Imperial College London
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DrNeilHill

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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n.hill

 
 
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Location

 

East WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Matu:2017:10.1007/s00421-017-3683-0,
author = {Matu, J and O'Hara, J and Hill, N and Clarke, S and Boos, C and Newman, C and Holdsworth, D and Ispoglou, T and Duckworth, L and Woods, D and Mellor, A and Deighton, K},
doi = {10.1007/s00421-017-3683-0},
journal = {Eur J Appl Physiol},
pages = {1917--1928},
title = {Changes in appetite, energy intake, body composition, and circulating ghrelin constituents during an incremental trekking ascent to high altitude.},
url = {http://dx.doi.org/10.1007/s00421-017-3683-0},
volume = {117},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE: Circulating acylated ghrelin concentrations are associated with altitude-induced anorexia in laboratory environments, but have never been measured at terrestrial altitude. This study examined time course changes in appetite, energy intake, body composition, and ghrelin constituents during a high-altitude trek. METHODS: Twelve participants [age: 28(4) years, BMI 23.0(2.1) kg m-2] completed a 14-day trek in the Himalayas. Energy intake, appetite perceptions, body composition, and circulating acylated, des-acylated, and total ghrelin concentrations were assessed at baseline (113 m, 12 days prior to departure) and at three fixed research camps during the trek (3619 m, day 7; 4600 m, day 10; 5140 m, day 12). RESULTS: Relative to baseline, energy intake was lower at 3619 m (P = 0.038) and 5140 m (P = 0.016) and tended to be lower at 4600 m (P = 0.056). Appetite perceptions were lower at 5140 m (P = 0.027) compared with baseline. Acylated ghrelin concentrations were lower at 3619 m (P = 0.046) and 4600 m (P = 0.038), and tended to be lower at 5140 m (P = 0.070), compared with baseline. Des-acylated ghrelin concentrations did not significantly change during the trek (P = 0.177). Total ghrelin concentrations decreased from baseline to 4600 m (P = 0.045). Skinfold thickness was lower at all points during the trek compared with baseline (P ≤ 0.001) and calf girth decreased incrementally during the trek (P = 0.010). CONCLUSIONS: Changes in plasma acylated and total ghrelin concentrations may contribute to the suppression of appetite and energy intake at altitude, but differences in the time course of these responses suggest that additional factors are also involved. Interventions are required to maintain appetite and energy balance during trekking at terrestrial altitudes.
AU  - Matu,J
AU  - O'Hara,J
AU  - Hill,N
AU  - Clarke,S
AU  - Boos,C
AU  - Newman,C
AU  - Holdsworth,D
AU  - Ispoglou,T
AU  - Duckworth,L
AU  - Woods,D
AU  - Mellor,A
AU  - Deighton,K
DO  - 10.1007/s00421-017-3683-0
EP  - 1928
PY  - 2017///
SP  - 1917
TI  - Changes in appetite, energy intake, body composition, and circulating ghrelin constituents during an incremental trekking ascent to high altitude.
T2  - Eur J Appl Physiol
UR  - http://dx.doi.org/10.1007/s00421-017-3683-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28741038
UR  - http://hdl.handle.net/10044/1/57648
VL  - 117
ER  -
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