Imperial College London
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Dr Nuria Oliva-Jorge

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7313n.oliva-jorge Website

 
 
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Location

 

U301ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Artzi:2011:10.1038/NMAT3095,
author = {Artzi, N and Oliva, N and Puron, C and Shitreet, S and Artzi, S and Ramos, AB and Groothuis, A and Sahagian, G and Edelman, ER},
doi = {10.1038/NMAT3095},
journal = {Nature Materials},
pages = {704--709},
title = {In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging},
url = {http://dx.doi.org/10.1038/NMAT3095},
volume = {10},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of erosion. However, in vivo performance cannot always be predicted by traditional determination of in vitro erosion1,2, and standard methods sacrifice samples or animals3, preventing sequential measures of the same specimen. We harnessed non-invasive fluorescence imaging to sequentially follow in vivo material-mass loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically (collagen). Hydrogel erosion rates in vivo and in vitro correlated, enabling the prediction of in vivo erosion of new material formulations from in vitro data. Collagen in vivo erosion was used to infer physiologic in vitro conditions that mimic erosive in vivo environments. This approach enables rapid in vitro screening of materials, and can be extended to simultaneously determine drug release and material erosion from a drug-eluting scaffold, or cell viability and material fate in tissue-engineering formulations.
AU  - Artzi,N
AU  - Oliva,N
AU  - Puron,C
AU  - Shitreet,S
AU  - Artzi,S
AU  - Ramos,AB
AU  - Groothuis,A
AU  - Sahagian,G
AU  - Edelman,ER
DO  - 10.1038/NMAT3095
EP  - 709
PY  - 2011///
SN  - 1476-1122
SP  - 704
TI  - In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging
T2  - Nature Materials
UR  - http://dx.doi.org/10.1038/NMAT3095
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000294156800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65011
VL  - 10
ER  -
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