Imperial College London

PROFESSOR NICHOLAS LONG

Faculty of Natural SciencesDepartment of Chemistry

Sir Edward Frankland BP Chair -Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5781n.long Website CV

 
 
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Location

 

501jMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

294 results found

Cooper SM, Siakalli C, White AJP, Frei A, Miller PW, Long NJet al., 2022, Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(v) dioxo complexes, DALTON TRANSACTIONS, Vol: 51, Pages: 12791-12795, ISSN: 1477-9226

Journal article

Wilkinson LA, Bennett TLR, Grace IM, Hamill J, Wang X, Au-Yong S, Ismael A, Jarvis SP, Hou S, Albrecht T, Cohen LF, Lambert C, Robinson BJ, Long NJet al., 2022, Assembly, structure and thermoelectric properties of 1,1 '-dialkynylferrocene 'hinges', CHEMICAL SCIENCE, ISSN: 2041-6520

Journal article

Frei A, Rigby A, Yue TTC, Firth G, Ma MT, Long NJet al., 2022, To chelate thallium(i) - synthesis and evaluation of Kryptofix-based chelators for Tl-201, DALTON TRANSACTIONS, Vol: 51, Pages: 9039-9048, ISSN: 1477-9226

Journal article

Cooper SM, White AJP, Eykyn TR, Ma MT, Miller PW, Long NJet al., 2022, N-Centered Tripodal Phosphine Re(V) and Tc(V) Oxo Complexes:Revisiting a [3+2] Mixed-Ligand Approach br, INORGANIC CHEMISTRY, Vol: 61, Pages: 8000-8014, ISSN: 0020-1669

Journal article

Li Z, Li B, Wu X, Sheppard SA, Zhang S, Gao D, Long NJ, Zhu Zet al., 2022, Organometallic-functionalized interfaces for highly efficient inverted perovskite solar cells, SCIENCE, Vol: 376, Pages: 416-+, ISSN: 0036-8075

Journal article

Bennett TLR, Alshammari M, Au-Yong S, Almutlg A, Wang X, Wilkinson LA, Albrecht T, Jarvis SP, Cohen LF, Ismael A, Lambert CJ, Robinson BJ, Long NJet al., 2022, Multi-component self-assembled molecular-electronic films: towards new high-performance thermoelectric systems, CHEMICAL SCIENCE, Vol: 13, Pages: 5176-5185, ISSN: 2041-6520

Journal article

Sheppard SA, Bennett TLR, Long NJ, 2022, Development and Characterisation of Highly Conjugated Functionalised Ferrocenylene Macrocycles, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Vol: 2022, ISSN: 1434-1948

Journal article

Braga M, Leow CH, Gil JH, Teh JH, Carroll L, Long NJ, Tang M-X, Aboagye EOet al., 2021, Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach, PLOS ONE, Vol: 16, ISSN: 1932-6203

Journal article

Baker CA, Romain C, Long NJ, 2021, Cation-pi interactions enabling hard/soft Ti/Ag heterobimetallic cooperativity in lactide ring-opening polymerisation, CHEMICAL COMMUNICATIONS, Vol: 57, Pages: 12524-12527, ISSN: 1359-7345

Journal article

Teh JH, Braga M, Allott L, Barnes C, Hernandez-Gil J, Tang M-X, Aboagye EO, Long NJet al., 2021, A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles, CHEMICAL COMMUNICATIONS, Vol: 57, Pages: 11677-11680, ISSN: 1359-7345

Journal article

Walter ERH, Cooper SM, Boyle JJ, Long NJet al., 2021, Enzyme-activated probes in optical imaging: a focus on atherosclerosis, DALTON TRANSACTIONS, Vol: 50, Pages: 14486-14497, ISSN: 1477-9226

Journal article

Osborne BE, Yue TTC, Waters ECT, Baark F, Southworth R, Long NJet al., 2021, Synthesis and ex vivo biological evaluation of gallium-68 labelled NODAGA chelates assessing cardiac uptake and retention, DALTON TRANSACTIONS, Vol: 50, Pages: 14695-14705, ISSN: 1477-9226

Journal article

Wu Y, Chau H, Thor W, Chan KHY, Ma X, Chan W, Long NJ, Wong Ket al., 2021, Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction, Angewandte Chemie, Vol: 133, Pages: 20463-20469, ISSN: 0044-8249

Journal article

Wu Y, Chau H-F, Thor W, Chan KHY, Ma X, Chan W-L, Long NJ, Wong K-Let al., 2021, Solid-Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 60, Pages: 20301-20307, ISSN: 1433-7851

