Imperial College London

DrNejcHaberman

Faculty of MedicineDepartment of Brain Sciences

Imperial College Research Fellow
 
 
 
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Contact

 

n.haberman

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

The Three Prime Untranslated region (3’UTR) is the non-coding region of an mRNA downstream of the termination codon. The 3’UTR region has evolved a crucial role in complex organisms and is critical in determining mRNA fate, including its stability, localisation, translation and degradation. This is mediated by active interactions with RNA-binding proteins (RBPs) and non-coding RNAs (ncRNAs). Parts of 3’UTRs, also known as 3’UTR-associated RNAs (uaRNAs), are expressed in a cell-specific manner that can also be expressed differently from their normally associated mRNA. Diversity and expression specificity of 3′UTRs is most diverse in brain tissues, where many neural mRNAs excise the longest 3’UTRs and therefore their regulation is likely to be most complex and seems to rely more heavily on uaRNAs than other tissues. More importantly, the stable 3'UTR RNA fragments can also down-regulate their own protein levels in neurons and their accumulation can also work as a hallmark of brain aging, reflecting regional differences in metabolism and oxidative stress. I am interested in understanding the functional significance of uaRNAs in aging brains, and their association to neurodegenerative diseases.

Publications

Journals

Paterson HAB, Yu S, Artigas N, et al., 2022, Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice, Nature Metabolism, Vol:4, ISSN:2522-5812, Pages:1812-1829

Jobbins AM, Haberman N, Artigas N, et al., 2022, Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:3379-3393

Briese M, Haberman N, Sibley CR, et al., 2021, A systems view of spliceosomal assembly and branchpoints with iCLIP (vol 26, pg 930, 2019), Nature Structural & Molecular Biology, Vol:28, ISSN:1545-9993, Pages:455-455

Briese M, Haberman N, Sibley CR, et al., 2020, A systems view of spliceosomal assembly and branchpoints with iCLIP (vol 56, pg 931, 2019), Nature Structural & Molecular Biology, Vol:27, ISSN:1545-9993, Pages:768-768

Lopez-Noriega L, Callingham R, Martinez-Sánchez A, et al., 2020, Roles for the long non-coding RNA<i>Pax6os1</i>/<i>PAX6-AS1</i>in pancreatic beta cell identity and function

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