Imperial College London
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DrNeilHill

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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n.hill

 
 
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Location

 

East WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parsons:2021:10.1007/s00421-021-04645-0,
author = {Parsons, IT and Stacey, MJ and Faconti, L and Hill, N and O'Hara, J and Walter, E and Farukh, B and McNally, R and Sharp, H and Patten, A and Grimaldi, R and Gall, N and Chowienczyk, P and Woods, DR},
doi = {10.1007/s00421-021-04645-0},
journal = {European Journal of Applied Physiology},
pages = {1451--1459},
title = {Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners},
url = {http://dx.doi.org/10.1007/s00421-021-04645-0},
volume = {121},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeHeat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to exertion-related incapacity. Mast cell degranulation and muscle mass are possible modifiers, though these hypotheses lack practical evidence. This study had three aims: (1) to characterise pre–post-responses in histamine and mast cell tryptase (MCT), (2) to investigate relationships between whole body muscle mass (WBMM) and changes in blood pressure post-marathon, (3) to identify any differences in incapacitated runners.Methods24 recreational runners were recruited and successfully completed the 2019 Brighton Marathon (COMPLETION). WBMM was measured at baseline. A further eight participants were recruited from incapacitated runners (COLLAPSE). Histamine, MCT, blood pressure, heart rate, body temperature and echocardiographic measures were taken before and after exercise (COMPLETION) and upon incapacitation (COLLAPSE).ResultsIn completion, MCT increased by nearly 50% from baseline (p = 0.0049), whereas histamine and body temperature did not vary (p > 0.946). Systolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressures and systemic vascular resistance (SVR) declined (p < 0.019). WBMM negatively correlated with Δ SBP (r = − 0.43, p = 0.046). For collapse versus completion, there were significant elevations in MCT (1.77 ± 0.25 μg/L vs 1.18 ± 0.43 μg/L, p = 0.001) and body temperature (39.8 ± 1.3 °C vs 36.2 ± 0.8 °C, p < 0.0001) with a non-significant rise in histamine (9.6 ± 17.9 μg/L vs 13.7 ± 33.9 μg/L, p = 0.107) and significantly lower MAP, DBP and SVR (p < 0.033).ConclusionThese data support the hypothesis that mast
AU  - Parsons,IT
AU  - Stacey,MJ
AU  - Faconti,L
AU  - Hill,N
AU  - O'Hara,J
AU  - Walter,E
AU  - Farukh,B
AU  - McNally,R
AU  - Sharp,H
AU  - Patten,A
AU  - Grimaldi,R
AU  - Gall,N
AU  - Chowienczyk,P
AU  - Woods,DR
DO  - 10.1007/s00421-021-04645-0
EP  - 1459
PY  - 2021///
SN  - 1439-6319
SP  - 1451
TI  - Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners
T2  - European Journal of Applied Physiology
UR  - http://dx.doi.org/10.1007/s00421-021-04645-0
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000621238200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007/s00421-021-04645-0
UR  - http://hdl.handle.net/10044/1/105642
VL  - 121
ER  -
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