Imperial College London

Nadey Hakim

Central FacultyOffice of the President

President's Envoy
 
 
 
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Contact

 

+44 (0)7850 503 297n.hakim Website CV

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

68 results found

O'Brien B, Mastoridis S, Sabharwal A, Hakim N, Taube D, Papalois Vet al., 2012, Expanding the Donor Pool: Living Donor Nephrectomy in the Elderly and the Overweight, TRANSPLANTATION, Vol: 93, Pages: 1158-1165, ISSN: 0041-1337

Journal article

Chan K, Taube D, Roufosse C, Cook T, Brookes P, Goodall D, Galliford J, Cairns T, Dorling A, Duncan N, Hakim N, Palmer A, Papalois V, Warrens AN, Willicombe M, McLean AGet al., 2011, Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trial, Transplantation, Vol: 92, Pages: 774-780

BACKGROUND: Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combined with tacrolimus monotherapy maintenance provided equivalent outcomes to the more commonly used combination of interleukin-2 receptor monoclonal antibody induction with tacrolimus and mycophenolate mofetil combination maintenance, both regimens using steroid withdrawal after 7 days. METHODS: One hundred twenty-three live or deceased donor renal transplant recipients were randomized 2:1 to receive alemtuzumab/tacrolimus or daclizumab/tacrolimus/mycophenolate. The primary endpoint was survival with a functioning graft at 1 year. RESULTS: Both regimens produced equivalent, excellent outcomes with the primary outcome measure of 97.6% in the alemtuzumab arm and 95.1% in the daclizumab arm at 1 year (95% confidence interval of difference 6.9% to -1.7%) and at 2 years 92.6% and 95.1%. Rejection was less frequent in the alemtuzumab arm with 1- and 2-year rejection-free survival of 91.2% and 89.9% compared with 82.3% and 82.3% in the daclizumab arm. There were no significant differences in terms of the occurrence of opportunistic infections. CONCLUSION: Alemtuzumab induction with tacrolimus maintenance monotherapy and short-course steroid use provides a simple, safe, and effective immunosuppressive regimen for renal transplantation

Journal article

Mastoridis S, O'Brien B, Sabharwal A, Taube D, Hakim N, Papalois Vet al., 2011, EXPANDING THE ENVELOPE: OLDER AGE AND ITS IMPACT ON PERIOPERATIVE AND LONG-TERM OUTCOMES FOLLOWING LIVING-DONOR NEPHRECTOMY, TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 133-133, ISSN: 0934-0874

Journal article

Mastoridis S, O'Brien B, Sabharwal A, Taube D, Hakim N, Papalois Vet al., 2011, RENAL VESSEL MULTIPLICITY AND ITS IMPACT ON PERIOPERATIVE AND LONG-TERM DONOR OUTCOMES FOLLOWING LIVING-DONOR NEPHRECTOMY, TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 295-295, ISSN: 0934-0874

Journal article

O'Brien B, Sabharwal A, Taube D, Hakim N, Papalois V, Hakim Net al., 2011, WEIGHING UP THE EVIDENCE: DOES THE OBESE KIDNEY DONOR POSE TOO HIGH AN OPERATIVE RISK TO TAKE?, TRANSPL INT, Vol: 24, Pages: 24-24, ISSN: 0934-0874

Journal article

Chan K, Goodall D, Galliford J, Charif R, Duncan N, Papalois V, Hakim N, McLean A, Taube Det al., 2011, Does Alemtuzumab Induction Mitigate the Effects of Delayed Graft Function?, American Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 402-402, ISSN: 1600-6135

Conference paper

Chan K, Goodall D, Lawrence C, Galliford J, Charif R, Duncan N, Papalois V, Hakim N, McLean A, Taube Det al., 2011, Risk Factors for Malignancy Post Renal Transplantation in Patients Receiving Tacrolimus., American Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 511-512, ISSN: 1600-6135

