Imperial College London
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Dr Nuria Oliva-Jorge

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7313n.oliva-jorge Website

 
 
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Location

 

U301ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Duran-Mota:2021:10.26434/chemrxiv.14369261.v1,
author = {Duran-Mota, JA and Quintanas, Yani J and Almquist, B and Borrós, S and Oliva, N and Oliva-Jorge, N},
doi = {10.26434/chemrxiv.14369261.v1},
title = {Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts},
url = {http://dx.doi.org/10.26434/chemrxiv.14369261.v1},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:p>Impaired cutaneous healing, leading to chronic wounds, affects between 2 and 6% of the total population in most developed countries and it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings and mechanical debridement are often not effective, causing severe pain, emotional distress and social isolation in patients for years or even decades, ultimately resulting in limb amputation. Alternatively, gene therapy (such as mRNA therapies) emerges as a viable option to promote wound healing through modulation of gene expression. However, protecting the genetic cargo from degradation and efficient transfection into primary cells remain significant challenges in the push to clinical translation. Another limiting aspect of current therapies is the lack of sustained release of drugs to match the therapeutic window. Herein, we have developed an injectable, biodegradable and biocompatible hydrogel-based wound dressing that delivers pBAE nanoparticles in a sustained manner over a range of therapeutic windows. We also demonstrate that pBAE nanoparticles, successfully used in previous <jats:italic>in vivo</jats:italic> studies, protect the mRNA load and efficiently transfect human dermal fibroblasts upon sustained release from the hydrogel wound dressing. This prototype wound dressing technology can enable the development of novel gene therapies for the treatment of chronic wounds.</jats:p>
AU  - Duran-Mota,JA
AU  - Quintanas,Yani J
AU  - Almquist,B
AU  - Borrós,S
AU  - Oliva,N
AU  - Oliva-Jorge,N
DO  - 10.26434/chemrxiv.14369261.v1
PY  - 2021///
TI  - Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts
UR  - http://dx.doi.org/10.26434/chemrxiv.14369261.v1
ER  -
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