Imperial College London
Dr Nazima Pathan

DrNazimaPathan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

n.pathan

 
 
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Location

 

PICURoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pathan:2008,
author = {Pathan, N and Ridout, D and Smith, E and Goldman, A},
journal = {Intensive Care Med.},
pages = {2256--2263},
title = {Predictors of outcome for children requiring respiratory extra-corporeal life support: implications for inclusion and exclusion criteria},
volume = {12},
year = {2008}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AbstractOBJECTIVES:A range of children receive extra-corporeal life support (ECLS) for respiratory failure, but there is little published data on this group. Our aims were: (1) to analyse predictors of outcome and (2) comment on inclusion and exclusion criteria.DESIGN:Retrospective review.SETTING:Tertiary ECLS centre.PATIENTS:A total of 124 children categorised as 'paediatric respiratory ECLS' from July 1992 to December 2005.RESULTS:Fifty-three percent of children had one or more co-morbid conditions; the median age was 10.1 (IQR 3-34) months; the median ECLS duration was 9 (IQR 5-17) days; survival to discharge was 62% and at 1 year was 59%. Although survival varied according to primary reason for ECLS (range 36-100%), after adjustment for this, the presence of a co-morbid condition was unrelated to mortality (OR = 1.49, 95% CI 0.65, 3.42, P = 0.34) Predictors of mortality were increased pre-ECLS oxygenation index (OR = 1.09, 95% CI 1.00, 1.18, P = 0.05) and shock (OR 2.53, 95% CI 1.21, 5.28, P = 0.01). The relationship between mortality and end organ dysfunction (OR 2.12, 95% CI 0.89, 5.02, P = 0.09) and greater number of pre-ECLS ventilator days (OR 1.10, 95% CI 0.99, 1.22, P = 0.08) was less conclusive.CONCLUSIONS:Pre-existing co-morbid conditions may predispose children to develop severe respiratory failure but with careful case selection, do not appear to reduce the chance of survival. Severity of pulmonary dysfunction determined by OI and shock were key predictors of outcome and should remain important determinants of referral for ECLS.
AU  - Pathan,N
AU  - Ridout,D
AU  - Smith,E
AU  - Goldman,A
EP  - 2263
PY  - 2008///
SP  - 2256
TI  - Predictors of outcome for children requiring respiratory extra-corporeal life support: implications for inclusion and exclusion criteria
T2  - Intensive Care Med.
VL  - 12
ER  -
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