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@article{McCluskey:2019:10.2967/jnumed.119.226787,
author = {McCluskey, S and Haslop, A and Coello, C and Gunn, R and Tate, E and Southworth, R and Plisson, C and Long, NJ and Wells, L},
doi = {10.2967/jnumed.119.226787},
journal = {Journal of Nuclear Medicine},
pages = {1750--1756},
title = {Imaging chemotherapy induced acute cardiotoxicity with 18F-labelled lipophilic cations},
url = {http://dx.doi.org/10.2967/jnumed.119.226787},
volume = {60},
year = {2019}
}

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TY  - JOUR
AB  - Many chemotherapy agents are toxic to the heart, such that increasing numbers of cancer survivors are now living with the potentially lethal cardiovascular consequences of their treatment. Earlier and more sensitive detection of chemotherapy-induced cardiotoxicity may allow improved treatment strategies and increase long-term survival. Lipophilic cation positron emission tomography (PET) tracers may be suitable for early detection of cardiotoxicity. This study aims to evaluate an 18F-labelled lipophilic phosphonium cation e.g. 18F-Mitophos, as a cardiac imaging agent, comparing it to leading PET and SPECT lipophilic cationic tracers before further assessing its potential for imaging cardiotoxicity in an acute doxorubicin (DOX) model.
AU  - McCluskey,S
AU  - Haslop,A
AU  - Coello,C
AU  - Gunn,R
AU  - Tate,E
AU  - Southworth,R
AU  - Plisson,C
AU  - Long,NJ
AU  - Wells,L
DO  - 10.2967/jnumed.119.226787
EP  - 1756
PY  - 2019///
SN  - 1535-5667
SP  - 1750
TI  - Imaging chemotherapy induced acute cardiotoxicity with 18F-labelled lipophilic cations
T2  - Journal of Nuclear Medicine
UR  - http://dx.doi.org/10.2967/jnumed.119.226787
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31147403
UR  - http://jnm.snmjournals.org/content/60/12/1750
UR  - http://hdl.handle.net/10044/1/76540
VL  - 60
ER  -

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PROFESSOR NICHOLAS LONG

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