Imperial College London
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PROFESSOR NICHOLAS LONG

Faculty of Natural Sciences, Department of Chemistry

Sir Edward Frankland BP Chair -Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5781n.long Website CV

 
 
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Location

 

501jMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leow:2019:10.1109/TUFFC.2019.2906434,
author = {Leow, CH and Bush, N and Stanziola, A and Braga, M and Shah, A and Hernández-Gil, J and Long, NJ and Aboagye, E and Bamber, J and Tang, M},
doi = {10.1109/TUFFC.2019.2906434},
journal = {IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control},
pages = {939--948},
title = {3D microvascular imaging using high frame rate ultrasound and ASAP without contrast agents: development and initial in vivo evaluation on non-tumour and tumour models},
url = {http://dx.doi.org/10.1109/TUFFC.2019.2906434},
volume = {66},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Three-dimensional  imaging  is  valuable  to  non-invasively    assess    angiogenesis    given    the    complex    3D architecture  of  vascular  networks.    The  emergence  of  high frame rate (HFR) ultrasound, which can produce thousands of images   per   second,   has   inspired   novel   signal   processing techniques  and  their  applications  in  structural  and  functionalimaging  of  blood  vessels.  Although  highly  sensitive  vascular mapping  has  been  demonstrated  using  ultrafast  Doppler,  the detectability  of  microvasculature  from  the  background  noise may  be  hindered  by  the  low  signal  to  noise  ratio  (SNR) particularly  in  deeper  region  and  without  the  use  of  contrast agents.  We  have  recently  demonstrated  a  coherence  based technique,  acoustic  sub-aperture  imaging  (ASAP),  for  super-contrast    vascular    imaging    and    illustrated    the    contrast improvement using HFR contrast-enhanced ultrasound. In this work, we provide a feasibility study for microvascular imaging using ASAP without contrast agents, and extend its capability from 2D to volumetric vascular mapping. Using an ultrasound research system and a pre-clinical probe, we demonstrated the improved  visibility  of  microvascular  mapping  using  ASAP  in comparison  to  ultrafast  Power  Doppler  (PD)  on  a  mouse kidney, liver and tumour without contrast agent injection. The SNR  of  ASAP  images  improves  in  average  by  10dB  when compared to PD. Besides,  directional  velocity  mappings  were also   demonstrated   by   combining   ASAP   with   the   phase information   extracted   from   lag-1   autocorrelation.      Three-dimensional  vascular  and  velocity  mapping  of  the  mouse kidney,  liver  and  tumour  were  demonstrated  by  stackingthe ASAP  images  acquired  using  2D  ultrasound  imaging  and  a trigger-controlled  linear  translation  stage.    The  3D  results depicted  clear  micro-vasculature  morphologies  and  function
AU  - Leow,CH
AU  - Bush,N
AU  - Stanziola,A
AU  - Braga,M
AU  - Shah,A
AU  - Hernández-Gil,J
AU  - Long,NJ
AU  - Aboagye,E
AU  - Bamber,J
AU  - Tang,M
DO  - 10.1109/TUFFC.2019.2906434
EP  - 948
PY  - 2019///
SN  - 0885-3010
SP  - 939
TI  - 3D microvascular imaging using high frame rate ultrasound and ASAP without contrast agents: development and initial in vivo evaluation on non-tumour and tumour models
T2  - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
UR  - http://dx.doi.org/10.1109/TUFFC.2019.2906434
UR  - http://hdl.handle.net/10044/1/68587
VL  - 66
ER  -
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