Publications
16 results found
Kumar N, Khakoo SI, 2018, Hepatocellular carcinoma: Prospects for natural killer cell immunotherapy, HLA, Vol: 92, Pages: 3-11, ISSN: 2059-2302
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- Citations: 6
Kumar N, Khamri W, Sadiq F, et al., 2017, A Novel inhibitory NK cell subpopulation is expanded in Cirrhosis, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 353A-353A, ISSN: 0270-9139
Kumar N, Khamri W, Sadiq F, et al., 2017, Circulating Natural Killer cells in Hepatocellular Carcinoma are hypofunctional with an exhausted phenotype, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 355A-355A, ISSN: 0270-9139
Lebosse F, Singanayagam A, Nathwani R, et al., 2017, A NOVEL POPULATION OF IMMUNOSUPPRESSIVE CD8 T CELLS IS EXPANDED IN PATIENTS WITH DECOMPENSATED LIVER DISEASE, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A6-A6, ISSN: 0017-5749
Lebosse F, Kumar N, Pop O, et al., 2017, A novel population of immunosuppressive CD8 T cells is expanded in patients with decompensated liver disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S146-S146, ISSN: 0168-8278
Koumbi L, Pollicino T, Raimondo G, et al., 2016, Hepatitis B viral replication influences the expression of natural killer cell ligands, Annals of Gastroenterology, Vol: 29, Pages: 348-357, ISSN: 1108-7471
Background Hepatitis B virus (HBV) is accounting for over one million deaths annually due to immune-mediated chronic liver damage. Natural killer (NK) cells are abundant in the liver and contribute in HBV persistence. NK cytotoxic effects are controlled by signals from activatingand inhibitory receptors. HBV may circumvent host antiviral immunity via the regulation of NK receptors and their ligands. We investigated the effect of viral replication and HBeAg mutations on NK mediators expression in the livers of chronic HBV (CHB) patients and in cell cultures.Methods HBV monomers bearing hotspot mutations in the basal core promoter and precore region were transfected into HepG2 cells using a plasmid-free assay. Serum viremia and liver HBV RNA were measured in 19 CHB patients. The expression of HBV RNA and of NKG2D ligands, B7H6, DNAX accessory molecule-1, lectin-like transcript 1 (LLT1), LFA-1 and TRAIL was measured in the livers of CHB patients and transfected cells.Results In general, high HBV replication in CHB patients and cell lines upregulated the mRNA of all NK cell ligands and particularly the inhibitory NK cell ligand, LLT1. The exception was the NKG2D ligand, MICA, that was significantly decreased in patients with high serum viremia and intrahepatic HBV RNA levels.Conclusions HBV replication has differential effects on NK cell ligands suggesting a potential escape mechanisms through up-regulation of LLT1 and down-regulation of MICA. A general trend towards upregulating NK cell ligands can be counteracted by decreasing MICA and hence weakening NK surveillance.
Kumar N, Mroz A, Aletrari M, et al., 2014, LLT1 IS UPREGULATED IN HEPATOCELLULAR CARCINOMA AND INHIBITS NK CELL CYTOTOXICITY, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A92-A92, ISSN: 0017-5749
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- Citations: 1
Satkunanathan S, Kumar N, Bajorek M, et al., 2014, Respiratory Syncytial Virus Infection, TLR3 Ligands, and Proinflammatory Cytokines Induce CD161 Ligand LLT1 Expression on the Respiratory Epithelium, JOURNAL OF VIROLOGY, Vol: 88, Pages: 2366-2373, ISSN: 0022-538X
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- Citations: 30
Purbhoo M, Kumar N, Ashraf S, 2012, LLT1 engages CD161 at the immunological synapse between T cells and hepatocytes, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 504-504, ISSN: 0019-2805
Purbhoo MA, Kumar N, Ashraf S, 2012, LLT1 ENGAGES CD161 AT THE IMMUNOLOGICAL SYNAPSE BETWEEN T CELLS AND HEPATOCYTES, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S315-S315, ISSN: 0168-8278
Kumar N, Bower M, Nelson M, 2012, Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 23, Pages: 59-60, ISSN: 0956-4624
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- Citations: 4
Kennedy PTF, Russo E, Kumar N, et al., 2010, The safety and utility of prophylactic pancreatic duct stents in the prevention of post-ERCP pancreatitis: an analysis of practice in a single UK tertiary referral center, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 24, Pages: 1923-1928, ISSN: 0930-2794
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- Citations: 9
Kennedy P, Adjogatse D, Kumar N, et al., 2009, BISPECTRAL INDEX MONITORING DURING CONSCIOUS SEDATION IN ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A152-A152, ISSN: 0017-5749
Kennedy P, Russo EA, Kumar N, et al., 2009, PROPHYLACTIC PANCREATIC DUCT STENTS IN THE PREVENTION OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) PANCREATITIS: AN ANALYSIS OF PRACTICE IN A SINGLE UK TERTIARY REFERRAL CENTRE, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A7-A7, ISSN: 0017-5749
Kennedy P, Russo E, Kumar N, et al., 2008, SAFETY AND UTILITY OF PROPHYLACTIC PANCREATIC DUCT STENTS: A SINGLE CENTER EXPERIENCE, 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 797A-797A, ISSN: 0270-9139
Kennedy P, Russo E, Kumar N, et al., 2008, Safety and utility of prophylactic pancreatic duct stents: a single centre experience, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 23, Pages: A135-A135, ISSN: 0815-9319
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