Publications
306 results found
Albrecht T, Inkpen MS, Lemmer M, et al., 2015, New insights into single-molecule junctions using a robust, unsupervised approach to data collection and analysis, Journal of the American Chemical Society, ISSN: 1520-5126
Inkpen MS, Lemmer M, Fitzpatrick N, et al., 2015, MATLAB script for data sorting
Supporting information associated with the publication "New insights into single-molecule junctions using a robust, unsupervised approach to data collection and analysis", J. Am. Chem. Soc., 2015, DOI: 10.1021/jacs.5b05693. This MATLAB script is a representative example of that used to objectively sort I(s) traces obtained from 1,8-ODT-coated and blank (uncoated) Au substrates. A short 'Guide to...' document is also included to introduce the user.
Inkpen M, Lemmer M, Fitzpatrick N, et al., 2015, Macro Scheduler code for data collection
Supporting information associated with the publication "New insights into single-molecule junctions using a robust, unsupervised approach to data collection and analysis", J. Am. Chem. Soc., 2015, DOI: 10.1021/jacs.5b05693. This Macro Scheduler (MJT Net Ltd, UK) script is a representative example of that used to automatically measure I(s) traces from 1,8-ODT-coated and blank (uncoated) Au substrates using an Agilent 5100 Scanning Tunnelling Microscope (interfacing with PicoView 1.14, Agilent Technologies). A short 'Guide to...' document is also included to introduce the user, as are additional files (Microsoft Excel spreadsheets and images) required by the script.
Phanopoulos A, Miller PW, Long NJ, 2015, Beyond Triphos - New hinges for a classical chelating ligand, Coordination Chemistry Reviews, Vol: 299, Pages: 39-60, ISSN: 1873-3840
Branched triphosphine ligands have been less widely studied than mono- and bi-dentate analogues. The most studied ligand of this type is TriphosPh (CH3C(CH2PPh2)3). Substitution of the apical Csingle bondCH3 moiety with boron, silicon, tin, nitrogen or phosphorus fragments has generated a new family of ligands, in some cases displaying varying coordination chemistry and reactivity to the parent carbon-based system. This review includes the synthetic strategies implemented to afford these ligands, as well as derivatives by way of varying the phosphine substituents. Although not exhaustive, relevant types of reported complexes featuring these ligands are discussed, as well as their reactivity and catalytic applications. Through critical analysis, common themes and chemical trends across this family of apical heteroatomic, branched triphosphines can be identified, leading to improvements in current chemical applications, as well as new areas that remain underdeveloped.
Phanopoulos A, White AJ, Long NJ, et al., 2015, Catalytic transformation of levulinic acid to 2-methyltetrahydrofuran using ruthenium–N-triphos complexes, ACS Catalysis, Vol: 5, Pages: 2500-2512, ISSN: 2155-5435
A series of pre- or in situ-formed ruthenium complexes were assessed for the stepwise catalytic hydrogenation of levulinic acid (LA) to 2-methyltetrahydrofuran (2-MTHF) via γ-valerolactone (γVL) and 1,4-pentanediol (1,4-PDO). Two different catalytic systems based on the branched triphosphine ligands Triphos (CH3C(CH2PPh2)3) and N-triphos (N(CH2PPh2)3) were investigated. The most active catalyst was the preformed ruthenium species [RuH2(PPh3){N(CH2PPh2)3-κ3P}] (5), which gave near quantitative conversion of LA to 1,4-PDO when no acidic additives were present, and 87% 2-MTHF when used in conjunction with HN(Tf)2. Various acidic additives were assessed to promote the final transformation of 1,4-PDO to 2-MTHF; however, only HN(Tf)2 was found to be effective, and NH4PF6 and para-toluenesulfonic acid (p-TsOH) were found to be detrimental. Mechanistic investigations were carried out to explain the observed catalytic trends and importantly showed that PPh3 dissociation from 5 resulted in its improved catalytic reactivity. The presence of acidic additives removes catalytically necessary hydride ligands and may also compete with the substrate for binding to the catalytic metal center, explaining why only an acid with a noncoordinating conjugate base was effective. Crystals suitable for X-ray diffraction experiments were grown for two complexes: [Ru(NCMe)3{N(CH2PPh2)3-κ3P}] (14) and [Ru2(μ-Cl)3{N(CH2PPh2)3-κ3P}2][BPh4] (16).
