Publications
306 results found
Ghani SFA, Wright M, Paramo JG, et al., 2014, Three bisphosphonate ligands improve the water solubility of quantum dots, FARADAY DISCUSSIONS, Vol: 175, Pages: 153-169, ISSN: 1359-6640
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- Citations: 5
Gallo J, Alam IS, Lavdas I, et al., 2013, RGD-targeted MnO nanoparticles as T1 contrast agents for cancer imaging – the effect of PEG length in vivo, J. Mater. Chem. B
As magnetic resonance imaging (MRI) contrast agents, T1 Gd3+ chelates are generally the preferred option for radiologists over T2 iron oxide nanoparticles. The main reason for the popularity of T1 agents is the easier interpretation of T1-weighted MR images. However, the chemical versatility of nanoparticulate platforms makes them ideal candidates for the next generation of targeted MRI contrast agents. In this context, we present herein the design and preparation of a nanoparticulate contrast agent based on MnO, which presents T1 contrast enhancement properties as well as nanoparticle formulation. Functionalization of MnO nanoparticles with the extensively studied RGD peptide was used to target tumours over-expressing the αvβ3 integrin. PEG (polyethylene glycol) molecules were used to increase the blood half-life of the nanoparticles in vivo, and the effect of different PEG lengths on the final contrast on MR images was investigated.
Rivas C, Stasiuk GJ, Gallo J, et al., 2013, Lanthanide(III) Complexes of Rhodamine-DO3A Conjugates as Agents for Dual-Modal Imaging, INORGANIC CHEMISTRY, Vol: 52, Pages: 14284-14293, ISSN: 0020-1669
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- Citations: 38
Bakewell C, White AJP, Long NJ, et al., 2013, 8-quinolinolato gallium complexes: iso-selective initiators for rac-lactide polymerization, Inorganic Chemistry, Vol: 52, Pages: 12561-12567, ISSN: 1520-510X
The synthesis and characterization of a series of 8-quinolinolato gallium complexes is presented, and the complexes are analogous to a series of aluminum complexes previously reported. The complexes have been shown to be active initiators for the ring-opening polymerization of rac-lactide. High degrees of polymerization control are demonstrated, as exemplified by the linear evolution of molecular weight as the polymerization progresses, narrow polydispersity indices, and molecular weights corresponding to those predicted on the basis of initiator concentration. Some of the initiators show iso-selective polymerization of rac-lactide, with Pi = 0.70. The polymerization rates have been monitored, and the pseudo first-order rate constants are compared to those of analogous aluminum compounds. The 8-quinolinolato gallium initiators show rates approximately 3 times higher than those of the series of aluminum compounds, while maintaining equivalently high iso-selectivity (Pi = 0.70) and polymerization control.
Inkpen MS, Albrecht T, Long NJ, 2013, Branched Redox-Active Complexes for the Study of Novel Charge Transport Processes, ORGANOMETALLICS, Vol: 32, Pages: 6053-6060, ISSN: 0276-7333
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- Citations: 21
Stasiuk GJ, Minuzzi F, Sae-Heng M, et al., 2013, Dual modal MR/fluorescent zinc sensing probes for in vivo beta cell imaging, 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S211-S211, ISSN: 0012-186X
Haslop A, Wells L, Murphy P, et al., 2013, Novel <SUP>18</SUP>F-labelled phosphonium cations as imaging agents of the mitochondrial membrane potential during apoptosis, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: S143-S143, ISSN: 0362-4803
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- Citations: 1
Haslop A, Gee A, Plisson C, et al., 2013, Fully automated radiosynthesis of [1-(2-[18F]fluoroethyl),1H[1,2,3]triazole 4-ethylene] triphenylphosphonium bromide as a potential positron emission tomography tracer for imaging apoptosis, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: 313-316, ISSN: 0362-4803
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- Citations: 19
Bakewell CM, Thi-Phuong-Anh C, Haaf M, et al., 2013, <i>Bis</i>(quinolinolato)aluminium ethyl and yttrium phosphasalen complexes: New <i>iso</i>-selective initiators for <i>rac</i>-lactide ring-opening polymerisation, 245th National Spring Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Bakewell C, Thi-Phuong-Anh C, Le Goff XF, et al., 2013, Yttrium Phosphasalen Initiators for <i>rac</i>-Lactide Polymerization, ORGANOMETALLICS, Vol: 32, Pages: 1475-1483, ISSN: 0276-7333
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- Citations: 55
Tietz O, Kamaly N, Smith G, et al., 2013, Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents., Am J Nucl Med Mol Imaging, Vol: 3, Pages: 372-383, ISSN: 2160-8407
The G-protein coupled C-X-C chemokine receptor type 4 (CXCR4) is highly overexpressed in a range of cancers and is therefore an excellent biomarker for cancer imaging. To this end targeted iron oxide nanoparticles were developed and utilised for in vitro imaging of MDA-MB-231 breast cancer cells overexpressing the CXCR4 receptor. Nanoparticles comprising an iron oxide core, encapsulated in a stabilising epichlorohydrin crossed-linked dextran polymer, were conjugated to a cyclopentapeptide with affinity to the CXCR4 receptor. The particles were characterized for their size, surface charge and r2 relaxivity at 4.7 T. MR imaging of the CXCR4 receptor with targeted iron oxide nanoparticles revealed an approximately 3-fold increase in T2 signal enhancement of MDA-MB-231 cells compared to non-targeted controls. Prussian blue staining of labeled MDA-MB-231 cells revealed darker and more intense staining of the cellular membrane. This study demonstrates the potential of targeted iron oxide nanoparticles for the imaging of the CXCR4 receptor by magnetic resonance imaging (MRI).
