Imperial College London
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Dr Nuria Oliva-Jorge

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7313n.oliva-jorge Website

 
 
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Location

 

U301ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oliva:2020:10.1016/j.addr.2020.07.021,
author = {Oliva, Jorge N and Almquist, B},
doi = {10.1016/j.addr.2020.07.021},
journal = {Advanced Drug Delivery Reviews},
pages = {22--41},
title = {Spatiotemporal delivery of bioactive molecules for wound healing using stimuli-responsive biomaterials},
url = {http://dx.doi.org/10.1016/j.addr.2020.07.021},
volume = {161-162},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Wound repair is a fascinatingly complex process, with overlapping events in both space and time needed to pave a pathway to successful healing. This additional complexity presents challenges when developing methods for the controlled delivery of therapeutics for wound repair and tissue engineering. Unlike more traditional applications, where biomaterial-based depots increase drug solubility and stability in vivo, enhance circulation times, and improve retention in the target tissue, when aiming to modulate wound healing, there is a desire to enable localised, spatiotemporal control of multiple therapeutics. Furthermore, many therapeutics of interest in the context of wound repair are sensitive biologics (e.g. growth factors), which present unique challenges when designing biomaterial-based delivery systems. Here, we review the diverse approaches taken by the biomaterials community for creating stimuli-responsive materials that are beginning to enable spatiotemporal control over the delivery of therapeutics for applications in tissue engineering and regenerative medicine.
AU  - Oliva,Jorge N
AU  - Almquist,B
DO  - 10.1016/j.addr.2020.07.021
EP  - 41
PY  - 2020///
SN  - 0169-409X
SP  - 22
TI  - Spatiotemporal delivery of bioactive molecules for wound healing using stimuli-responsive biomaterials
T2  - Advanced Drug Delivery Reviews
UR  - http://dx.doi.org/10.1016/j.addr.2020.07.021
UR  - https://www.sciencedirect.com/science/article/pii/S0169409X20301058?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80965
VL  - 161-162
ER  -
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