Phanopoulos A, Long N, Miller P, 2015, The Synthesis, Characterization and Reactivity of a Series of Ruthenium <i>N</i>-triphos<SUP>Ph</SUP> Complexes, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X
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- Citations: 4
Stasiuk GJ, Minuzzi F, Sae-Heng M, et al., 2015, Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic beta-Cell Mass Imaging, Chemistry-A European Journal, Vol: 21, Pages: 5023-5033, ISSN: 1521-3765
: Despite the contribution of changes in pancreaticb-cell mass to the development of all forms of diabetes mellitus,few robust approaches currently exist to monitor thesechanges prospectively in vivo. Although magnetic-resonanceimaging (MRI) provides a potentially useful technique, targetingMRI-active probes to the b cell has proved challenging.Zinc ions are highly concentrated in the secretory granule,but they are relatively less abundant in the exocrinepancreas and in other tissues. We have therefore developedfunctional dual-modal probes based on transition-metal chelatescapable of binding zinc. The first of these, Gd·1, bindsZnII directly by means of an amidoquinoline moiety (AQA),thus causing a large ratiometric Stokes shift in the fluorescencefrom lem =410 to 500 nm with an increase in relaxivityfrom r1=4.2 up to 4.9 mm1 s1. The probe is efficiently accumulatedinto secretory granules in b-cell-derived lines andisolated islets, but more poorly by non-endocrine cells, andleads to a reduction in T1 in human islets. In vivo murinestudies of Gd·1 have shown accumulation of the probe inthe pancreas with increased signal intensity over 140 minutes.
Edwards PP, Krebs B, Long NJ, et al., 2015, Dedication to Lord Lewis: the new chemistry of the elements, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 373, ISSN: 1364-503X
Edwards P, Krebs B, Raithby P, et al., 2015, The new chemistry of the elements Introduction, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 373, ISSN: 1364-503X
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- Citations: 4
Bakewell C, Fateh-Iravani G, Beh D, et al., 2015, Comparing a series of 8-quinolinolato complexes of aluminium, titanium and zinc as initiators for the ring-opening polymerization of rac-lactide., Dalton Transactions, Vol: 44, ISSN: 1477-9226
The preparation and characterization of a series of 8-hydroxyquinoline ligands and their complexes with Ti(iv), Al(iii) and Zn(ii) centres is presented. The complexes are characterized using NMR spectroscopy, elemental analysis and, in some cases, by single crystal X-ray diffraction experiments. The complexes are compared as initiators for the ring-opening polymerization of racemic-lactide; all the complexes show moderate/good rates and high levels of polymerization control. In the case of the titanium or aluminium complexes, moderate iso-selectivity is observed (Pi = 0.75), whereas in the case of the zinc complexes, moderate hetero-selectivity is observed (Ps = 0.70).
Bakewell C, White AJP, Long NJ, et al., 2015, Scandium and Yttrium Phosphasalen Complexes as Initiators for Ring-Opening Polymerization of Cyclic Esters, Inorganic Chemistry, Vol: 54, Pages: 2204-2212, ISSN: 1520-510X
Gallo J, Long NJ, 2015, NANOPARTICULATE MRI CONTRAST AGENTS, CHEMISTRY OF MOLECULAR IMAGING, Editors: Long, Wong, Publisher: JOHN WILEY & SONS INC, Pages: 199-224, ISBN: 978-1-118-09327-6
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- Citations: 1
Duerrbeck A, Gorelik S, Hobley J, et al., 2015, New solid-state Eu(III)-containing metallo-supramolecular polymers: morphology control and optical wave-guiding properties, JOURNAL OF MATERIALS CHEMISTRY C, Vol: 3, Pages: 8992-9002, ISSN: 2050-7526
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- Citations: 13
Casey D, Wylie D, Gallo J, et al., 2015, A novel, all-optical tool for controllable and non-destructive poration of cells with single-micron resolution, Bio-Optics: Design and Application 2015, Publisher: Optical Society of America
We demonstrate controllable poration within ≈1 µm regions of individual cells, mediated by a near-IR laser interacting with thin-layer amorphous silicon substrates. This technique will allow new experiments in single-cell biology, particularly in neuroscience.
