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@article{Webbe:2020:10.1136/archdischild-2019-317501,
author = {Webbe, J and Duffy, JMN and Afonso, E and Al-Muzaffar, I and Brunton, G and Greenough, A and Hall, NJ and Knight, M and Latour, JM and Lee-Davey, C and Marlow, N and Noakes, L and Nycyk, J and Richard-Löndt, A and Wills-Eve, B and Modi, N and Gale, C},
doi = {10.1136/archdischild-2019-317501},
journal = {Archives of Disease in Childhood: Fetal and Neonatal Edition},
pages = {425--431},
title = {Core outcomes in neonatology: Development of a core outcome set for neonatal research},
url = {http://dx.doi.org/10.1136/archdischild-2019-317501},
volume = {105},
year = {2020}
}

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TY  - JOUR
AB  - BackgroundNeonatal research evaluates many different outcomes using multiple measures. This canprevent synthesis of trial results in meta-analyses and selected outcomes may not berelevant to former patients, parents and health professionals.ObjectiveTo define a core outcome set (COS) for research involving infants receiving neonatal care ina high income setting.DesignOutcomes reported in neonatal trials and qualitative studies were systematically reviewed.Stakeholders were recruited for a three-round international Delphi survey. A consensusmeeting was held to confirm the final COS, based upon the survey results.ParticipantsFour hundred and fourteen former patients, parents, healthcare professionals andresearchers took part in the eDelphi survey; 173 completed all 3 rounds. Sixteenstakeholders participated in the consensus meeting.ResultsThe literature reviews identified 104 outcomes; these were included in round one.Participants proposed ten additional outcomes; 114 outcomes were scored in round two andthree. Round one scores showed different stakeholder groups prioritised contrastingoutcomes. Twelve outcomes were included in the final COS: survival, sepsis, necrotisingenterocolitis, brain injury on imaging, general gross motor ability, general cognitive ability,quality of life, adverse events, visual impairment/blindness, hearing impairment /deafness,retinopathy of prematurity and chronic lung disease/bronchopulmonary dysplasia.6Conclusions and relevanceA COS for clinical trials and other research studies involving infants receiving neonatal carein a high-income setting has been identified. This COS for neonatology will help standardiseoutcome selection in clinical trials and ensure these are relevant to those most affected byneonatal care.
AU  - Webbe,J
AU  - Duffy,JMN
AU  - Afonso,E
AU  - Al-Muzaffar,I
AU  - Brunton,G
AU  - Greenough,A
AU  - Hall,NJ
AU  - Knight,M
AU  - Latour,JM
AU  - Lee-Davey,C
AU  - Marlow,N
AU  - Noakes,L
AU  - Nycyk,J
AU  - Richard-Löndt,A
AU  - Wills-Eve,B
AU  - Modi,N
AU  - Gale,C
DO  - 10.1136/archdischild-2019-317501
EP  - 431
PY  - 2020///
SN  - 1359-2998
SP  - 425
TI  - Core outcomes in neonatology: Development of a core outcome set for neonatal research
T2  - Archives of Disease in Childhood: Fetal and Neonatal Edition
UR  - http://dx.doi.org/10.1136/archdischild-2019-317501
UR  - http://hdl.handle.net/10044/1/74598
VL  - 105
ER  -

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