Journal article

Jiang L, Mak H-N, Walter ERH, Wong W-T, Wong K-L, Long NJet al., 2021, A fluorescent probe for the discrimination of oxidation states of palladium, CHEMICAL SCIENCE, Vol: 12, Pages: 9977-9982, ISSN: 2041-6520

Journal article

Chau H-F, Wu Y, Fok W-Y, Thor W, Cho WC-S, Ma P, Lin J, Mak N-K, Bunzli J-CG, Jiang L, Long NJ, Lung HL, Wong K-Let al., 2021, Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1, JACS AU, Vol: 1, Pages: 1034-1043

Journal article

Boltersdorf T, Gavins FNE, Long NJ, 2021, Long-lived lanthanide emission via a pH-sensitive and switchable LRET complex, CHEMICAL SCIENCE, ISSN: 2041-6520

Journal article

Walter E, Ge Y, Mason J, Boyle J, Long Net al., 2021, A coumarin-porphyrin FRET break-apart probe for heme oxygenase-1, Journal of the American Chemical Society, Vol: 143, Pages: 6460-6469, ISSN: 0002-7863

Heme oxygenase-1 (HO-1) is a vital enzyme in humans that primarily regulates free heme concentrations. The overexpression of HO-1 is commonly associated with cardiovascular and neurodegenerative diseases including atherosclerosis and ischemic stroke. Currently, there are no known chemical probes to detect HO-1 activity, limiting its potential as an early diagnostic/prognostic marker in these serious diseases. Reported here are the design, synthesis, and photophysical and biological characterization of a coumarin–porphyrin FRET break-apart probe to detect HO-1 activity, Fe–L1. We designed Fe–L1 to “break-apart” upon HO-1-catalyzed porphyrin degradation, perturbing the efficient FRET mechanism from a coumarin donor to a porphyrin acceptor fluorophore. Analysis of HO-1 activity using Escherichia coli lysates overexpressing hHO-1 found that a 6-fold increase in emission intensity at 383 nm was observed following incubation with NADPH. The identities of the degradation products following catabolism were confirmed by MALDI-MS and LC–MS, showing that porphyrin catabolism was regioselective at the α-position. Finally, through the analysis of Fe–L2, we have shown that close structural analogues of heme are required to maintain HO-1 activity. It is anticipated that this work will act as a foundation to design and develop new probes for HO-1 activity in the future, moving toward applications of live fluorescent imaging.

Journal article

Bennett TLR, Wilkinson L, Lok JMA, O'Toole R, Long Net al., 2021, Synthesis, electrochemistry and optical properties of highly conjugated alkynyl-ferrocenes and -biferrocenes, Organometallics, Vol: 40, Pages: 1156-1162, ISSN: 0276-7333

Sonogashira reactions are utilized herein to react iodo-ferrocenes and -biferrocenes with terminal alkyne ligands, functionalized with both pyridine and thioanisole groups. High-yielding reactions generate both monoalkynyl and dialkynyl derivatives, the ratio of which can be altered through changes in the reaction stoichiometry. This methodology allowed us to synthesize a large family of derivatives, comprising four symmetrical derivatives (3xx, where x represents a phenyl-substituted terminal alkyne) and six less-studied asymmetrical derivatives (3xy, where x and y represent two different phenyl-substituted terminal alkynes), as well as a number of their biferrocenyl analogues (6x, 7xx, and 7xy), including the first known examples of asymmetrically disubstituted biferrocenes. We examined the electrochemical behavior of all the systems in solution through the use of cyclic voltammetry and demonstrate that these highly conjugated alkynyl ligands exert delicate redox control over the central ferrocene motif. We also note that these substituents display some control over the mixed-valence character present in biferrocene monocations, with thioanisole substituents imparting almost an order of magnitude higher Kc than their pyridyl analogues, and asymmetric systems displaying rare characteristic properties of mixed-valence isomers. The electronic structure of these systems was further elucidated through a combination of UV/vis spectroscopy and density functional theory calculations. Our methodology provides a facile and adaptable route toward the isolation of a number of novel ferrocene and biferrocene derivatives. From our perspective, the asymmetric nature of these systems, along with the delicate and predictable redox control that these ligands exert on the central ferrocene unit(s), could lead to applications in molecular electronics, where these properties have previously shown promise in the fabrication of diodes and rectifiers, as well as in the synthesis of donor

Journal article

Wang X, Ismael A, Almutlg A, Alshammari M, Al-Jobory A, Alshehab A, Bennett TLR, Wilkinson LA, Cohen LF, Long NJ, Robinson BJ, Lambert Cet al., 2021, Optimised power harvesting by controlling the pressure applied to molecular junctions, Chemical Science, Vol: 12, Pages: 5230-5235, ISSN: 2041-6520

