Publications

BibTex format

@article{Pinato:2020:10.1038/s41388-020-1249-9,
author = {Pinato, DJ and Guerra, N and Fessas, P and Murphy, R and Mineo, T and Mauri, FA and Mukherjee, SK and Thursz, M and Wong, CN and Sharma, R and Rimassa, L},
doi = {10.1038/s41388-020-1249-9},
journal = {Oncogene},
pages = {3620--3637},
title = {Immune-based therapies for hepatocellular carcinoma},
url = {http://dx.doi.org/10.1038/s41388-020-1249-9},
volume = {39},
year = {2020}
}

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TY  - JOUR
AB  - Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential for patient stratification in an attempt to overcome the series of failures that has characterised drug development in this disease area.
AU  - Pinato,DJ
AU  - Guerra,N
AU  - Fessas,P
AU  - Murphy,R
AU  - Mineo,T
AU  - Mauri,FA
AU  - Mukherjee,SK
AU  - Thursz,M
AU  - Wong,CN
AU  - Sharma,R
AU  - Rimassa,L
DO  - 10.1038/s41388-020-1249-9
EP  - 3637
PY  - 2020///
SN  - 0950-9232
SP  - 3620
TI  - Immune-based therapies for hepatocellular carcinoma
T2  - Oncogene
UR  - http://dx.doi.org/10.1038/s41388-020-1249-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000518886000005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41388-020-1249-9
UR  - http://hdl.handle.net/10044/1/82256
VL  - 39
ER  -

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Dr Nadia Guerra

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