Publications
191 results found
Marelli-Berg F, Frasca L, Imami N, et al., 1997, Antigen recognition influences transendothelial migration of CD4+ T cells, 5th Annual Congress of the British Society for Immunology, ISSN: 0019-2805
Tarnok A, Lombardi G, Hargreaves R, et al., 1997, Altered calcium signaling in MHC class II restricted antigen presentation by T cells, 28th Annual Meeting of the Deutsche Gesellschaft für Immunologie: Workshop C Antigen Processing and Presentation, Pages: 165-165, ISSN: 0171-2985
Lombardi G, Arnold K, Uren J, et al., 1997, Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 27, Pages: 62-71, ISSN: 0014-2980
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- Citations: 56
Imami N, Brookes P, Lombardi G, et al., 1996, Correlation between the IL-4-producing precursor frequencies and reduced occurrence/risk of graft-versus-host disease, Annual Scientific Meeting of the British Society for Haematology, ISSN: 0007-1048
Sivolapenko GB, Imami N, Larche M, et al., 1996, Enhanced in vivo immunogenicity induced by an antibody to the IL-4 receptor-associated gp200-MR6 molecule, SCANDINAVIAN JOURNAL OF IMMUNOLOGY, Vol: 44, Pages: 135-142, ISSN: 0300-9475
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- Citations: 4
Lombardi G, Hargreaves R, Sidhu S, et al., 1996, Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals, JOURNAL OF IMMUNOLOGY, Vol: 156, Pages: 2769-2775, ISSN: 0022-1767
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- Citations: 40
Ritter MA, Larche M, Taylor-Fishwick DA, et al., 1995, Differential effects of monoclonal antibody MR6 on IL-2- and IL-4-producing human T cells and on IL-4 induced function of B cells, The 9th International Congress of Immunology
Imami N, Brookes P, Hakooz B, et al., 1995, A limiting dilution assay to determine the frequencies of IL-4-producing human alloreactive T helper cells, 9th International Congress of Immunology
IMAMI N, LARCHE M, RITTER MA, 1994, INHIBITION OF ALLOREACTIVITY BY MAB MR6 - DIFFERENTIAL-EFFECTS ON IL-2-PRODUCING AND IL-4-PRODUCING HUMAN T-CELLS, INTERNATIONAL IMMUNOLOGY, Vol: 6, Pages: 1575-1584, ISSN: 0953-8178
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- Citations: 20
Imami N, Ladyman HM, Spanopoulou E, et al., 1992, A novel adhesion molecule in the murine thymic microenvironment: functional and biochemical analysis, Developmental Immunology, Vol: 2, Pages: 161-173, ISSN: 1044-6672
The rat monoclonal antibody (mAb) 4F1, raised against mouse thymic stromal cells, recognizes cortical epithelium in tissue sections of mouse thymus; however, in flow cytometry, activated leucocytes (T cells, B cells, and macrophages) and transformed thymocytes are also positive for the 4F1-antigen (4F1-Ag). Western blotting, under both reducing and nonreducing conditions, demonstrates that the molecule to which 4F1 binds is expressed in four forms, 29, 32, 40, and 43 kD, all of which carry N-linked carbohydrate; and that the structure is identical on epithelium and lymphocytes. The 4F1-Ag on cortical epithelium is partially sensitive to PI-PLC treatment, whereas on transformed epithelial and lymphoid cell lines, it was resistant to this enzyme. The molecule, therefore, may exist in both transmembrane and phosphoinositol-linked forms. In functional blocking experiments, mAb 4F1 gave inhibition of both T-cell proliferation in MLR and of cytotoxic T-cell killing of alloantigenic targets; it also blocked adhesion of transformed thymocytes to thymic epithelial cells in vitro. These molecular and functional characteristics suggest that the 4F1-Ag is a novel adhesion molecule that may be involved both in intrathymic T lymphocyte differentiation and in peripheral T-cell function.
Imami N, Ladyman H, Ritter M, 1990, A NOVEL ADHESION MOLECULE ON MOUSE THYMIC EPITHELIUM AND T LYMPHOCYTES, TENTH INTERNATIONAL CONFERENCE ON LYMPHATIC TISSUES AND GERMINAL CENTRES IN IMMUNE REACTIONS, COMPIEGNE, FRANCE, JULY 1-5, 1990.
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