A major potential advantage of creating thermoelectric devices using self-assembled molecular layers is their mechanical flexibility. Previous reports have discussed the advantage of this flexibility from the perspective of facile skin attachment and the ability to avoid mechanical deformation. In this work, we demonstrate that the thermoelectric properties of such molecular devices can be controlled by taking advantage of their mechanical flexibility. The thermoelectric properties of self-assembled monolayers (SAMs) fabricated from thiol terminated molecules were measured with a modified AFM system, and the conformation of the SAMs was controlled by regulating the loading force between the organic thin film and the probe, which changes the tilt angle at the metal-molecule interface. We tracked the thermopower shift vs. the tilt angle of the SAM and showed that changes in both the electrical conductivity and Seebeck coefficient combine to optimize the power factor at a specific angle. This optimization of thermoelectric performance via applied pressure is confirmed through the use of theoretical calculations and is expected to be a general method for optimising the power factor of SAMs.

Journal article

Farleigh M, Pham TT, Yu Z, Kim J, Sunassee K, Firth G, Forte N, Chudasama V, Baker JR, Long NJ, Rivas C, Ma MTet al., 2021, New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes, BIOCONJUGATE CHEMISTRY, Vol: 32, Pages: 1214-1222, ISSN: 1043-1802

Journal article

Omoruyi U, Page SJ, Apps S, White AJP, Long NJ, Miller PWet al., 2021, Synthesis and characterisation of a range of Fe, Co, Ru and Rh triphos complexes and investigations into the catalytic hydrogenation of levulinic acid, Journal of Organometallic Chemistry, Vol: 935, Pages: 1-12, ISSN: 0022-328X

The coordination chemistry of the N-triphos ligand (NP3Ph, 1b) has been investigated with range of Fe, Co and Rh precursors and found to form either tridentate or bidentate complexes. Reaction of NP3Ph with [Rh(COD)(CH3CN)2]BF4 resulted in the formation of the tridentate complex [Rh(COD)(κ3 NP3Ph)]BF4 (3) in the solid state, however, in solution a bidentate complex predominates in more polar solvents. Reaction of NP3Ph with Fe carbonyl precursors revealed the formation of the bidentate complexes [Fe(CO)3(κ2-NP3Ph)Fe(CO)4] (4) and [Fe(CO)3(κ2-NP3Ph)] (5), while reaction with FeBr2 resulted in the paramagnetic bidentate complex [Fe(Br)2(κ2-NP3Ph)] (6). Reaction of NP3Ph with CoCl2 gave a dimeric Co species [(κ2-NP3Ph)CoCl(κ1,κ2-NP3Ph)CoCl3] (7), while Zn powder reduction of NP3Ph Co halides resulted in the formation of the tridentate complexes of the type: [Co(X)(k3-NP3Ph)]. The related triphos Ru complex, [Ru(CO3)(CO)(κ3-CP3Ph)] (2), has also been isolated and characterised. Preliminary catalytic hydrogenation of levulinic acid (LA) was conducted with 2 and 3. The Ru complex was found to be catalytically active, giving high conversions of LA to form gamma valerolactone (GVL) and 1,4-pentandiol (1,4-PDO), while 3 was found to be catalytically inactive. In situ catalytic testing with 1b and Fe(BF4)2.6H2O resulted in low conversions of LA while a combination of 1b and Co(BF4)2.6H2O gave higher conversions 75% yields of GVL.

Journal article

Wang C, Sun W, Zhang J, Zhang J, Guo Q, Zhou X, Fan D, Liu H, Qi M, Gao X, Xu H, Gao Z, Tian M, Zhang H, Wang J, Wei Z, Long NJ, Mao Y, Li Cet al., 2021, An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy, NATURE BIOMEDICAL ENGINEERING, Vol: 5, Pages: 278-289, ISSN: 2157-846X

Journal article

Ismael A, Al-Jobory A, Wang X, Alshehab A, Almutlg A, Alshammari M, Grace I, Bennett TLR, Wilkinson LA, Robinson BJ, Long NJ, Lambert Cet al., 2021, Molecular-scale thermoelectricity: as simple as 'ABC' (vol 2, pg 5329, 2020), NANOSCALE ADVANCES, Vol: 3, Pages: 619-619, ISSN: 2516-0230

Journal article

Blower PJ, Cusnir R, Darwesh A, Long NJ, Ma MT, Osborne BE, Price TW, Pellico J, Reid G, Southworth R, Stasiuk GJ, Terry SYA, de Rosales RTMet al., 2021, Gallium: New developments and applications in radiopharmaceutics, RECENT HIGHLIGHTS I, Editors: Hubbard, VanEldik, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 1-35

Book chapter

Boyle J, Long NJ, Walter ERH, Ge Y, Mason JCet al., 2020, COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME, 2017871.1

The present invention relates to compounds for the detection of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be used in the detection of HO-1 in vivo, ex vivo and in vitro, and can also be used in methods of diagnosis and as research reagents.