Duerrbeck A, Gorelik S, Hobley J, et al., 2015, Highly emissive, solution-processable and dynamic Eu(III)-containing coordination polymers, CHEMICAL COMMUNICATIONS, Vol: 51, Pages: 8656-8659, ISSN: 1359-7345
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- Citations: 17
Rivas C, Stasiuk GJ, Sae-Heng M, et al., 2015, Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions, DALTON TRANSACTIONS, Vol: 44, Pages: 4976-4985, ISSN: 1477-9226
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- Citations: 19
Long NJ, Wong W-T, 2015, PREFACE, Chemistry of Molecular Imaging, Editors: Long, Wong, Publisher: JOHN WILEY & SONS INC, Pages: IX-U9, ISBN: 978-1-118-09327-6
Neri G, Walsh JJ, Wilson C, et al., 2015, A functionalised nickel cyclam catalyst for CO<sub>2</sub> reduction: electrocatalysis, semiconductor surface immobilisation and light-driven electron transfer, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 17, Pages: 1562-1566, ISSN: 1463-9076
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- Citations: 55
Stasiuk GJ, Holloway PM, Rivas C, et al., 2015, <SUP>99m</SUP>Tc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation, DALTON TRANSACTIONS, Vol: 44, Pages: 4986-4993, ISSN: 1477-9226
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- Citations: 18
Inkpen MS, White AJP, Albrecht T, et al., 2014, Avoiding problem reactions at the ferrocenyl-alkyne motif: a convenient synthesis of model, redox-active complexes for molecular electronics, DALTON TRANSACTIONS, Vol: 43, Pages: 15287-15290, ISSN: 1477-9226
Hurtubise VL, McArdle JM, Naeem S, et al., 2014, Multimetallic Complexes and Functionalized Nanoparticles Based on Unsymmetrical Dithiocarbamate Ligands with Allyl and Propargyl Functionality, INORGANIC CHEMISTRY, Vol: 53, Pages: 11740-11748, ISSN: 0020-1669
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- Citations: 19
Haslop A, Wells L, Gee A, et al., 2014, One-Pot Multi-Tracer Synthesis of Novel <SUP>18</SUP>F-Labeled PET Imaging Agents, MOLECULAR PHARMACEUTICS, Vol: 11, Pages: 3818-3822, ISSN: 1543-8384
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- Citations: 23
Gallo J, Kamaly N, Lavdas I, et al., 2014, CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging, Angewandte Chemie International Edition, Vol: 53, Pages: 9550-9554, ISSN: 1521-3773
MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, thereby leading to a self-assembled superparamagnetic nanocluster network with T2 signal enhancement properties. For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyethylene glycol (PEG) layers tethered to CXCR4-targeted peptide ligands were synthesized and characterized. The IONPs were tested in vitro and T2 signal enhancements of around 160 % were measured when the IONPs were incubated with cells expressing MMP2/9 and CXCR4. Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated the signal-enhancing ability of these ‘smart’ self-assembling nanomaterials.
Williams CK, Bakewell C, Long N, et al., 2014, Stereoblock polylactide: New, highly active, and iso-selective catalysts based on group 3/lanthanide phosphasalen complexes, 248th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Bakewell C, White AJP, Long NJ, et al., 2014, Metal-Size Influence in Iso-Selective Lactide Polymerization, Angewandte Chemie-International Edition, Vol: 53, Pages: 9226-9230, ISSN: 1521-3773
Iso-selective initiators for the ring-opening polymerization (ROP) of rac-lactide are rare outside of Group 13. We describe the first examples of highly iso-selective lutetium initiators. The phosphasalen lutetium ethoxide complex shows excellent iso-selectivity, with a Pi value of 0.81–0.84 at 298 K, excellent rates, and high degrees of polymerization control. Conversely, the corresponding La derivative exhibits moderate heteroselectivity (Ps=0.74, 298 K). Thus, the choice of metal center is shown to be crucial in determining the level and mode of stereocontrol. The relative order of rates for the series of complexes is inversely related to metallic covalent radius: that is, La>Y>Lu.
Wells L, Haslop A, Coello C, et al., 2014, Evaluation of novel phosphonium cations as imaging agents for changes in mitochondrial membrane potential, Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Publisher: SOC NUCLEAR MEDICINE INC, ISSN: 0161-5505
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- Citations: 3
Phanopoulos A, Brown NJ, White AJP, et al., 2014, Synthesis, Characterization, and Reactivity of Ruthenium Hydride Complexes of N-Centered Triphosphine Ligands, INORGANIC CHEMISTRY, Vol: 53, Pages: 3742-3752, ISSN: 0020-1669
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- Citations: 28
Genicio N, Gallo J, Dziasko M, et al., 2014, Biofunctionalized heavy metal free quantum dots (QD) as a tool for tracking transplanted limbal epithelial cells, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Kealey S, White AJP, Gee AD, et al., 2014, Evaluation of [<SUP>12</SUP>C/<SUP>11</SUP>C] Carbon Monoxide Binding to Copper( I) Tris( pyrazolyl) borate Complexes, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Vol: 2014, Pages: 1896-1905, ISSN: 1434-1948
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- Citations: 8
Gallo J, Alam IS, Jin J, et al., 2014, PET imaging with multimodal upconversion nanoparticles, DALTON TRANSACTIONS, Vol: 43, Pages: 5535-5545, ISSN: 1477-9226
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- Citations: 21
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