Conference paper

Chan K, Galliford J, Goodall D, Duncan N, Papalois V, Hakim N, Taube D, McLean Aet al., 2011, 3 Year Results of a Randomised Controlled, Steroid Sparing Trial of Campath and Tacrolimus Compared with Daclizumab, Tacrolimus and Mycophenolate Mofetil in Renal Transplantation, American Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 146-146, ISSN: 1600-6135

Conference paper

Crane J, Hakim N, 2011, The Use of an Implantable Doppler Flow Probe in Kidney Transplantation: First Report in the Literature, EXPERIMENTAL AND CLINICAL TRANSPLANTATION, Vol: 9, Pages: 118-120, ISSN: 1304-0855

Journal article

Aboutaleb E, Leen E, Hakim N, 2011, Assessment of Viability of the Pancreas for Transplantation Using Contrast-Enhanced Ultrasound, TRANSPLANTATION PROCEEDINGS, Vol: 43, Pages: 418-421, ISSN: 0041-1345

Journal article

Rajagopal P, Hakim N, 2011, The Use of a Powdered Polysaccharide Hemostat (HemoStase) in Live Donor Nephrectomies Controls Bleeding and Reduces Postoperative Complications, 12th Congress of the Middle-East-Society-for-Organ-Transplantation (MESOT), Publisher: ELSEVIER SCIENCE INC, Pages: 424-426, ISSN: 0041-1345

Conference paper

Aboutaleb E, Herbert P, Crane J, Hakim Net al., 2010, Mini-Incision Donor Nephrectomy Techniques: A Systematic Review, EXPERIMENTAL AND CLINICAL TRANSPLANTATION, Vol: 8, Pages: 189-195, ISSN: 1304-0855

Journal article

Chan K, Galliford J, Goodall D, Cairns TDH, Charif R, Hakim N, Palmer A, Papalois P, McLean A, Taube Det al., 2010, 5 Year of Minimalist Immunosuppression - Alemtuzumab Induction and Tacrolimus Monotherapy without Steroids or MMF in Renal Transplantation, 10th American Transplant Congress, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 317-317, ISSN: 1600-6135

Conference paper

Aboutaleb E, Leen E, Canelo R, Hakim Net al., 2010, Contrast-Enhanced Ultrasound (CEUS) To Assess Viability of the Pancreas, 10th American Transplant Congress, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 549-549, ISSN: 1600-6135

Conference paper

Lawrence C, Galliford JW, Chan KK, Lee J, Cairns TDH, McLean AG, Papallois V, Hakim N, Taube Det al., 2010, Blood Group Antibody Titres Predict the Feasibility of ABO Incompatible Kidney Transplantation, 10th American Transplant Congress, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 223-223, ISSN: 1600-6135

Conference paper

Hakim N, Aboutaleb E, Syed A, Rajagopal P, Herbert P, Canelo R, Papalois Vet al., 2010, A Fast and Safe Living Donor "Finger-Assisted" Nephrectomy Technique: Results of 359 Cases, TRANSPLANTATION PROCEEDINGS, Vol: 42, Pages: 165-170, ISSN: 0041-1345

Journal article

Hakim N, 2010, Pancreas, islet, and stem cell transplantation for diabetes

Book

Hakim N, Aboutaleb E, Herbert P, Rajagopal P, Syed A, Canelo R, Paplois Vet al., 2009, A FAST AND SAFE LIVING-DONOR "FINGER-ASSISTED" NEPHRECTOMY TECHNIQUE: RESULTS OF 359 CASES, TRANSPLANT INTERNATIONAL, Vol: 22, Pages: 361-361, ISSN: 0934-0874

Journal article

McLean A, Chan K-K, Galliford J, Goodall D, Charif R, Dorling A, Warrens A, Cairns T, Papalois V, Hakim N, Taube Det al., 2009, RANDOMISED CONTROLLED TRIAL OF ALEMTUZUMAB-TACROLIMUS MONOTHERAPY WITH DACLIZUMAB-TACROLIMUS-MYCOPHENOLATE MOFETIL IN RENAL TRANSPLANTATION, TRANSPLANT INTERNATIONAL, Vol: 22, Pages: 91-91, ISSN: 0934-0874

Journal article

Hakim N, Hakim NS, 2009, Artificial Organs, Publisher: Springer Verlag, ISBN: 9781848822818

Other issues covered include pancreatic substitution in case of diabetes, the dialysis machine in kidney failure, the bionic ear in deafness, skin substitutes ...