Patent

Ismael A, Al-Jobory A, Wang X, Alshehab A, Almutlg A, Alshammari M, Grace I, Benett TLR, Wilkinson LA, Robinson BJ, Long NJ, Lambert Cet al., 2020, Molecular-scale thermoelectricity: as simple as 'ABC', NANOSCALE ADVANCES, Vol: 2, Pages: 5329-5334, ISSN: 2516-0230

Journal article

Morse SV, Boltersdorf T, Chan TG, Gavins FNE, Choi JJ, Long NJet al., 2020, In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia, RSC Chemical Biology, Vol: 1, Pages: 385-389, ISSN: 2633-0679

To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.

Journal article

Seneviratne A, Han Y, Wong E, Walter E, Jiang L, Cave L, Long NJ, Carling D, Mason JC, Haskard DO, Boyle Jet al., 2020, Hematoma resolution in vivo is directed by Activating Transcription Factor 1, Circulation Research, Vol: 127, Pages: 928-944, ISSN: 0009-7330

Rationale: The efficient resolution of tissue hemorrhage is an important homeostatic function. In human macrophages in vitro, heme activates an adenosine monophosphate activated protein kinase / activating transcription factor 1 (AMPK/ATF1) pathway that directs Mhem macrophages through coregulation of heme oxygenase 1 (HMOX1, HO-1) and lipid homeostasis genes.Objective: We asked whether this pathway had an in vivo role in mice.Methods and Results: Perifemoral hematomas were used as a model of hematoma resolution. In mouse bone marrow derived macrophages (mBMM), heme induced HO-1, lipid regulatory genes including LXR, the growth factor IGF1, and the splenic red pulp macrophage gene Spic. This response was lost in mBMM from mice deficient in AMPK (Prkab1-/-) or ATF1 (Atf1-/-). In vivo, femoral hematomas resolved completely between day 8 and day 9 in littermate control mice (n=12), but were still present at day 9 in mice deficient in either AMPK (Prkab1-/-) or ATF1 (Atf1-/-) (n=6 each). Residual hematomas were accompanied by increased macrophage infiltration, inflammatory activation and oxidative stress. We also found that fluorescent lipids and a fluorescent iron-analog were trafficked to lipid-laden and iron-laden macrophages respectively. Moreover erythrocyte iron and lipid abnormally colocalized in the same macrophages in Atf1-/- mice. Therefore, iron-lipid separation was Atf1-dependent.Conclusions: Taken together, these data demonstrate that both AMPK and ATF1 are required for normal hematoma resolution.

Journal article

Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R, Long NJet al., 2020, Targeted molecular iron oxide contrast agents for imaging atherosclerotic plaque, Nanotheranostics, Vol: 4, Pages: 184-194, ISSN: 2206-7418

Overview: Cardiovascular disease remains a leading cause of death worldwide, with vulnerable plaque rupture the underlying cause of many heart attacks and strokes. Much research is focused on identifying an imaging biomarker to differentiate stable and vulnerable plaque. Magnetic Resonance Imaging (MRI) is a non-ionising and non-invasive imaging modality with excellent soft tissue contrast. However, MRI has relatively low sensitivity (micromolar) for contrast agent detection compared to nuclear imaging techniques. There is also an increasing emphasis on developing MRI probes that are not based on gadolinium chelates because of increasing concerns over associated systemic toxicity and deposits1. To address the sensitivity and safety concerns of gadolinium this project focused on the development of a high relaxivity probe based on superparamagnetic iron oxide nanoparticles for the imaging of atherosclerotic plaque with MRI. With development, this may facilitate differentiating stable and vulnerable plaque in vivo.Aim: To develop a range of MRI contrast agents based on superparamagnetic iron oxide nanoparticles (SPIONs), and test them in a murine model of advanced atherosclerosis.Methods: Nanoparticles of four core sizes were synthesised by thermal decomposition and coated with poly(maleicanhydride-alt-1-octadecene) (PMAO), poly(ethyleneimine) (PEI) or alendronate, then characterised for core size, hydrodynamic size, surface potential and relaxivity. On the basis of these results, one candidate was selected for further studies. In vivo studies using 10 nm PMAO-coated SPIONs were performed in ApoE-/- mice fed a western diet and instrumented with a perivascular cuff on the left carotid artery. Control ApoE-/- mice were fed a normal chow diet and were not instrumented. Mice were scanned on a 3T MR scanner (Philips Achieva) with the novel SPION contrast agent, and an elastin-targeted gadolinium agent that was shown previously to enable visualisation of plaque burden. Histo

Journal article

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