Imperial College London
Portrait Picture

Dr Nicolas Newell

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
//

Contact

 

n.newell09 Website

 
 
//

Location

 

U501aSir Michael Uren HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tavana:2020:10.1016/j.jbiomech.2020.109604,
author = {Tavana, S and Clark, JN and Prior, J and Baxan, N and Masouros, SD and Newell, N and Hansen, U},
doi = {10.1016/j.jbiomech.2020.109604},
journal = {Journal of Biomechanics},
pages = {1--7},
title = {Quantifying deformations and strains in human intervertebral discs using Digital Volume Correlation combined with MRI (DVC-MRI)},
url = {http://dx.doi.org/10.1016/j.jbiomech.2020.109604},
volume = {102},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Physical disruptions to intervertebral discs (IVDs) can cause mechanical changes that lead to degeneration and to low back pain which affects 75% of us in our lifetimes. Quantifying the effects of these changes on internal IVD strains may lead to better preventative strategies and treatments. Digital Volume Correlation (DVC) is a non-invasive technique that divides volumetric images into subsets, and measures strains by tracking the internal patterns within them under load. Applying DVC to MRIs may allow non-invasive strain measurements. However, DVC-MRI for strain measurements in IVDs has not been used previously. The purpose of this study was to quantify the strain and deformation errors associated with DVC-MRI for measurements in human IVDs.Eight human lumbar IVDs were MRI scanned (9.4T) for a ‘zero-strain study’ (multiple unloaded scans to quantify noise within the system), and a loaded study (2mm axial compression). Three DVC methodologies: Fast-Fourier transform (FFT), direct correlation (DC), and a combination of both FFT and DC approaches were compared with subset sizes ranging from 8 to 88 voxels to establish the optimal DVC methodology and settings which were then used in the loaded study.FFT+DC was the optimal method and a subset size of 56 voxels (2520 micrometers) was found to be a good compromise between errors and spatial resolution. Displacement and strain errors did not exceed 28 µm and 3000 microstrain, respectively.These findings demonstrate that DVC-MRI can quantify internal strains within IVDs non-invasively and accurately. The method has unique potential for assessing IVD strains within patients.
AU  - Tavana,S
AU  - Clark,JN
AU  - Prior,J
AU  - Baxan,N
AU  - Masouros,SD
AU  - Newell,N
AU  - Hansen,U
DO  - 10.1016/j.jbiomech.2020.109604
EP  - 7
PY  - 2020///
SN  - 0021-9290
SP  - 1
TI  - Quantifying deformations and strains in human intervertebral discs using Digital Volume Correlation combined with MRI (DVC-MRI)
T2  - Journal of Biomechanics
UR  - http://dx.doi.org/10.1016/j.jbiomech.2020.109604
UR  - https://www.sciencedirect.com/science/article/pii/S0021929020300075?via%3Dihub
UR  - http://hdl.handle.net/10044/1/75865
VL  - 102
ER  -
Download