Imperial College London
Dr Nandor Marczin

DrNandorMarczin

Faculty of Medicine, Department of Surgery & Cancer

Senior Clinical Lecturer Honorary consultant
 
 
 
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Contact

 

+44 (0)1895 453 804n.marczin

 
 
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Location

 

Heart Science CentreHarefield HospitalHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Paardekooper:2017:10.1038/s41598-017-05930-9,
author = {Paardekooper, LM and van, den Bogaart G and Kox, M and Dingjan, I and Neerincx, AH and Bendix, MB and ter, Beest M and Harren, FJM and Risby, T and Pickkers, P and Marczin, N and Cristescu, SM},
doi = {10.1038/s41598-017-05930-9},
journal = {SCIENTIFIC REPORTS},
title = {Ethylene, an early marker of systemic inflammation in humans},
url = {http://dx.doi.org/10.1038/s41598-017-05930-9},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.
AU  - Paardekooper,LM
AU  - van,den Bogaart G
AU  - Kox,M
AU  - Dingjan,I
AU  - Neerincx,AH
AU  - Bendix,MB
AU  - ter,Beest M
AU  - Harren,FJM
AU  - Risby,T
AU  - Pickkers,P
AU  - Marczin,N
AU  - Cristescu,SM
DO  - 10.1038/s41598-017-05930-9
PY  - 2017///
SN  - 2045-2322
TI  - Ethylene, an early marker of systemic inflammation in humans
T2  - SCIENTIFIC REPORTS
UR  - http://dx.doi.org/10.1038/s41598-017-05930-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000425969300022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62134
VL  - 7
ER  -
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