Joana presented orally her work at the 7th annual NK-UK meeting held at UCL on January 2017.


* PhD student Sam Sheppard has now joined the lab of Dr. Joseph Sun at the Memorial Sloan Kettering Cancer Center in NY for his post-doctoral training. Oct 2016

* Dr. Guerra was invited to present recent findings of the lab on the novel role of NKG2D in Hepatocellular Carcinoma at the 16th annual meeting of the Society for Natural Immunity in Taormina, Sicily - Oct 2016.


Students (Ph.D or Post-doc level) interested in joining the lab should email their resume and cover letter to Dr Guerra (



Sheppard S, Ferry A, Guedes J, et al., 2018, The Paradoxical Role of NKG2D in Cancer Immunity, Frontiers in Immunology, Vol:9, ISSN:1664-3224

Sheppard S, Schuster IS, Andoniou CE, et al., 2018, The murine natural cytotoxic receptor NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1, Cell Reports, Vol:22, ISSN:2211-1247, Pages:3385-3392

Sheppard S, Guedes J, Mroz A, et al., 2017, The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma, Nature Communications, Vol:8, ISSN:2041-1723

Collery P, Mohsen A, Kermagoret A, et al., 2015, Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer, Investigational New Drugs, Vol:33, ISSN:1573-0646, Pages:848-860


Cadoux M, Pham S, Caruso S, et al., 2019, Beta-catenin signaling controls NKG2D ligands expression in liver tumorigenesis, International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), ELSEVIER SCIENCE BV, Pages:E354-E355, ISSN:0168-8278

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