Imperial College London
Dr Nadia Guerra

Dr Nadia Guerra

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5663n.guerra

 
 
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Location

 

604Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sheppard:2018:10.3389/fimmu.2018.01808,
author = {Sheppard, S and Ferry, A and Guedes, J and Guerra, N},
doi = {10.3389/fimmu.2018.01808},
journal = {Frontiers in Immunology},
pages = {1--19},
title = {The paradoxical role of NKG2D in cancer immunity},
url = {http://dx.doi.org/10.3389/fimmu.2018.01808},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The activating receptor NKG2D and its ligands are recognized as a potent immune axis that controls tumor growth and microbial infections. With regards to cancer surveillance, various studies have demonstrated the antitumor function mediated by NKG2D on natural killer cells and on conventional and unconventional T cells. The use of NKG2D-deficient mice established the importance of NKG2D in delaying tumor development in transgenic mouse models of cancer. However, we recently demonstrated an unexpected, flip side to this coin, the ability for NKG2D to contribute to tumor growth in a model of inflammation-driven liver cancer. With a focus on the liver, here, we review current knowledge of NKG2D-mediated tumor surveillance and discuss evidence supporting a dual role for NKG2D in cancer immunity. We postulate that in certain advanced cancers, expression of ligands for NKG2D can drive cancer progression rather than rejection. We propose that the nature of the microenvironment within and surrounding tumors impacts the outcome of NKG2D activation. In a form of autoimmune attack, NKG2D promotes tissue damage, mostly in the inflamed tissue adjacent to the tumor, facilitating tumor progression while being ineffective at rejecting transformed cells in the tumor bed.
AU  - Sheppard,S
AU  - Ferry,A
AU  - Guedes,J
AU  - Guerra,N
DO  - 10.3389/fimmu.2018.01808
EP  - 19
PY  - 2018///
SN  - 1664-3224
SP  - 1
TI  - The paradoxical role of NKG2D in cancer immunity
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2018.01808
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441422500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2018.01808/full
UR  - http://hdl.handle.net/10044/1/99985
VL  - 9
ER  -
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