Imperial College London
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ProfessorNeenaModi

Faculty of Medicine, School of Public Health

Vice-Dean (International Activities) Faculty of Medicine
 
 
 
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Contact

 

+44 (0)20 3315 5102n.modi Website

 
 
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Assistant

 

Miss Angela Rochester +44 (0)20 7594 0937

 
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Location

 

G4.2Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Goss:2020:10.1136/bmjopen-2020-038959,
author = {Goss, KCW and Gale, C and Malone, R and Longford, N and Ratcliffe, K and Modi, N},
doi = {10.1136/bmjopen-2020-038959},
journal = {BMJ Open},
pages = {1--4},
title = {Effect of surfactant dose on outcomes in preterm infants with respiratory distress syndrome: the OPTI-SURF study protocol},
url = {http://dx.doi.org/10.1136/bmjopen-2020-038959},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Respiratory distress syndrome is a condition seen in preterm infants primarily due to surfactant insufficiency. European guidelines recommend the dose and method of surfactant administration. However, in routine practice, clinicians often use a ‘whole vial’ approach to surfactant dosing. The aim of this study is to assess whether in preterm infants of gestational age 36+6 weeks+days or less, a low first dose of surfactant (100–130 mg/kg) compared with a high first dose (170–200 mg/kg) affects survival with no mechanical ventilation on either on postnatal days 3 and 4, and other outcomes.Methods and analysis In this prospective, observational study, we will use the National Neonatal Research Database as the main data source. We will obtain additional information describing the dose and method of surfactant administration through the neonatal EPR system. We will use propensity scores to form matched groups with low first dose and high first dose for comparison.Ethics and dissemination This study was approved by the West Midlands—Black Country Research Ethics Committee (REC reference: 18/WM/0132; IRAS project ID: 237111). The results of the research will be made publicly available through presentations at local, national or international conferences and will be submitted for publication in a peer-reviewed journal.Trial registration number NCT03808402; Pre-results.
AU  - Goss,KCW
AU  - Gale,C
AU  - Malone,R
AU  - Longford,N
AU  - Ratcliffe,K
AU  - Modi,N
DO  - 10.1136/bmjopen-2020-038959
EP  - 4
PY  - 2020///
SN  - 2044-6055
SP  - 1
TI  - Effect of surfactant dose on outcomes in preterm infants with respiratory distress syndrome: the OPTI-SURF study protocol
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2020-038959
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000598721600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/10/12/e038959
UR  - http://hdl.handle.net/10044/1/86584
VL  - 10
ER  -
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