Imperial College London
Dr Nandor Marczin

DrNandorMarczin

Faculty of Medicine, Department of Surgery & Cancer

Senior Clinical Lecturer Honorary consultant
 
 
 
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Contact

 

+44 (0)1895 453 804n.marczin

 
 
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Location

 

Heart Science CentreHarefield HospitalHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@inbook{Marczin:2020:10.1007/978-3-030-28528-9_19,
author = {Marczin, N and Romano, R and Scaramuzzi, M},
booktitle = {Anesthesia in Thoracic Surgery: Changes of Paradigms},
doi = {10.1007/978-3-030-28528-9_19},
pages = {277--287},
title = {Lung transplantation: Justification for a paradigm change},
url = {http://dx.doi.org/10.1007/978-3-030-28528-9_19},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Although lung transplantation (LTx) has moved from experimental surgical options to established therapy with increasing worldwide activity, growing recipient waiting lists and improving outcomes, it remains limited by donor shortages, high perioperative morbidity and mortality and the lowest long-term survival of all solid organ transplants. Unfortunately, development of severe Primary Graft Dysfunction (PGD) remains too prevalent and nonpulmonary complications are nearly ubiquitous with both negatively effecting long term patient survival and quality of life. Such analysis highlights the need for anaesthesia and intensive care to take better ownership of the total morbidity burden and perioperative and consequent long-term mortality. It also calls for constant quality improvement and ongoing critical appraisal of our management goals to understand better and to exploit new opportunities to reduce complications, enhance perioperative patient journey and ultimately to improve both short- and long-term survival of lung transplant recipients. This chapter provides insights into the major paradigm shifts in our anaesthesia mission and regarding some of the principle intraoperative and postoperative management strategies. These are underpinned with exciting new basic research progress regarding the leukocyte theory and cytokine concepts of acute lung injury in the setting of LTx.
AU  - Marczin,N
AU  - Romano,R
AU  - Scaramuzzi,M
DO  - 10.1007/978-3-030-28528-9_19
EP  - 287
PY  - 2020///
SN  - 9783030285272
SP  - 277
TI  - Lung transplantation: Justification for a paradigm change
T1  - Anesthesia in Thoracic Surgery: Changes of Paradigms
UR  - http://dx.doi.org/10.1007/978-3-030-28528-9_19
ER  -
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