Imperial College London

ProfessorNicholasMazarakis

Faculty of MedicineDepartment of Brain Sciences

Chair MolBioMedicine and Head of Gene Therapy
 
 
 
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Contact

 

+44 (0)20 7594 7024n.mazarakis Website

 
 
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Assistant

 

Mrs Hadeel Abdeen +44 (0)20 7594 7014

 
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Location

 

E402Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

131 results found

Trepel M, Stoneham CA, Eleftherohorinou H, Mazarakis ND, Pasqualini R, Arap W, Hajitou Aet al., 2009, A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer, MOLECULAR CANCER THERAPEUTICS, Vol: 8, Pages: 2383-2391, ISSN: 1535-7163

Journal article

Jarraya B, Ralph S, Lepetit H, Stratful E, Boulet S, Jan C, Bonvento G, Azzouz M, Miskin JE, Gurruchaga J-M, Vinti M, Fenelon G, Brugiere P, Remy P, Kingsman SM, Hantraye P, Mitrophanous KA, Mazarakis ND, Palfi Set al., 2009, A Phase I/II Trial for Parkinson's Disease Using a Lentiviral Vector (ProSavin®), 12th Annual Meeting of the American Society of Gene Therapy, Publisher: NATURE PUBLISHING GROUP, Pages: S197-S197, ISSN: 1525-0016

Conference paper

Trepel M, Stoneham CA, Mazarakis ND, Pasqualini R, Arap W, Hajitou Aet al., 2009, A Heterotypic Bystander Effect Observed for Tumor Cell Killing after AAVP-Mediated Vascular-Targeted Suicide Gene Transfer, 12th Annual Meeting of the American Society of Gene Therapy, Publisher: NATURE PUBLISHING GROUP, Pages: S108-S108, ISSN: 1525-0016

Conference paper

De Belleroche JS, Mitchell J, Paul P, Chen H-J, Morris A, Hajitou A, Winkler S, Tisato V, Mazarakis Net al., 2009, A Novel Putative Familial ALS Locus on Chromosome 12: D-Amino Acid Oxidase, 61st Annual Meeting of American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A114-A114, ISSN: 0028-3878

Conference paper

Jarraya B, Ralph S, Lepetit H, Boulet S, Jan C, Bonvento G, Azzouz M, Miskin J, Gurruchaga JM, Palfi S, Fenelon G, Brugiere P, Day D, Kingsman S, Hantraye P, Remy P, Mitrophanous K, Mazarakis N, Palfi Set al., 2008, ProSavin: A gene therapy for Parkinson's Disease, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1060-1061, ISSN: 1043-0342

Conference paper

Jarraya B, Ralph S, Bonvento G, Shin M, Jan C, Delzescaux T, Drouot X, Herard A-S, Brouillet E, Azzouz M, Conde F, Miskin J, Kingsman SM, Mazarakis N, Hantraye P, Mitrophanous KA, Palfi Set al., 2007, Lentiviral-mediated dopamine replacement mediates sustained correction of parkinsonian symptoms in an MPTP-lesioned NHP model, 15th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1026-1026, ISSN: 1043-0342

Conference paper

Yip PK, Wong L-F, Pattinson D, Battaglia A, Grist J, Bradbury EJ, Maden M, McMahon SB, Mazarakis NDet al., 2006, Lentiviral vector expressing retinoic acid receptor β2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord, HUMAN MOLECULAR GENETICS, Vol: 15, Pages: 3107-3118, ISSN: 0964-6906

Journal article

So P-L, Yip PK, Bunting S, Wong L-F, Mazarakis ND, Hall S, McMahon S, Maden M, Corcoran JPTet al., 2006, Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth, DEVELOPMENTAL BIOLOGY, Vol: 298, Pages: 167-175, ISSN: 0012-1606

Journal article

Pezet S, Krzyzanowska A, Wong L-F, Grist J, Mazarakis ND, Georgievska B, McMahon SBet al., 2006, Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF, MOLECULAR THERAPY, Vol: 13, Pages: 1101-1109, ISSN: 1525-0016

Journal article

Wong LF, Yip PK, Battaglia A, Grist J, Corcoran J, Maden M, Azzouz M, Kingsman SM, Kingsman AJ, Mazarakis ND, McMahon SBet al., 2006, Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord, NATURE NEUROSCIENCE, Vol: 9, Pages: 243-250, ISSN: 1097-6256

Journal article

Wong LF, Goodhead L, Prat C, Mitrophanous KA, Kingsman SM, Mazarakis NDet al., 2006, Lentivirus-mediated gene transfer to the central nervous system: Therapeutic and research applications, HUMAN GENE THERAPY, Vol: 17, Pages: 1-9, ISSN: 1043-0342

Journal article

Ralph GS, Binley K, Wong LF, Azzouz M, Mazarakis NDet al., 2006, Gene therapy for neurodegenerative and ocular diseases using lentiviral vectors, CLINICAL SCIENCE, Vol: 110, Pages: 37-46, ISSN: 0143-5221

Journal article

Teng QS, Garrity-Moses M, Federici T, Tanase D, Liu JK, Mazarakis ND, Azzouz M, Walmsley LE, Carlton E, Boulis NMet al., 2005, Trophic activity of Rabies G protein-pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro, NEUROBIOLOGY OF DISEASE, Vol: 20, Pages: 694-700, ISSN: 0969-9961

Journal article

Dowd E, Monville C, Torres EM, Wong LF, Azzouz M, Mazarakis ND, Dunnett SBet al., 2005, Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 22, Pages: 2587-2595, ISSN: 0953-816X

