Imperial College London
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ProfessorNickHopkinson

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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n.hopkinson

 
 
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Location

 

Muscle LabSouth BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Koreny:2021:10.1016/j.arbres.2020.08.001,
author = {Koreny, M and Demeyer, H and Benet, M and Arbillaga-Etxarri, A and Balcells, E and Barberan-Garcia, A and Gimeno-Santos, E and Hopkinson, NS and De, Jong C and Karlsson, N and Louvaris, Z and Polkey, MI and Puhan, MA and Rabinovich, RA and Rodríguez-Roisin, R and Vall-Casas, P and Vogiatzis, I and Troosters, T and Garcia-Aymerich, J and Urban, Training Study Group and PROactive Consortium members and Urban, Training Study Group and Arbillaga-Etxarri, A and Benet, M and Delgado, A and Garcia-Aymerich, J and Gimeno-Santos, E and Torrent-Pallicer, J and Vilaró, J and Barberan-Garcia, A and Balcells, E and Chiaradía, DAR and Marín, A and Ortega, P and Celorrio, N and Teagudo, MM and Montellà, N and Muñoz, L and Toran, P and Simonet, P and Jané, C and Martín-Cantera, C and Borrell, E and Vall-Casas, P and PROactive, Consortium members and Ivanoff, N and Karlsson, N and Corriol-Rohou, S and Jarrod, I and Erzen, D and Brindicci, C and Higenbottam, T and Scuri, M and McBride, P and Kamel, N an},
doi = {10.1016/j.arbres.2020.08.001},
journal = {Archivos de Bronconeumologia},
pages = {214--223},
title = {Patterns of physical activity progression in patients with COPD},
url = {http://dx.doi.org/10.1016/j.arbres.2020.08.001},
volume = {57},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Although mean physical activity in COPD patients declines by 400-500steps/day annually, it is unknown whether the natural progression is the same for all patients. We aimed to identify distinct physical activity progression patterns using a hypothesis-free approach and to assess their determinants. METHODS: We pooled data from two cohorts (usual care arm of Urban Training [NCT01897298] and PROactive initial validation [NCT01388218] studies) measuring physical activity at baseline and 12 months (Dynaport MoveMonitor). We identified clusters (patterns) of physical activity progression (based on levels and changes of steps/day) using k-means, and compared baseline sociodemographic, interpersonal, environmental, clinical and psychological characteristics across patterns. RESULTS: In 291 COPD patients (mean±SD 68±8 years, 81% male, FEV1 59±19%pred) we identified three distinct physical activity progression patterns: Inactive (n=173 [59%], baseline: 4621±1757 steps/day, 12-month change (Δ): -487±1201 steps/day), ActiveImprovers (n=49 [17%], baseline: 7727±3275 steps/day, Δ:+3378±2203 steps/day) and ActiveDecliners (n=69 [24%], baseline: 11 267±3009 steps/day, Δ: -2217±2085 steps/day). After adjustment in a mixed multinomial logistic regression model using Active Decliners as reference pattern, a lower 6-min walking distance (RRR [95% CI] 0.94 [0.90-0.98] per 10m, P=.001) and a higher mMRC dyspnea score (1.71 [1.12-2.60] per 1 point, P=.012) were independently related with being Inactive. No baseline variable was independently associated with being an Active Improver. CONCLUSIONS: The natural progression in physical activity over time in COPD patients is heterogeneous. While Inactive patients relate to worse scores for clinical COPD characteristics, Active Improvers and Decliners cannot be predicted at baseline.
AU  - Koreny,M
AU  - Demeyer,H
AU  - Benet,M
AU  - Arbillaga-Etxarri,A
AU  - Balcells,E
AU  - Barberan-Garcia,A
AU  - Gimeno-Santos,E
AU  - Hopkinson,NS
AU  - De,Jong C
AU  - Karlsson,N
AU  - Louvaris,Z
AU  - Polkey,MI
AU  - Puhan,MA
AU  - Rabinovich,RA
AU  - Rodríguez-Roisin,R
AU  - Vall-Casas,P
AU  - Vogiatzis,I
AU  - Troosters,T
AU  - Garcia-Aymerich,J
AU  - Urban,Training Study Group and PROactive Consortium members
AU  - Urban,Training Study Group
AU  - Arbillaga-Etxarri,A
AU  - Benet,M
AU  - Delgado,A
AU  - Garcia-Aymerich,J
AU  - Gimeno-Santos,E
AU  - Torrent-Pallicer,J
AU  - Vilaró,J
AU  - Barberan-Garcia,A
AU  - Balcells,E
AU  - Chiaradía,DAR
AU  - Marín,A
AU  - Ortega,P
AU  - Celorrio,N
AU  - Teagudo,MM
AU  - Montellà,N
AU  - Muñoz,L
AU  - Toran,P
AU  - Simonet,P
AU  - Jané,C
AU  - Martín-Cantera,C
AU  - Borrell,E
AU  - Vall-Casas,P
AU  - PROactive,Consortium members
AU  - Ivanoff,N
AU  - Karlsson,N
AU  - Corriol-Rohou,S
AU  - Jarrod,I
AU  - Erzen,D
AU  - Brindicci,C
AU  - Higenbottam,T
AU  - Scuri,M
AU  - McBride,P
AU  - Kamel,N
AU  - Tabberer,M
AU  - Troosters,T
AU  - Dobbels,F
AU  - Garcia-Aymerich,J
AU  - de,Boer P
AU  - Kulich,K
AU  - Glendenning,A
AU  - Rudell,K
AU  - Wilson,FJ
AU  - Polkey,MI
AU  - Hopkinson,NS
AU  - Vogiatzis,I
AU  - Nikai,E
AU  - van,der Molen T
AU  - De,Jong C
AU  - Rabinovich,RA
AU  - MacNee,B
AU  - Puhan,MA
AU  - Frei,A
DO  - 10.1016/j.arbres.2020.08.001
EP  - 223
PY  - 2021///
SN  - 0300-2896
SP  - 214
TI  - Patterns of physical activity progression in patients with COPD
T2  - Archivos de Bronconeumologia
UR  - http://dx.doi.org/10.1016/j.arbres.2020.08.001
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33041107
UR  - http://hdl.handle.net/10044/1/83385
VL  - 57
ER  -
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