Book

Elahi M, Asopa S, Pflueger A, Hakim N, Matata Bet al., 2009, Acute kidney injury following cardiac surgery: impact of early versus late haemofiltration on morbidity and mortality, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 35, Pages: 854-863, ISSN: 1010-7940

Journal article

Galliford J, Chan K, Charif R, Cook T, Roufosse C, Kumar N, Loucaidou M, McLean A, Hakim N, Papalois V, Taube Det al., 2009, ABO Incompatible Live Donor Transplantation with Alemtuzumab Induction, Tacrolimus Monotherapy and a Steroid Sparing Protocol., 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 557-557, ISSN: 1600-6135

Conference paper

Chan K, Galliford J, Goodall D, Charif R, Dorling A, Warrens A, Hakim N, Papalois V, Taube D, McLean Aet al., 2009, Randomised Controlled Trial of Alemtuzumab and Tacrolimus Monotherapy with Daclizumab, Tacrolimus and Mycophenolate Mofetil in Renal Transplantation., 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 282-282, ISSN: 1600-6135

Conference paper

Galliford J, Chan K, Willicombe M, Roufosse C, Hakim N, Papalois V, Warrens A, McLean A, Cook T, Taube Det al., 2009, Renal Allograft Rejection after Alemtuzumab Induction and Tacrolimus Monotherapy., 9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 620-621, ISSN: 1600-6135

Conference paper

Galliford J, Charif R, Chan KK, Loucaidou M, Cairns T, Cook HT, Dorling A, Hakim N, McLean A, Papalois V, Malde R, Regan F, Redman M, Warrens AN, Taube Det al., 2008, ABO Incompatible Living Renal Transplantation With a Steroid Sparing Protocol, TRANSPLANTATION, Vol: 86, Pages: 901-906, ISSN: 0041-1337

Journal article

Vlachos K, Mitsis M, El Tayar A, Papalois V, Hakim Net al., 2008, Distal Transplant Pancreatectomy During SPK: Successful Clinical Outcome, INTERNATIONAL SURGERY, Vol: 93, Pages: 189-191, ISSN: 0020-8868

Journal article

Charif R, Chan K, Canelo R, Hakim N, McLean A, Palmer A, Papalois V, Warrens A, Taube Det al., 2008, Campath induction and Tacrolimus monotherapy in simultaneous kidney and pancreas transplantation, 8th American Transplant Congress, Publisher: BLACKWELL PUBLISHING, Pages: 553-553, ISSN: 1600-6135

Conference paper

Borrows R, Loucaidou M, Chusney G, Borrows S, Van Tromp J, Cairns T, Griffith M, Hakim N, McLean A, Palmer A, Papalois V, Taube Det al., 2008, Anaemia and congestive heart failure early post-renal transplantation, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 23, Pages: 1728-1734, ISSN: 0931-0509

Journal article

Vlachos K, Siafakas N, Karameris A, Athanasas G, Theodoropoulos G, Peros G, Papadopoulos J, Hakim Net al., 2008, Apoptosis and adenocarcinoma of the cardia: Expression of p53, Bcl-2, Bcl-X-L, WAF1, and fas proteins and association with characteristics of the tumors, INTERNATIONAL SURGERY, Vol: 93, Pages: 145-154, ISSN: 0020-8868

Journal article

Chan K, Taube D, Galliford J, Charif R, Dorling A, Goodall D, Hakim N, Papalois V, Warrens A, McLean Aet al., 2008, Randomised controlled trial of campath and tacrolimus-monotherapy with daclizumab, tacrolimus and mycophenolate mofetil in renal transplantation; Interim results., 8th American Transplant Congress, Publisher: BLACKWELL PUBLISHING, Pages: 216-216, ISSN: 1600-6135

Conference paper

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