Journal article

Ralph GS, Mazarakis ND, Azzouz M, 2005, Therapeutic gene silencing in neurological disorders, using interfering RNA, JOURNAL OF MOLECULAR MEDICINE-JMM, Vol: 83, Pages: 413-419, ISSN: 0946-2716

Journal article

Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DCP, Wong LF, Bilsland LG, Greensmith L, Kingsman SM, Mitrophanous KA, Mazarakis ND, Azzouz Met al., 2005, <sub>S</sub>ilencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model, NATURE MEDICINE, Vol: 11, Pages: 429-433, ISSN: 1078-8956

Journal article

Wong LF, Ralph GS, Walmsley LE, Bienemann AS, Parham S, Kingsman SM, Uney JB, Mazarakis NDet al., 2005, Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus, MOLECULAR THERAPY, Vol: 11, Pages: 89-95, ISSN: 1525-0016

Journal article

Ralph Gareth S, Radcliffe Pippa A, Day Denise M, Carthy Janine M, Kingsman Susan M, Mitrophanous Kyriacos A, Azzouz Mimoun, Mazarakis Nicholas Det al., 2005, Lentiviral-Mediated Silencing of Mutant SOD-1 Using RNAi Causes Long Term Correction of ALS in a Transgenic Mouse Model, Mol Ther, Vol: 11, Pages: S23-S23

Journal article

Kingsman Susan M, Miskin James E, Radcliffe Pippa A, Hacker Caroline V, Chipchase Daniel, Mazarakis Nicholas D, Mitrophanous Kyriacos Aet al., 2005, Safety of In Utero Gene Delivery of Lentiviral Vectors, Mol Ther, Vol: 11, Pages: S153-S153

Journal article

Wong Liang-Fong, Yip Ping K, Battaglia Anna, Grist John, Jones Martin, Maden Malcolm, Kingsman Susan M, Kingsman Alan J, McMahon Stephen B, Mazarakis Nicholas Det al., 2005, Lentiviral Vector Expressing Retinoic Acid Receptor β2 Promotes Regeneration in a Rat Spinal Cord Injury Model Vectors, Mol Ther, Vol: 11, Pages: S251-S251

Journal article

Azzouz M, Le T, Ralph GS, Walmsley L, Monani UR, Lee DCP, Wilkes F, Mitrophanous KA, Kingsman SM, Burghes AHM, Mazarakis NDet al., 2004, Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy, Journal of Clinical Investigation, Vol: 114, Pages: 1726-1731, ISSN: 0021-9738

Journal article

Azzouz M, Le T, Ralph GS, Walmsley L, Monani UR, Lee DCP, Wilkes F, Mitrophanous KA, Kingsman SM, Burghes AHM, Mazarakis NDet al., 2004, Lentivector-mediated <i>SMN</i> replacement in a mouse model of spinal muscular atrophy, JOURNAL OF CLINICAL INVESTIGATION, Vol: 114, Pages: 1726-1731, ISSN: 0021-9738

Journal article

Miller TW, Zhou C, Gines S, MacDonald ME, Mazarakis ND, Bates GP, Huston JS, Messer Aet al., 2004, A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease, NEUROBIOLOGY OF DISEASE, Vol: 19, Pages: 47-56, ISSN: 0969-9961

Journal article

Radcliffe BP, Cosgrave S, Mitrophanous K, Mazarakis N, Uney JBet al., 2004, Reversal of hypothalamic diabetes insipidus using EIAV-based regulatable lentiviral vectors expressing arginine vasopressin, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: JOHN WILEY & SONS LTD, Pages: S35-S36, ISSN: 1099-498X

Conference paper

Azzouz M, Kingsman SM, Mazarakis ND, 2004, Lentiviral vectors for treating and modeling human CNS disorders, JOURNAL OF GENE MEDICINE, Vol: 6, Pages: 951-962, ISSN: 1099-498X

Journal article

Azzouz M, Mazarakis N, 2004, Non-primate EIAV-based lentiviral vectors as gene delivery system for motor neuron diseases, CURRENT GENE THERAPY, Vol: 4, Pages: 277-286, ISSN: 1566-5232

Journal article

Ralph S, Radcliffe PA, Bilsland L, Greensmith L, Mitrophanous KA, Mazarakis ND, Azzouz Met al., 2004, Targeted ablation of mutant SOD1 in ALS models using lentiviral mediated delivery of interfering RNA, 35th Annual Meeting of the Transactions-of-the-American-Society-for-Neurochemistry, Publisher: BLACKWELL PUBLISHING LTD, Pages: 59-59, ISSN: 0022-3042

Conference paper

Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, Kingsman SM, Carmeliet P, Mazarakis NDet al., 2004, VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model, NATURE, Vol: 429, Pages: 413-417, ISSN: 0028-0836

Journal article

Jarraya B, Azzouz M, Miskin J, Ralph SG, Wilkes F, Rohll J, Walmsley LE, Ellard F, Kingsman SM, Mitrophanous KA, Hantraye P, Palphi S, Mazarakis NDet al., 2004, Functional rescue of parkinsonian non-human primates by a dopamine producing multicistronic lentiviral vector, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S407-S407, ISSN: 1525-0016

Conference paper

Teng QS, Garrity-Moses M, Liu JK, Tanase D, Azzouz M, Walmsley L, Mazarakis ND, Boulis NMet al., 2004, EIAV-IGF-I gene transfer to motor neurons enhances axonal length <i>in vitro</i>, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S280-S280, ISSN: 1525-0016

Conference paper

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