Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Chair MolBioMedicine and Head of Gene Therapy



+44 (0)20 7594 7024n.mazarakis Website




Mrs Hadeel Abdeen +44 (0)20 7594 7014




E402Burlington DanesHammersmith Campus





Jesse McClean and Ole Isacsoon, McLean Hospital / Harvard University, 2011

Dr Argyro Sgourou, School of Science and Technology, Hellenic Open University, Patras Greece, 2011

Dr Evanthia Galanis, Mayo Clinic, Rochester Minnesota USA, 2010

Professor Giampietro Schiavo, Cancer Research UK London Research Institute, 2009

Dr Alla Karpova, HHMI/Janelia Farm Research Campus, 2007

Guest Lectures

“Towards gene therapy for a neurodevelopmental disorder: AAV gene replacement therapy in models of cdkl5 disorder” May 17-18, 2019, Hellenic Society of Gene Therapy and Regenerative Medicine, Athens, Greece, 2019

“Viral vectors for gene therapy and modelling of CNS diseases”, 27th Annual meeting of the network of European Transplantation & Restoration (NECTAR), Dublin Ireland, 2017

“Selective vs widespread CNS gene transfer with viral vectors”, BSGCT Annual Conference, Cardiff, 2017

Harnessing viruses for gene therapy and modelling of neurological diseases, The Hellenic Medical Society, Hellenic Centre London, 2016

PGC-1α overexpression by lentiviral vector attenuates amyloid-β load and neuronal loss in an Alzheimer’s disease model, European Society of Gene & Cell Therapy Congress, Florence Italy, 2016

Neuroprotection in an ALS mouse model following peripheral delivery of motor neuron targeted aCAR-IGF-1 Lentiviral vector, ESGCT Congress, Finlandia Hall Helsinki Finland, 2015

AAV Vector Gene Therapy for Parkinson's Disease, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Sweden, 2014

Lentiviral Vectors: Clinical Trials for Neurodegenerative Diseases., Division of Brain Sciences seminar, Imperial College London, 2014

“Gene-based Therapeutics for Neurological Disorders: From Basic Science to Clinical Applications” Fusion Conference Plenary lecture: Lentiviral Vectors: Prospect for Clinical Gene Therapy, Cancun Mexico, 2014

Lentiviral vector based gene therapy in the fight against neurodegenerative diseases, 1st International Multithematic Medical Congress "Bio-Medical Scientific Cyprus",School of Medicine, European University of Cyprus, Nicosia, Cyprus, 2013

Thy1.1, p75NTR or CAR receptor targeting by lentiviral vectors leads to retrograde transport and transduction of spinal motor neurons following peripheral delivery., ESGCT/SETGC collaborative Congress, Madrid, Spain, 2013

Challenges in Translational Medicine TRANSMED Conference"Translational gene therapy approaches for neurodegenerative diseases using lentiviral vectors", Biomedical Research Foundation of the Academy of Athens, Athens Greece, 2013

Gene Therapy Approaches for Parkinson’s Disease,, Mitchell Lewis Seminar Series, Department of Haematology Imperial College Faculty of Medicine, London, 2012

Gene Therapy for Parkinson’s Disease., Neuroméditerranée XII Congress, Institute of Neurology, Paphos Cyprus, 2012

Gene Therapy for Parkinson’s Disease., Academic Neuroscience Guest Lecture, Charing Cross Hospital, 2012

Gene Therapy for Parkinson’s Disease, Cambridge Neurological Society, Addenbrooke’s Hospital Cambridge, 2012

Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/Vesicular stomatitis virus chimeric envelope glycoprotein, European Society of Gene and Cell Therapy & British Society for Gene Therapy Collaborative Congress, Brighton Centre, Brighton, 2011

Viral vectors: research and clinical applications in neurodegenerative diseases and cancer, Inaugural Lecture, Division of Experimental Medicine, Imperial College London, Hammersmith Campus, 2010

Update on current clinical trials: unlocking the potential of Gene Therapy for the treatment of Parkinson's disease., 12th national conference on Parkinson’s, Dexter House, London, 2010

Current Advances in Gene Therapy for Parkinson’s disease., 6th Panhellenic Congress of Pharmacology, Faculty of Medicine University of Crete Heraklion Greece, 2010

Use of AAV and Lentivirus as therapeutic tools for neurodegenerative diseases, European Brain Research InstituteENINET worksop on "Virus based techologies for investigating function & pathology of the nervous system", Rome Italy, 2009

Lentiviral Vectors for Gene Therapy of CNS Diseases, Mayo Clinic, Rochester USA, 2007

Lentiviral Vectors for Gene Delivery to the Parkinsonian Striatum, NINDS Workshop on Gene Delivery to the Nervous System, Washington DC USA, 2007

Gene Therapy of Neurological Disorders, 14th Annual Congress of the European Society of Gene Therapy (ESGT), Athens Greece, 2006

Lentiviral Gene Therapy for CNS disorders, Plenary Lecture: 8th International Conference on Drug and Gene-based Therapeutics, Crete Greece, 2006

Treatment of ALS and SMA Using Lentiviral Mediated Gene Transfer of VEGF and SMN-1, 9th Annual ASGT Meeting, Baltimore USA, 2006

Functional Regeneration of Injured Axons into Adult Spinal Cord by Lentivector® -mediated Delivery of Retinoic Acid Receptor-beta2 to Dorsal Root Ganglion Neurones, 3rd BSGT Annual Meeting, Imperial College London, 2006

Lentiviral vectors in the CNS: Gene Therapy and Research Applications, Sapienza University, Rome Italy, 2006

Research Staff




Research Student Supervision

Eleftheriadou,I, Development of Novel Targeted Lentiviral Vectors for Gene Therapy of Motor Neuron Diseases

Hiraide,R, Investigation of CNS tropism of lentiviral vectors pseudotyped with envelope glycoporotein from a neurovirulant sindbis virus

Islam T,, Characterisation of Retrograde Trafficking Routes Used by Rabies Glycoprotein Pseudotyped Lentiviral Vectors