Imperial College London
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Dr Nuria Oliva-Jorge

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7313n.oliva-jorge Website

 
 
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Location

 

U301ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stejskalova:2019:10.1002/adma.201806380,
author = {Stejskalova, A and Oliva, Jorge N and England, F and Almquist, B},
doi = {10.1002/adma.201806380},
journal = {Advanced Materials},
pages = {1--8},
title = {Biologically inspired, cell-selective release of aptamer-trapped growth factors by traction forces},
url = {http://dx.doi.org/10.1002/adma.201806380},
volume = {31},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Biomaterial scaffolds that are designed to incorporate dynamic, spatiotemporal information have the potential to interface with cells and tissues to direct behavior. Here we describe a bioinspired, programmable nanotechnology-based platform that harnesses cellular traction forces to activate growth factors, eliminating the need for exogenous triggers (e.g. light), spatially diffuse triggers (e.g. enzymes, pH changes) or passive activation (e.g. hydrolysis). We use flexible aptamer technology to create modular, synthetic mimics of the Large Latent Complex that restrains TGF-β1. This flexible nanotechnology-based approach is shown here to work with both platelet-derived growth factor-BB (PDGF-BB) and vascular endothelial growth factor (VEGF-165), integrate with glass coverslips, polyacrylamide gels, and collagen scaffolds, enable activation by various cells (e.g. primary human dermal fibroblasts, HMEC-1 endothelial cells) and unlock fundamentally new capabilities such as selective activation of growth factors by differing cell types (e.g. activation by smooth muscle cells but not fibroblasts) within clinically relevant collagen sponges.
AU  - Stejskalova,A
AU  - Oliva,Jorge N
AU  - England,F
AU  - Almquist,B
DO  - 10.1002/adma.201806380
EP  - 8
PY  - 2019///
SN  - 0935-9648
SP  - 1
TI  - Biologically inspired, cell-selective release of aptamer-trapped growth factors by traction forces
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.201806380
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201806380
UR  - http://hdl.handle.net/10044/1/66675
VL  - 31
ER  -
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