Imperial College London
Dr Nadia Guerra

Dr Nadia Guerra

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5663n.guerra

 
 
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Location

 

604Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Collery:2015:10.1007/s10637-015-0265-z,
author = {Collery, P and Mohsen, A and Kermagoret, A and Corre, S and Bastian, G and Tomas, A and Wei, M and Santoni, F and Guerra, N and Desmaele, D and d'Angelo, J},
doi = {10.1007/s10637-015-0265-z},
journal = {Investigational New Drugs},
pages = {848--860},
title = {Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer},
url = {http://dx.doi.org/10.1007/s10637-015-0265-z},
volume = {33},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rhenium (I)-diselenother (Re-diselenoether) is a water soluble metal-based compound, combining one atom of rhenium and two atoms of selenium. This compound has been reported to exhibit marked activities against several solid tumor cell lines. We now disclose an improved synthesis of this complex. The Re-diselenoether showed a potent inhibitory effect on MDA-MB231 cell division in vitro, which lasted when the complex was no longer present in the culture. Re-diselenoether induced a remarkable reduction of the volume of the primitive breast tumors and of the pulmonary metastases without clinical signs of toxicity, in mice-bearing a MDA-MB231 Luc+ tumor, orthotopically transplanted, after a daily oral administration at the dose of 10 mg/kg/d. Interestingly, an antagonism was observed when cisplatin was administered as a single i.p. injection 1 week after the end of the Re-diselenoether administration. In an effort to gain insight of the mechanisms of action of Re-diselenoether complex, interaction with 9-methylguanine as a nucleic acid base model was studied. We have shown that Re-diselenoether gave both mono- and bis-guanine Re adducts, the species assumed to be responsible for the DNA intrastrand lesions.
AU  - Collery,P
AU  - Mohsen,A
AU  - Kermagoret,A
AU  - Corre,S
AU  - Bastian,G
AU  - Tomas,A
AU  - Wei,M
AU  - Santoni,F
AU  - Guerra,N
AU  - Desmaele,D
AU  - d'Angelo,J
DO  - 10.1007/s10637-015-0265-z
EP  - 860
PY  - 2015///
SN  - 1573-0646
SP  - 848
TI  - Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer
T2  - Investigational New Drugs
UR  - http://dx.doi.org/10.1007/s10637-015-0265-z
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357462700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/34337
VL  - 33
ER  -
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