Gallo J, Long NJ, Aboagye EO, 2013, Magnetic nanoparticles as contrast agents in the diagnosis and treatment of cancer, CHEMICAL SOCIETY REVIEWS, Vol: 42, Pages: 7816-7833, ISSN: 0306-0012
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- Citations: 178
Stasiuk GJ, Long NJ, 2013, The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 2732-2746, ISSN: 1359-7345
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- Citations: 160
Inkpen MS, White AJP, Albrecht T, et al., 2013, Rapid Sonogashira cross-coupling of iodoferrocenes and the unexpected cyclo-oligomerization of 4-ethynylphenylthioacetate, Chem. Commun.
Stasiuk GJ, Smith H, Wylezinska-Arridge M, et al., 2013, Gd<SUP>3+</SUP> cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 564-566, ISSN: 1359-7345
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- Citations: 30
Inkpen MS, Du S, Driver M, et al., 2013, Oxidative purification of halogenated ferrocenes, Dalton Transactions, Vol: 42, Pages: 2813-2816
Inkpen MS, Albrecht T, Long NJ, 2013, Branched Redox-Active Complexes for the Study of Novel Charge Transport Processes, Organometallics, Vol: 32, Pages: 6053-6060
Bakewell C, Thi-Phuong-Anh C, Long N, et al., 2012, Yttrium Phosphasalen Initiators for <i>rac</i>-Lactide Polymerization: Excellent Rates and High Iso-Selectivities, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 134, Pages: 20577-20580, ISSN: 0002-7863
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- Citations: 193
Stasiuk GJ, Faulkner S, Long NJ, 2012, Novel imaging chelates for drug discovery, CURRENT OPINION IN PHARMACOLOGY, Vol: 12, Pages: 576-582, ISSN: 1471-4892
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- Citations: 7
Tate CW, Gee AD, Vilar R, et al., 2012, Reversible carbon monoxide binding at copper(I) P-S-X (<i>X</i>=N, O) coordination polymers, JOURNAL OF ORGANOMETALLIC CHEMISTRY, Vol: 715, Pages: 39-42, ISSN: 0022-328X
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- Citations: 1
Child C, Gee A, Long N, et al., 2012, Measuring non-specific binding of novel PET radioligands to determine structure-activity relationships between NSB and their physiochemical properties, 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Publisher: NATURE PUBLISHING GROUP, Pages: S108-S109, ISSN: 0271-678X
Bakewell C, Platel RH, Cary SK, et al., 2012, Bis(8-quinolinolato)aluminum ethyl complexes: Iso-Selective Initiators for <i>rac</i>-Lactide Polymerization, ORGANOMETALLICS, Vol: 31, Pages: 4729-4736, ISSN: 0276-7333
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- Citations: 90
Stasiuk GJ, Long N, Gavins FNE, 2012, Single Photon Emission Computed Tomography Imaging Agents for Formyl Peptide Receptors 1 and 2, Experimental Biology
Gong X, Miller PW, Gee AD, et al., 2012, Gas–Liquid Segmented Flow Microfluidics for Screening Pd-Catalyzed Carbonylation Reactions, Chemistry: A European Journal, Vol: 18, Pages: 2768-2772
Inkpen MS, Long NJ, 2012, Metal sigma-Alkynyl Complexes as Molecular Wires and Devices: A Comparative Study of Electron Density and Delocalisation, Publisher: Royal Society of Chemistry, Pages: 85-129
Tate CW, deMello A, Gee AD, et al., 2012, Hemilabile and reversible carbon monoxide binding properties of iron(II), cobalt(II) and nickel(II) complexes containing a new tridentate P-S-N ligand, DALTON TRANSACTIONS, Vol: 41, Pages: 83-89, ISSN: 1477-9226
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- Citations: 12
Long N, Kealey S, Jennings L, et al., 2011, Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomography, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 54, Pages: S98-S98, ISSN: 0362-4803
Hall JJ, Davies RP, Long NJ, et al., 2011, Oxidative stability of biodiesel in the crankcase environment, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Haslop A, Marzano C, Long N, et al., 2011, Development of <SUP>18</SUP>F-labelled phosphonium cations as PET imaging agents of the mitochondrial function during apoptosis, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 54, Pages: S454-S454, ISSN: 0362-4803
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- Citations: 1
Macey R, Ces O, Gee A, et al., 2011, Predicting and measuring the <i>in vitro</i> non-specific binding of a series of drug analogues, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 54, Pages: S126-S126, ISSN: 0362-4803
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