Imperial College London
Alternate

DrNobuakiKudo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3803n.kudo Website

 
 
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Assistant

 

Miss Suzy Liu +44 (0)20 7594 2135

 
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Location

 

1 006Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nabti:2014:10.1083/jcb.201305049,
author = {Nabti, I and Marangos, P and Bormann, J and Kudo, NR and Carroll, J},
doi = {10.1083/jcb.201305049},
journal = {The Journal of Cell Biology},
pages = {891--900},
title = {Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity},
url = {http://dx.doi.org/10.1083/jcb.201305049},
volume = {204},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Female meiosis is driven by the activities of two major kinases, cyclin-dependent kinase 1 (Cdk1) and mitogen-activated protein kinase (MAPK). To date, the role of MAPK in control of meiosis is thought to be restricted to maintaining metaphase II arrest through stabilizing Cdk1 activity. In this paper, we find that MAPK and Cdk1 play compensatory roles to suppress the anaphase-promoting complex/cyclosome (APC/C) activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I. Furthermore, inhibition of MAPK around the onset of APC/C activity at the transition from meiosis I to meiosis II led to accelerated completion of meiosis I and an increase in aneuploidy at metaphase II. These effects appear to be mediated via a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads to increased APC/C activity. These findings demonstrate new roles for MAPK in the regulation of meiosis in mammalian oocytes.
AU  - Nabti,I
AU  - Marangos,P
AU  - Bormann,J
AU  - Kudo,NR
AU  - Carroll,J
DO  - 10.1083/jcb.201305049
EP  - 900
PY  - 2014///
SN  - 0021-9525
SP  - 891
TI  - Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity
T2  - The Journal of Cell Biology
UR  - http://dx.doi.org/10.1083/jcb.201305049
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333190500006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://rupress.org/jcb/article/204/6/891/37820/Dual-mode-regulation-of-the-APC-C-by-CDK1-and-MAPK
UR  - http://hdl.handle.net/10044/1/84205
VL  - 204
ER  -
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